{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T10:02:50Z","timestamp":1779962570957,"version":"3.53.1"},"reference-count":12,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T00:00:00Z","timestamp":1778544000000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100012832","name":"Okinaka Memorial Institute for Medical Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012832","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Thoracic SMARCA4\u2010deficient undifferentiated tumor (UT) is a malignant neoplasm characterized by undifferentiated and\/or rhabdoid morphology. This report describes a case of SMARCA4\u2010deficient UT that was incidentally followed by computed tomography. The patient was a man in his 70\u2009s who was undergoing regular chest computed tomography for postoperative surveillance of renal cell carcinoma. Twenty months before diagnosis of SMARCA4\u2010deficient UT, a pulmonary cyst was noted adjacent to the chest wall and increased in size over time. A right upper lobectomy with partial pleurectomy was performed for diagnostic and therapeutic purposes. Macroscopically, we identified a 30\u2010mm mass located predominantly in the chest wall. Histological examination revealed a proliferation of atypical polygonal cells or partly spindle\u2010shaped with prominent nucleoli and irregular nuclear membranes in a nested pattern within the chest wall and lung tissue and partially within striated muscle tissue. Immunohistochemically, the tumor cells showed loss of expression of BRG1\/SMARCA4 and BRM\/SMARCA2. The extrapulmonary component was positive for CD34 and had a Ki\u201067 index that was higher than that in the intrapulmonary component. The radiological, pathological, and molecular findings led to a diagnosis of SMARCA4\u2010deficient UT of intrapulmonary origin.<\/jats:p>","DOI":"10.1111\/pin.70130","type":"journal-article","created":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T05:36:07Z","timestamp":1778650567000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Case of Incidentally Followed Thoracic SMARCA4\u2010Deficient Undifferentiated Tumor: Insights Into the Tumor Origin"],"prefix":"10.1111","volume":"76","author":[{"given":"Hironori","family":"Uruga","sequence":"first","affiliation":[{"name":"Department of Pathology Toranomon Hospital Tokyo Japan"},{"name":"Okinaka Memorial Institute for Medical Research Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Nakahama","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Respiratory Center Toranomon Hospital Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Hirakawa","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Radiology Toranomon Hospital Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsunori","family":"Oikado","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Radiology Toranomon Hospital Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takayuki","family":"Tsujimoto","sequence":"additional","affiliation":[{"name":"Department of Pathology Toranomon Hospital Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Mitsumura","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Respiratory Center Toranomon Hospital Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meiyo","family":"Tamaoka","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Respiratory Center Toranomon Hospital Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sakashi","family":"Fujimori","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Respiratory Center Toranomon Hospital Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Fujii","sequence":"additional","affiliation":[{"name":"Department of Pathology Toranomon Hospital Tokyo Japan"},{"name":"Keio Clinic for Diagnostic Digital Pathology Keio University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutaka","family":"Takazawa","sequence":"additional","affiliation":[{"name":"Department of Pathology Toranomon Hospital Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,12]]},"reference":[{"key":"e_1_2_11_2_1","unstructured":"Board WCoTE WHO Classification of Thoracic Tumours 5th ed. 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