{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T10:05:21Z","timestamp":1785405921634,"version":"3.56.0"},"reference-count":8,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,7,5]],"date-time":"2026-07-05T00:00:00Z","timestamp":1783209600000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>The coexistence of extramammary Paget disease and clinically apparent herpes simplex virus (HSV) infection is extremely uncommon, with only two cases previously described in detail. Herein, we present the case of an elderly woman with an extensive vulvar lesion showing concurrent extramammary Paget disease and HSV infection. Triple immunohistochemical staining for cytokeratin 7, cytokeratin 10, and HSV antigen was performed to re\u2010evaluate the hypothesis that HSV\u2010mediated fusion between Paget cells and keratinocytes contributes to multinucleated giant cell formation. HSV antigen was detected in both Paget cells and keratinocytes. HSV\u2010positive multinucleated giant cells displayed a cytoplasmic staining pattern similar to that of keratinocytes, whereas no Paget cell\u2013like cytoplasmic staining pattern was observed. These findings indicate that HSV can directly infect Paget cells and that the multinucleated giant cells in this case were of keratinocytic origin. No definitive evidence of cell fusion\u2014either among Paget cells or between Paget cells and keratinocytes\u2014was observed in the examined sections. However, the possibility of rare fusion events in unexamined tissue cannot be entirely excluded.<\/jats:p>","DOI":"10.1111\/pin.70146","type":"journal-article","created":{"date-parts":[[2026,7,5]],"date-time":"2026-07-05T16:41:22Z","timestamp":1783269682000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Rare Case of Extramammary Paget Disease With Concurrent Herpes Simplex Virus Infection: Three\u2010Color Immunohistochemical Analysis for Re\u2010Evaluating Previous Hypotheses"],"prefix":"10.1111","volume":"76","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-5671-8624","authenticated-orcid":false,"given":"Yoshikazu","family":"Senda","sequence":"first","affiliation":[{"name":"Department of Diagnostic Pathology Itami City Hospital Hyogo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hayato","family":"Kimura","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology Itami City Hospital Hyogo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2778-3642","authenticated-orcid":false,"given":"Shoichiro","family":"Minami","sequence":"additional","affiliation":[{"name":"Department of Dermatology Itami City Hospital Hyogo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-7636-5833","authenticated-orcid":false,"given":"Masaharu","family":"Kohara","sequence":"additional","affiliation":[{"name":"Department of Pathology Osaka University Graduate School of Medicine Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8490-3650","authenticated-orcid":false,"given":"Eiichi","family":"Morii","sequence":"additional","affiliation":[{"name":"Department of Pathology Osaka University Graduate School of Medicine Osaka Japan"},{"name":"RNA Frontier Science Division, Institute for Open and Transdisciplinary Research Initiatives (OTRI) Osaka University Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,5]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2021.7148"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000002064"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12274523"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/1743-422X-8-481"},{"key":"e_1_2_14_6_1","volume-title":"StatPearls [homepage on the Internet]","author":"Saleh D.","year":"2025"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2003.05355.x"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0000000000001359"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.5582\/irdr.2020.03086"}],"container-title":["Pathology International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pin.70146","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/pin.70146","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pin.70146","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T09:47:40Z","timestamp":1785404860000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pin.70146"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":8,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1111\/pin.70146"],"URL":"https:\/\/doi.org\/10.1111\/pin.70146","archive":["Portico"],"relation":{},"ISSN":["1320-5463","1440-1827"],"issn-type":[{"value":"1320-5463","type":"print"},{"value":"1440-1827","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"2026-01-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70146"}}