{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T16:53:46Z","timestamp":1790182426212,"version":"4.1.0"},"reference-count":42,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,1,22]],"date-time":"2025-01-22T00:00:00Z","timestamp":1737504000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Plant Biol J"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Isoleucic acid (ILA) was identified in human patients with maple syrup urine disease (MSUD) half a century ago. MSUD patients, who are defective in the catabolism of branched\u2010chain amino acids (BCAAs), that is, isoleucine, leucine, and valine, have urine with a unique maple syrup odour related to the accumulation of BCAA breakdown products, largely 2\u2010keto acid derivatives and their reduced 2\u2010hydroxy acids including ILA. A decade ago, ILA was identified in <jats:italic>Arabidopsis thaliana<\/jats:italic>. Subsequent studies in other plant species indicated that ILA is a ubiquitously present compound. Since its identification in plants, several efforts have been made to understand the biological significance and metabolic pathway of ILA. ILA plays a positive role in plant signalling for defence responses against bacterial pathogens by increasing the abundance of salicylic acid aglycone through competitive inhibition of SA deactivation by glucosylation. Here, we review recent progress in the characterization of ILA biosynthesis and function in plants and discuss current knowledge gaps and future directions in ILA research.<\/jats:p>","DOI":"10.1111\/plb.13771","type":"journal-article","created":{"date-parts":[[2025,1,23]],"date-time":"2025-01-23T07:43:01Z","timestamp":1737618181000},"page":"195-202","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The branched\u2010chain amino acid\u2010related isoleucic acid: recent research advances"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3167-7412","authenticated-orcid":false,"given":"D. W.","family":"Mekonnen","sequence":"first","affiliation":[{"name":"Division of Agricultural Biotechnology, Institute of Biotechnology Bahir Dar University  Bahir Dar Ethiopia"},{"name":"Department of Environmental Health, Institute of Biochemical Plant Pathology Helmholtz Zentrum M\u00fcnchen  Neuherberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Ghirardo","sequence":"additional","affiliation":[{"name":"Department of Environmental Health, Research Unit Environmental Simulation Helmholtz Zentrum M\u00fcnchen  Neuherberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Environmental Health, Institute of Biochemical Plant Pathology Helmholtz Zentrum M\u00fcnchen  Neuherberg Germany"},{"name":"College of Life Sciences Jiangsu University  Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. 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