{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T07:00:55Z","timestamp":1788246055117,"version":"build-2803163510"},"reference-count":48,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2012,12,12]],"date-time":"2012-12-12T00:00:00Z","timestamp":1355270400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Paediatric Perinatal Epid"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>It remains unclear whether maternal hypertensive disorders could impact cognitive development of the child. The aim of this study was to explore the association between hypertensive disorders and other maternal biological and social factors on the risk of mild cognitive limitations (intelligence quotient 50\u201385) in the offspring.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>An 11.5\u2010year follow\u2010up study of the <jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>orthern <jats:styled-content style=\"fixed-case\">F<\/jats:styled-content>inland <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>irth <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>ohort 1986 (<jats:italic><jats:styled-content style=\"fixed-case\">n<\/jats:styled-content><\/jats:italic>\u2009=\u20099432) was utilised. The analysis included 8847 singleton children, of whom 198 had mild cognitive limitations. Gestational hypertension was defined as <jats:italic>de novo<\/jats:italic> hypertension (blood pressure\u2009\u2265\u2009140\/90), diagnosed mid\u2010pregnancy in a previously normotensive woman. Data on intelligence level of the children were based on standardised intelligence test results.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eleven per cent (<jats:italic>n<\/jats:italic>\u2009=\u200920) of mothers having a child with mild cognitive limitations had gestational hypertension. Maternal gestational hypertension was independently associated with increased odds of mild cognitive limitation in the offspring (odds ratio 2.4 [95% confidence interval 1.4, 3.9]). Other independent maternal risk factors for mild cognitive limitation were high pre\u2010pregnancy body mass index (\u226530\u2009kg\/m<jats:sup>2<\/jats:sup>), multiparity (\u22654) and low education. In addition family's socio\u2010economic status lower than professional, male gender and small birthweight\u2010for\u2010gestational age appeared as independent risk factors for mild cognitive limitation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Gestational hypertension should be considered as one of the adverse early risk factors that may predispose to impaired cognitive development in childhood.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ppe.12028","type":"journal-article","created":{"date-parts":[[2012,12,13]],"date-time":"2012-12-13T22:32:47Z","timestamp":1355437967000},"page":"188-198","source":"Crossref","is-referenced-by-count":44,"title":["Maternal Hypertensive Disorders during Pregnancy and Mild Cognitive Limitations in the Offspring"],"prefix":"10.1111","volume":"27","author":[{"given":"Ulla","family":"Heikura","sequence":"first","affiliation":[{"name":"Institute of Health Sciences University of Oulu  Finland"},{"name":"Verve Oulu  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