{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T02:51:40Z","timestamp":1791168700206,"version":"4.1.0"},"reference-count":20,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T00:00:00Z","timestamp":1790294400000},"content-version":"vor","delay-in-days":24,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Hybrid low\u2010grade fibromyxoid sarcoma\/sclerosing epithelioid fibrosarcoma (LGFMS\/SEF) is an ultra\u2010rare fibroblastic sarcoma that typically arises in the soft tissues. Primary involvement of the respiratory tract is extremely uncommon, and, to our knowledge, no cases arising in the bronchial wall have previously been reported. We describe a hybrid LGFMS\/SEF arising in the right bronchus of a Japanese woman in her 40\u2009s. The 2\u2010cm tumor was incidentally detected, and imaging studies demonstrated no other lesions. Histologically, the tumor consisted predominantly of bland spindle cells within fibromyxoid stroma with collagen rosettes, admixed with epithelioid fibroblasts arranged in cords. Immunohistochemically, the tumor showed diffuse positivity for MUC4. Comprehensive genomic profiling performed for diagnostic purposes identified an\n                    <jats:italic>EWSR1::CREB3L1<\/jats:italic>\n                    fusion gene, supporting the diagnosis of hybrid LGFMS\/SEF. Retrospective review of the transbronchial biopsy specimen revealed subtle spindle cells showing MUC4 expression by immunohistochemistry and\n                    <jats:italic>EWSR1<\/jats:italic>\n                    rearrangement by fluorescence in situ hybridization, which had initially been interpreted as inflammatory change. This case highlights important diagnostic pitfalls of hybrid LGFMS\/SEF and provides the clinicopathological insights into\n                    <jats:italic>EWSR1::CREB3L1<\/jats:italic>\n                    \u2010associated fibroblastic sarcoma arising in the bronchial wall.\n                  <\/jats:p>","DOI":"10.1111\/pin.70185","type":"journal-article","created":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T14:38:22Z","timestamp":1790347102000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Primary Bronchial Hybrid Low\u2010Grade Fibromyxoid Sarcoma\/Sclerosing Epithelioid Fibrosarcoma With\n                    <i>EWSR1::CREB3L1<\/i>\n                    Fusion: Diagnostic Insights From a Challenging Case in the Respiratory Tract"],"prefix":"10.1111","volume":"76","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7105-6376","authenticated-orcid":false,"given":"Hiroko","family":"Ikeda","sequence":"first","affiliation":[{"name":"Department of Diagnostic Pathology Kanazawa University Hospital Kanazawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6697-3759","authenticated-orcid":false,"given":"Seiichi","family":"Kakegawa","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery Kanazawa University Kanazawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisuke","family":"Saito","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery Kanazawa University Kanazawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keita","family":"Kinoshita","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology Kanazawa University Hospital Kanazawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayumi","family":"Ito","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology Kanazawa University Hospital Kanazawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-2432-5421","authenticated-orcid":false,"given":"Keishi","family":"Mizuguchi","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology Kanazawa University Hospital Kanazawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6151-2988","authenticated-orcid":false,"given":"Seiji","family":"Yano","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Kanazawa University Kanazawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-5663-6679","authenticated-orcid":false,"given":"Tomohiro","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Department of Radiology Kanazawa University Graduate School of Medicine Kanazawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7759-399X","authenticated-orcid":false,"given":"Satoshi","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Department of Radiology Kanazawa University Graduate School of Medicine Kanazawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4805-9787","authenticated-orcid":false,"given":"Akihiro","family":"Nishiyama","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Kanazawa University Hospital Kanazawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinji","family":"Takeuchi","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Kanazawa University Hospital Kanazawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isao","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery Kanazawa University Kanazawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,25]]},"reference":[{"key":"e_1_2_10_2_1","first-page":"127","volume-title":"WHO Classification of Soft Tissue and Bone Tumours","author":"Doyle L. 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