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In <jats:italic>Arabidopsis thaliana<\/jats:italic>, putrescine is synthesised exclusively by arginine decarboxylase (<jats:styled-content style=\"fixed-case\">ADC<\/jats:styled-content>), which exists as two isoforms (<jats:italic><jats:styled-content style=\"fixed-case\">ADC<\/jats:styled-content>1<\/jats:italic> and <jats:italic>2<\/jats:italic>) that are differentially regulated by abiotic stimuli, but their role in defence against pathogens has not been studied in depth. This work analysed the participation of <jats:styled-content style=\"fixed-case\">ADC<\/jats:styled-content> in <jats:italic>Arabidopsis<\/jats:italic> defence against <jats:italic>Pseudomonas viridiflava<\/jats:italic>. <jats:styled-content style=\"fixed-case\">ADC<\/jats:styled-content> activity and expression, polyamine levels and bacterial resistance were analysed in null mutants of each <jats:styled-content style=\"fixed-case\">ADC<\/jats:styled-content> isoform. In non\u2010infected wild\u2010type (<jats:styled-content style=\"fixed-case\">WT<\/jats:styled-content>) plants, <jats:italic><jats:styled-content style=\"fixed-case\">ADC<\/jats:styled-content>2<\/jats:italic> expression was much higher than <jats:italic><jats:styled-content style=\"fixed-case\">ADC<\/jats:styled-content>1<\/jats:italic>. Analysis of <jats:italic>adc<\/jats:italic> mutants demonstrated that <jats:styled-content style=\"fixed-case\">ADC<\/jats:styled-content>2 contributes to a much higher extent than <jats:styled-content style=\"fixed-case\">ADC<\/jats:styled-content>1 to basal <jats:styled-content style=\"fixed-case\">ADC<\/jats:styled-content> activity and putrescine biosynthesis. In addition, <jats:italic>adc2<\/jats:italic> mutants showed increased basal expression of salicylic acid\u2010 and jasmonic acid\u2010dependent <jats:styled-content style=\"fixed-case\">PR<\/jats:styled-content> genes. Bacterial infection induced putrescine accumulation and <jats:italic><jats:styled-content style=\"fixed-case\">ADC<\/jats:styled-content>1<\/jats:italic> expression in <jats:styled-content style=\"fixed-case\">WT<\/jats:styled-content> plants, but pathogen\u2010induced putrescine accumulation was blocked in <jats:italic>adc1<\/jats:italic> mutants. Results suggest a specific participation of <jats:styled-content style=\"fixed-case\">ADC<\/jats:styled-content>1 in defence, although basal resistance was not decreased by dysfunction of either of the two <jats:italic><jats:styled-content style=\"fixed-case\">ADC<\/jats:styled-content><\/jats:italic> genes. In addition, and as opposed to <jats:styled-content style=\"fixed-case\">WT<\/jats:styled-content> plants, bacterial infection increased <jats:italic><jats:styled-content style=\"fixed-case\">ADC<\/jats:styled-content>2<\/jats:italic> expression and <jats:styled-content style=\"fixed-case\">ADC<\/jats:styled-content> activity in <jats:italic>adc1<\/jats:italic> mutants, which could counterbalance the lack of <jats:styled-content style=\"fixed-case\">ADC<\/jats:styled-content>1. Results demonstrate a major contribution of <jats:styled-content style=\"fixed-case\">ADC<\/jats:styled-content>2 to total <jats:styled-content style=\"fixed-case\">ADC<\/jats:styled-content> activity and the specific induction of <jats:styled-content style=\"fixed-case\">ADC<\/jats:styled-content>1 in response to infection. A certain degree of functional redundancy between the two isoforms in relation to their contribution to basal resistance is also evident.<\/jats:p>","DOI":"10.1111\/plb.12289","type":"journal-article","created":{"date-parts":[[2014,11,20]],"date-time":"2014-11-20T07:30:58Z","timestamp":1416468658000},"page":"831-839","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Role of Arginine decarboxylase (<scp>ADC<\/scp>) in <i>Arabidopsis thaliana<\/i> defence against the pathogenic bacterium <i>Pseudomonas viridiflava<\/i>"],"prefix":"10.1111","volume":"17","author":[{"given":"F. R.","family":"Rossi","sequence":"first","affiliation":[{"name":"Instituto de Investigaciones Biotecnol\u00f3gicas\u2010Instituto Tecnol\u00f3gico Chascom\u00fas Universidad Nacional de General San Mart\u00edn\u2010Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (IIB\u2010INTECH\/UNSAM\u2010CONICET) Chascom\u00fas Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Marina","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones Biotecnol\u00f3gicas\u2010Instituto Tecnol\u00f3gico Chascom\u00fas Universidad Nacional de General San Mart\u00edn\u2010Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (IIB\u2010INTECH\/UNSAM\u2010CONICET) Chascom\u00fas Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F. 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