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The biosynthesis of flavonoids has been studied for decades and has developed into a model system in plant biology. Despite thousands of publications about this pathway, there are still open questions about fundamental aspects of anthocyanin biosynthesis. Here, we review the evolution of anthocyanin biosynthesis and highlight key open questions\u2013some of which are sitting in plain sight.<\/jats:p>","DOI":"10.1111\/plb.70283","type":"journal-article","created":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T08:59:37Z","timestamp":1788425977000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Almost 200\u2009years of anthocyanin research: What we know, what we assume and what remains unknown"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2562-7905","authenticated-orcid":false,"given":"N.","family":"Choudhary","sequence":"first","affiliation":[{"name":"Plant Biotechnology and Bioinformatics Institute for Cellular and Molecular Botany (IZMB), University of Bonn  Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-3003-3338","authenticated-orcid":false,"given":"N.","family":"Khatun","sequence":"additional","affiliation":[{"name":"Plant Biotechnology and Bioinformatics Institute for Cellular and Molecular Botany (IZMB), University of Bonn  Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3321-7471","authenticated-orcid":false,"given":"B.","family":"Pucker","sequence":"additional","affiliation":[{"name":"Plant Biotechnology and Bioinformatics Institute for Cellular and Molecular Botany (IZMB), University of Bonn  Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,3]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"crossref","first-page":"2228","DOI":"10.1111\/nph.17648","article-title":"Anthocyanins in photoprotection: knowing the actors in play to solve 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