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On the day of opening, the <jats:italic>Sauromatum<\/jats:italic> appendix becomes hot, reaching up to 32\u2009\u00b0C. Aspirin, salicylic acid and 2,6\u2010dihydroxybenzoic acid, a subclass of <jats:styled-content style=\"fixed-case\">NSAIDs<\/jats:styled-content>, induce a temperature rise from three mitochondrial sources: alternative oxidase, <jats:styled-content style=\"fixed-case\">F<jats:sub>1<\/jats:sub>F<jats:sub>O<\/jats:sub>\u2010ATP<\/jats:styled-content> synthase and adenine nucleotide translocator. This temperature rise is synchronized and compounded under various light\/dark regimes. We studied the effect of different subgroups of <jats:styled-content style=\"fixed-case\">NSAIDs<\/jats:styled-content> on the temperature rise.<\/jats:p><\/jats:list-item>\n\n<jats:list-item><jats:p>Tissue slices of <jats:italic>appendix of Sauromatum<\/jats:italic> and <jats:italic>Arum<\/jats:italic> <jats:italic>italicum<\/jats:italic> inflorescences at a pre\u2010mature stage were treated with the three inducers in combination with one <jats:styled-content style=\"fixed-case\">NSAID<\/jats:styled-content> under constant light or darkness and under different photoperiods.<\/jats:p><\/jats:list-item>\n\n<jats:list-item><jats:p>Temperature rise generated by the three heat sources in the presence of inducers and different non\u2010selective\u2009NSAIDs were not compounded and occurred at three different times. Under constant light, DuP\u2010697, ibuprofen, flurbiprofen, acetaminophen and diclofenac suppressed the temperature rise induced by the three salicylates. Desynchronization and delayed temperature rise were detected with 6\/42\u2010h light\/ dark and 15\/33\u2010h light\/dark regimes in the presence of celecoxib and ibuprofen. With a 24\/24\u2010h light\/dark regime, temperature rise was suppressed in the presence of ibuprofen. There were differences in response to individual NSAIDs between appendix tissue of <jats:italic>A. italicum<\/jats:italic> and <jats:italic>S. venosum<\/jats:italic>.<\/jats:p><\/jats:list-item>\n\n<jats:list-item><jats:p>Mitochondrial energy balance is affected by NSAIDs. There is an interaction between light\/dark regime and temperature rise and a relationship between timing mechanism and temperature rise.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p>","DOI":"10.1111\/plb.13466","type":"journal-article","created":{"date-parts":[[2022,9,8]],"date-time":"2022-09-08T14:24:27Z","timestamp":1662647067000},"page":"152-160","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Nonsteroidal anti\u2010inflammatory drugs as antipyretics and modulators of a molecular clock(s) in the appendix of <i>Sauromatum venosum<\/i> inflorescence"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3189-2710","authenticated-orcid":false,"given":"H.","family":"Skubatz","sequence":"first","affiliation":[{"name":"NeoPro Labs  Seattle WA 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