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Aberrant glycosylation is a hallmark of prostate cancer and plays a functional role in disease progression. The sialyl\u2010Tn antigen (sTn) has been widely studied in cancer, yet its involvement in prostate cancer remains relatively unexplored. Here, we utilise a novel anti\u2010sTn antibody (L2A5) to comprehensively monitor sTn expression levels in clinical prostate cancer tissues encompassing normal, benign, primary, metastatic castration\u2010resistant prostate cancer (CRPC), and in patient\u2010derived xenograft (PDX) tissues. We show that while sTn is detected at low or negligible levels in normal prostate tissues, it is expressed in 44% of prostate tumours, and prostate cancer patients with high sTn levels have significantly poorer survival times. Analysis of metastatic therapy\u2010resistant prostate\u2010derived tumours growing in the liver and bone shows sTn is expressed in 37.5% of cases. Furthermore, sTn is expressed in nearly half of the PDX models tested and was found to be broadly androgen\u2010regulated. These findings identify sTn as a potential prognostic biomarker and therapeutic target in prostate cancer and lay the groundwork for the development of sTn\u2010targeted precision therapies for advanced disease.<\/jats:p>","DOI":"10.1111\/pin.70140","type":"journal-article","created":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T03:52:06Z","timestamp":1782186726000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Comprehensive Profiling Reveals Sialyl\u2010Tn Upregulation and Prognostic Value in Prostate Cancer"],"prefix":"10.1111","volume":"76","author":[{"given":"Kirsty","family":"Hodgson","sequence":"first","affiliation":[{"name":"Newcastle University Centre for Cancer Newcastle University Institute of Biosciences  Newcastle UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Libby","family":"Blencoe","sequence":"additional","affiliation":[{"name":"Newcastle University Centre for Cancer Newcastle University Institute of Biosciences  Newcastle UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin","family":"Smith","sequence":"additional","affiliation":[{"name":"Newcastle University Centre for Cancer Newcastle University Institute of Biosciences  Newcastle UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aswini","family":"Sasikumar","sequence":"additional","affiliation":[{"name":"Newcastle University Centre for Cancer Newcastle University Institute of Biosciences  Newcastle UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziqian","family":"Peng","sequence":"additional","affiliation":[{"name":"Newcastle University Centre for Cancer Newcastle University Institute of Biosciences  Newcastle UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margarita","family":"Orozco\u2010Moreno","sequence":"additional","affiliation":[{"name":"Newcastle University Centre for Cancer Newcastle University Institute of Biosciences  Newcastle UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Beatson","sequence":"additional","affiliation":[{"name":"Comprehensive Cancer Centre King's College London  London"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula A.","family":"Videira","sequence":"additional","affiliation":[{"name":"UCIBIO \u2013 Applied Molecular Biosciences Unit, Department of Life Sciences, NOVA School of Science and Technology | FCT NOVA Universidade NOVA de Lisboa  Caparica Portugal"},{"name":"Associate Laboratory i4HB \u2010 Institute for Health and Bioeconomy, NOVA School of Science and Technology | FCT NOVA Universidade NOVA de Lisboa  Caparica Portugal"},{"name":"CDG &amp; Allies \u2013 Professionals and Patient Associations International Network (CDG &amp; Allies \u2013 PPAIN)  Caparica Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Munkley","sequence":"additional","affiliation":[{"name":"Newcastle University Centre for Cancer Newcastle University Institute of Biosciences  Newcastle UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,22]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/aps.2014.18"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2017.06.002"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1903835"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1503747"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-med-051517-011947"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2013.11.002"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2023.13749"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.8155"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrurol.2016.65"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molonc.2013.03.001"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2010.03667.x"},{"issue":"1","key":"e_1_2_10_14_1","first-page":"197","article-title":"Expression of Tn, Sialosyl\u2010Tn, and T Antigens in Human Colon Cancer","volume":"49","author":"Itzkowitz S. 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