{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T06:20:19Z","timestamp":1787984419818,"version":"build-2784847793"},"reference-count":35,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2012,9,24]],"date-time":"2012-09-24T00:00:00Z","timestamp":1348444800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Paediatric Perinatal Epid"],"published-print":{"date-parts":[[2012,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background:\u2002<\/jats:bold> Complete atrioventricular canal defects (CAVC) are a common heart defect, but few epidemiologic studies have evaluated non\u2010syndromic CAVC. Risk factors for non\u2010syndromic CAVC have not been well established.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> To assess the relationship between risk for non\u2010syndromic CAVC in offspring and several sociodemographic and reproductive parental factors, including maternal diabetes and obesity, we conducted Poisson regression analyses, using data ascertained through the Texas Birth Defects Registry, a large, population\u2010based birth defects registry. Data were evaluated for 563 non\u2010syndromic cases with CAVC.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Significant associations were observed between non\u2010syndromic CAVC in offspring and maternal pregestational diabetes (adjusted prevalence ratio (aPR) 6.74; 95% confidence interval (CI) 3.67, 12.37), gestational diabetes (aPR 1.69; 95% CI 1.03, 2.79) and obesity (aPR 1.69; 95% CI 1.24, 2.30).<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> Our findings add non\u2010syndromic CAVC to the growing list of birth defects that appear to be associated with maternal diabetes and obesity.<\/jats:p>","DOI":"10.1111\/ppe.12006","type":"journal-article","created":{"date-parts":[[2012,9,25]],"date-time":"2012-09-25T03:54:39Z","timestamp":1348545279000},"page":"515-524","source":"Crossref","is-referenced-by-count":32,"title":["Descriptive Epidemiology of Non\u2010syndromic Complete Atrioventricular Canal Defects"],"prefix":"10.1111","volume":"26","author":[{"given":"A. 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