{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T10:06:51Z","timestamp":1785406011144,"version":"3.56.0"},"reference-count":31,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T00:00:00Z","timestamp":1784592000000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP 25K18737"],"award-info":[{"award-number":["JP 25K18737"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Clusters of epithelial cells of the fallopian tube exhibiting aberrant p53 expression, termed \u201cp53 signatures,\u201d are detected at a relatively high frequency and have been regarded as putative precursors of high\u2010grade serous carcinoma (HGSC). In contrast, the recently proposed \u201c\u03b2\u2010catenin signature\u201d represents a distinct tubal epithelial alteration characterized by the aberrant expression of \u03b2\u2010catenin, the biological significance of which remains unclear. To clarify the frequency and spatial relationship between the two lesions, we analyzed 30 consecutive risk\u2010reducing salpingo\u2010oophorectomy specimens from\n                    <jats:italic>BRCA1\/2<\/jats:italic>\n                    mutation carriers using the sectioning and extensively examining the fimbriated end protocol and performed immunohistochemical evaluation for p53, \u03b2\u2010catenin, and Ki\u201067. p53 signatures and \u03b2\u2010catenin signatures were each identified in seven cases (23%). Two cases (6.7%) harbored both lesions; however, no spatial overlap or histological continuity was observed. Neither lesion demonstrated significant associations with\n                    <jats:italic>BRCA<\/jats:italic>\n                    mutation subtype, age, body mass index, or parity. Furthermore, no cases showed serous tubal intraepithelial lesion, serous tubal intraepithelial carcinoma, or HGSC. These findings suggest that p53 signatures and \u03b2\u2010catenin signatures may represent distinct localized epithelial alterations in the fallopian tube, although further molecular and spatial analyses are required to clarify their biological relationship.\n                  <\/jats:p>","DOI":"10.1111\/pin.70152","type":"journal-article","created":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T05:48:02Z","timestamp":1784699282000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prevalence and Independence of p53 Signatures and \u03b2\u2010Catenin Signatures in Risk\u2010Reducing Salpingo\u2010Oophorectomy Specimens"],"prefix":"10.1111","volume":"76","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-1859-094X","authenticated-orcid":false,"given":"Kei","family":"Koyama","sequence":"first","affiliation":[{"name":"Department of Quantitative Pathology, Graduate School of Medicine Akita University Akita Akita 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Graduate School of Medicine Akita University Akita Akita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Department of Quantitative Pathology, Graduate School of Medicine Akita University Akita Akita Japan"},{"name":"Department of Health Sciences, Course of Occupational Therapy Akita University Graduate School of Health Sciences Akita Akita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukitsugu","family":"Kudo\u2010Asabe","sequence":"additional","affiliation":[{"name":"Department of Quantitative Pathology, Graduate School of Medicine Akita University Akita Akita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Nanjo","sequence":"additional","affiliation":[{"name":"Department of Pathology Akita University Hospital Akita Akita 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