{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T18:47:03Z","timestamp":1782499623649,"version":"3.54.5"},"reference-count":29,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T00:00:00Z","timestamp":1781568000000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["24K18395"],"award-info":[{"award-number":["24K18395"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Factors underlying differential colonization by human intestinal spirochetosis (HIS) of various colorectal neoplastic lesions remain unclear. We compared HIS positivity and colonization patterns between sessile serrated lesions (SSLs) and tubular adenomas (TAs) and examined the relationship between spirochetal distribution and epithelial differentiation. HIS positivity was significantly higher in SSLs than TAs at both lesion (26\/590 [4.4%] vs. 3\/536 [0.6%],\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001) and case (16\/421 [3.8%] vs. 1\/171 [0.6%],\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.03) levels. Because the SSL and TA main cohorts covered different periods, nine HIS\u2010positive SSL cases harboring TAs diagnosed outside the TA cohort period were separately analyzed for within\u2010case comparison, confirming significantly higher HIS positivity in SSLs than TAs (11\/12 [91.7%] vs. 6\/23 [26.1%],\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.003). Among HIS\u2010positive lesions, both SSLs and TAs showed reduced colonization at lesion sites compared to surrounding mucosa, with greater reduction in TAs. GS\u2010II staining demonstrated reduced terminal \u03b2GlcNAc on HIS bacterial bodies at SSL lesion sites. HIS preferentially colonized absorptive epithelium, although less evidently in TAs with limited absorptive differentiation. All cases harbored only\n                    <jats:italic>Brachyspira aalborgi<\/jats:italic>\n                    . These results indicate that HIS exhibits universal affinity for absorptive epithelium and that higher HIS positivity in SSLs reflects their greater abundance of absorptive epithelium.\n                  <\/jats:p>","DOI":"10.1111\/pin.70137","type":"journal-article","created":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T17:58:21Z","timestamp":1781632701000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Human Intestinal Spirochetosis Shows Higher Positivity in Sessile Serrated Lesions Than in Tubular Adenomas With Preferential Colonization of Absorptive Epithelium"],"prefix":"10.1111","volume":"76","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9045-0835","authenticated-orcid":false,"given":"Hisanori","family":"Matoba","sequence":"first","affiliation":[{"name":"Department of Molecular Pathology Shinshu University School of Medicine Matsumoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2135-2219","authenticated-orcid":false,"given":"Mai","family":"Iwaya","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Shinshu University Hospital Matsumoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8735-5274","authenticated-orcid":false,"given":"Chifumi","family":"Fujii","sequence":"additional","affiliation":[{"name":"Department of Molecular Pathology Shinshu University School of Medicine Matsumoto Japan"},{"name":"Shinshu University School of Medicine Matsumoto Japan"},{"name":"Department of Biotechnology, Institute for Biomedical Sciences, Research Cluster for Social Implementation Shinshu University Matsumoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masatomo","family":"Kawakubo","sequence":"additional","affiliation":[{"name":"Department of Molecular Pathology Shinshu University School of Medicine Matsumoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriyasu","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology North Alps Medical Center Azumi Hospital Ikeda\u2010machi, Kitaazumi\u2010gun Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haruka","family":"Kuribayashi","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology North Alps Medical Center Azumi Hospital Ikeda\u2010machi, Kitaazumi\u2010gun Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6773-2802","authenticated-orcid":false,"given":"Jun","family":"Nakayama","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology North Alps Medical Center Azumi Hospital Ikeda\u2010machi, Kitaazumi\u2010gun 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