{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T10:06:51Z","timestamp":1785406011078,"version":"3.56.0"},"reference-count":19,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T00:00:00Z","timestamp":1785110400000},"content-version":"vor","delay-in-days":26,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82473472"],"award-info":[{"award-number":["82473472"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Bronchiolar adenoma (BA) is a generally benign peripheral lung neoplasm with a bilayered structure of basal and luminal cells. Recently, an increasing number of bronchiolar adenoma\u2014like tumor with squamous epithelial metaplasia (BATSM) have been reported, raising the question of whether they represent variant subtypes of BA or potentially novel tumor entities. Pulmonary metastasis of ameloblastoma (MA) shares morphological similarities with BATSM, exhibiting TTF\u20101\/Napsin A\u2010positive luminal cells and P40\/P63\u2010positive basal cells; this overlap can lead to misdiagnosis of MA as BATSM. We collected 5 MA and 10 BATSM cases, analyzing their morphology, immunohistochemistry, elastic fiber staining and molecular pathology. MA presents as well\u2010circumscribed bronchiole\u2010unrelated nodules with alveolar destruction, intraluminal serous secretions, and Calretinin\u2010positive stellate reticulum\u2010like cells. BATSM is bronchiole\u2010associated, preserves alveolar architecture, and is Calretinin\u2010negative with weak basal TTF\u20101 positivity. 80% of MA cases harbored BRAF V600E mutations; 30% of BATSM cases exhibited EGFR exon 20 insertions. This study highlights the need for integrating clinical history, morphology, immunohistochemistry and molecular testing to avoid misdiagnosing MA as BATSM.<\/jats:p>","DOI":"10.1111\/pin.70155","type":"journal-article","created":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T11:40:18Z","timestamp":1785152418000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Pulmonary Metastasizing Ameloblastomas Can Masquerade as Certain Bronchiolar Adenoma\u2010Like Tumor With Squamous Epithelial Metaplasia"],"prefix":"10.1111","volume":"76","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6538-7996","authenticated-orcid":false,"given":"Shengnan","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Pathology Shanghai Pulmonary Hospital, Tongji University School of Medicine Shanghai People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianjun","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pathology Shanghai Pulmonary Hospital, Tongji University School of Medicine Shanghai People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1797-8342","authenticated-orcid":false,"given":"Likun","family":"Hou","sequence":"additional","affiliation":[{"name":"Department of Pathology Shanghai Pulmonary Hospital, Tongji University School of Medicine Shanghai People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Pathology Shanghai Pulmonary Hospital, Tongji University School of Medicine Shanghai People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8394-7539","authenticated-orcid":false,"given":"Zhengwei","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Pathology Shanghai Pulmonary Hospital, Tongji University School of Medicine Shanghai People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Pathology Shanghai Pulmonary Hospital, Tongji University School of Medicine Shanghai People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pathology Shanghai Pulmonary Hospital, Tongji University School of Medicine Shanghai People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1109-0905","authenticated-orcid":false,"given":"Chunyan","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Pathology Shanghai Pulmonary Hospital, Tongji University School of Medicine Shanghai People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6007-3418","authenticated-orcid":false,"given":"Huikang","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Pathology Shanghai Pulmonary Hospital, Tongji University School of Medicine Shanghai People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,27]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001086"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/pin.12512"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2021.11.003"},{"issue":"10","key":"e_1_2_9_5_1","first-page":"1024","article-title":"Clinical and Pathological Analysis of 4 Cases of Bronchiolar Adenoma With Atypical and Malignant Components","volume":"53","author":"Jing Z.","year":"2024","journal-title":"Chinese Journal of Pathology"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.14890"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.12998\/wjcc.v11.i1.233"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.14907"},{"issue":"6","key":"e_1_2_9_9_1","first-page":"783","article-title":"Clinicopathological Analysis of Bronchiolar Adenoma Combined With Lung Adenocarcinoma: Report of Eight Cases and Literature Review","volume":"39","author":"Zhu M.","year":"2024","journal-title":"Histology and Histopathology"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13000-015-0367-0"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000036559"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.14806"},{"issue":"4","key":"e_1_2_9_13_1","first-page":"368","article-title":"Clinical and Molecular Characteristics of Bronchial Adenoma: An Analysis of 88 Cases","volume":"54","author":"Xu Q. 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