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It is rich in specialized metabolites with medicinal properties. Indeed, alkaloids and flavonoids are phytochemical markers of the genus. Our previous studies identified key biochemical and molecular targets in biosynthesis of these metabolites in\n                          <jats:italic>E. velutina<\/jats:italic>\n                          , including phytohormone signalling pathways and responses to environmental stressors. However, the role of these signalling molecules and external factors in modulating the tree natural product (NP) profiles remains unexplored.\n                        <\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>\n                          In this study, seedlings of\n                          <jats:italic>E. velutina<\/jats:italic>\n                          were subjected to environmental stress (heat, ultraviolet radiation, drought, salinity, mechanical damage) and phytohormone exposure (methyl jasmonate, salicylic acid, nitric oxide, abscisic acid). Leaves and roots were collected after 2 and 4\u2009days of treatment for HPLC\u2010DAD and chemometric analyses.\n                        <\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>The most prominent factors that increased accumulation of major metabolites were nitric oxide, drought, heat, ultraviolet radiation, and methyl jasmonate. The analyses revealed both organ\u2010 and temporal\u2010specific metabolite profiles, as well as some typically shared features. Both phytoanticipin and phytoalexin\u2010like metabolite profiles were recorded, with prevalence of the former.<\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>\n                          The results shed light on how the above factors affect metabolic tuning in\n                          <jats:italic>E. velutina<\/jats:italic>\n                          . Moreover, the generated datasets will be useful in selecting individual compounds for detailed functional investigation, as well as for directing chemical profiles towards known and novel metabolites of interest in this species.\n                        <\/jats:p>\n                      <\/jats:list-item>\n                    <\/jats:list>\n                  <\/jats:p>","DOI":"10.1111\/plb.70104","type":"journal-article","created":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T19:49:12Z","timestamp":1757360952000},"page":"1326-1340","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Environmental and phytohormone modulation of organ\u2010specific specialized metabolite profiles in the dryland tree\n                    <i>Erythrina velutina<\/i>"],"prefix":"10.1111","volume":"27","author":[{"given":"D. S.","family":"Chacon","sequence":"first","affiliation":[{"name":"Department of Pharmacy Federal University of Rio Grande do Norte (UFRN)  Natal Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Bonilauri","sequence":"additional","affiliation":[{"name":"Department of Medicine, Stanford Cardiovascular Institute Stanford University School of Medicine  Stanford California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. T.","family":"da Costa","sequence":"additional","affiliation":[{"name":"Department of Botany and Center for Biotechnology, Plant Physiology Laboratory Federal University of Rio Grande do Sul  Porto Alegre Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Vilasboa","sequence":"additional","affiliation":[{"name":"Department of Botany and Center for Biotechnology, Plant Physiology Laboratory Federal University of Rio Grande do Sul  Porto Alegre Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Koetz","sequence":"additional","affiliation":[{"name":"Department of Raw Material Production, Faculty of Pharmacy, Laboratory of Pharmacognosy Federal University of Rio Grande do Sul  Porto Alegre Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Pinto","sequence":"additional","affiliation":[{"name":"Department of Analytical Chemistry (DQA) State University of Rio de Janeiro (UERJ)  Rio de Janeiro Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. A. S.","family":"Zuanazzi","sequence":"additional","affiliation":[{"name":"Department of Raw Material Production, Faculty of Pharmacy, Laboratory of Pharmacognosy Federal University of Rio Grande do Sul  Porto Alegre Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6500-0755","authenticated-orcid":false,"given":"R. B.","family":"Giordani","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Federal University of Rio Grande do Norte (UFRN)  Natal Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5477-2610","authenticated-orcid":false,"given":"A. 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