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However, recent findings with pharmacological approaches highlight the non\u2010specificity of commonly used inhibitors. This suggests that caution is required for interpreting these studies and that the use of pharmacological agents is a \u2018double\u2010edged\u2019 tool. On one hand, non\u2010specific effects make interpretation difficult unless other experiments, such as with different mutants or with multiple diversely acting chemicals, are conducted. On the other hand, the non\u2010specificity of inhibitors opens up the possibility of uncovering some ligands or modulators of new receptors such as plant glutamate\u2010like receptors and importance of some metabolic hubs in carbon and nitrogen metabolism such as the pyridoxal phosphate biosynthesis involved in the regulation of the root morphogenetic programme. Identification of such targets is a critical issue to improve the efficiency of absorption of macronutrients in relation to root the morphogenetic programme.<\/jats:p>","DOI":"10.1111\/plb.12405","type":"journal-article","created":{"date-parts":[[2015,10,5]],"date-time":"2015-10-05T08:24:42Z","timestamp":1444033482000},"page":"353-361","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Non\u2010specificity of ethylene inhibitors: \u2018double\u2010edged\u2019 tools to find out new targets involved in the root morphogenetic programme"],"prefix":"10.1111","volume":"18","author":[{"given":"E.","family":"Le Deunff","sequence":"first","affiliation":[{"name":"Normandie Universit\u00e9 UMR EVA F\u201014032 Caen cedex France"},{"name":"INRA, UMR 950, \u00c9cophysiologie V\u00e9g\u00e9tale &amp; Agronomie, Nutritions NCS INRA F\u201014032 Caen cedex 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