{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T13:41:33Z","timestamp":1792590093874,"version":"4.5.0"},"reference-count":30,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T00:00:00Z","timestamp":1792540800000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    This study clarifies the distinct clinicopathological and molecular features of amphicrine pancreatic carcinoma (AmpCA) through a case analysis and literature review. We present a case of AmpCA in a 73\u2010year\u2010old female, characterized by co\u2010expression of acinar cell markers and neuroendocrine markers within individual tumor cells. Molecular profiling revealed high\u2010risk mutations in\n                    <jats:italic>KRAS<\/jats:italic>\n                    G12V,\n                    <jats:italic>TP53<\/jats:italic>\n                    , and\n                    <jats:italic>RB1<\/jats:italic>\n                    , along with a high Ki\u201067 index (85%). Literature comparison confirms that AmpCA exhibits a unique bidirectional, single\u2010cell differentiation pattern, fundamentally distinguishing it from the bicellular composition of mixed neuroendocrine\u2010non\u2010neuroendocrine neoplasms (MiNEN). We conclude that AmpCA is a distinct malignant entity requiring specific diagnostic criteria, and its molecular profile suggests potential for targeted therapies.\n                  <\/jats:p>","DOI":"10.1111\/pin.70182","type":"journal-article","created":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T12:58:23Z","timestamp":1792587503000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Amphicrine Carcinomas of the Pancreas Showing Neuroendocrine and Acinar Cell Differentiation: A Case Report and Literature Review"],"prefix":"10.1111","volume":"76","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-9482-2612","authenticated-orcid":false,"given":"Yayu","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Hepatobiliary Pancreatic Surgery Changhai Hospital Shanghai Yangpu District China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Pancreatic Surgery Changhai Hospital Shanghai Yangpu District China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenxi","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Pancreatic Surgery Changhai Hospital Shanghai Yangpu District China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-5215-0019","authenticated-orcid":false,"given":"Keke","family":"Lv","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Pancreatic Surgery Changhai Hospital Shanghai Yangpu District China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Pathology Changhai Hospital Affiliated to Navy Medical University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianlin","family":"He","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Pancreatic Surgery Changhai Hospital Shanghai Yangpu District China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,21]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2010.127"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/1757-1626-0002-0000006481"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v26.i34.5181"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-198700111-00007"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199408000-00002"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.2147\/ott.S87406"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12022-016-9432-9"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19821115)50:10<2099::aid-cncr2820501021>3.0.co;2-1"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19881101)62:9<1999::aid-cncr2820620921>3.0.co;2-j"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0046-8177(88)80240-5"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12022-023-09766-0"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1699-0463.1992.tb00880.x"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/83.1.95"},{"issue":"5","key":"e_1_2_11_15_1","first-page":"424","article-title":"[Amphicrine Carcinoma of the Pancreas. 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