{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T07:09:39Z","timestamp":1789715379673,"version":"4.0.1"},"reference-count":35,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,4,10]],"date-time":"2013-04-10T00:00:00Z","timestamp":1365552000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Paediatric Perinatal Epid"],"published-print":{"date-parts":[[2013,5]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Results of previous population\u2010based studies examining associations between smoking during pregnancy and autism spectrum disorders (ASD<\/jats:styled-content>) are contradictory. Furthermore, there is a lack of population\u2010based studies examining the relationship between smoking during pregnancy and the main diagnostic subtypes of ASD<\/jats:styled-content>.<\/jats:p><\/jats:sec>Methods<\/jats:title>We conducted a population\u2010based nested case\u2013control study based on the F<\/jats:styled-content>innish P<\/jats:styled-content>renatal S<\/jats:styled-content>tudy of A<\/jats:styled-content>utism (FIPS<\/jats:styled-content>\u2010A<\/jats:styled-content>) among liveborn infants delivered in F<\/jats:styled-content>inland between 1987 and 2005. Data on maternal smoking during pregnancy were available from the F<\/jats:styled-content>innish M<\/jats:styled-content>edical B<\/jats:styled-content>irth R<\/jats:styled-content>egister (FMBR<\/jats:styled-content>) since O<\/jats:styled-content>ctober 1990. Data on ASD<\/jats:styled-content> in the offspring were obtained from the F<\/jats:styled-content>innish H<\/jats:styled-content>ospital D<\/jats:styled-content>ischarge R<\/jats:styled-content>egister (FHDR<\/jats:styled-content>).<\/jats:p><\/jats:sec>Results<\/jats:title>Among the three subtypes of ASD<\/jats:styled-content>, maternal smoking during the whole pregnancy was associated with an increased risk of pervasive developmental disorder (PDD<\/jats:styled-content>) (odds ratio 1.2, 95% confidence interval 1.0, 1.5). The increase in odds persisted after controlling for maternal age, mother's socio\u2010economic and psychiatric status, and infant's weight for gestational age. However, smoking exposure limited to the first trimester was not associated with PDD<\/jats:styled-content> or any of the other ASD<\/jats:styled-content> subtypes.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Maternal smoking is related to a modest increase in risk of PDD<\/jats:styled-content>, while no associations were observed for childhood autism and A<\/jats:styled-content>sperger's syndrome.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ppe.12043","type":"journal-article","created":{"date-parts":[[2013,4,10]],"date-time":"2013-04-10T10:07:39Z","timestamp":1365588459000},"page":"266-274","source":"Crossref","is-referenced-by-count":62,"title":["Smoking during Pregnancy and Risk of A<\/scp>utism S<\/scp>pectrum D<\/scp>isorder in a F<\/scp>innish N<\/scp>ational B<\/scp>irth C<\/scp>ohort"],"prefix":"10.1111","volume":"27","author":[{"given":"Phuong Lien","family":"Tran","sequence":"first","affiliation":[{"name":"University Joseph Fourier Grenoble France"},{"name":"Department of Child Psychiatry University of Turku Turku"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Venla","family":"Lehti","sequence":"additional","affiliation":[{"name":"Department of Child Psychiatry University of Turku Turku"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katja M.","family":"Lampi","sequence":"additional","affiliation":[{"name":"Department of Child Psychiatry University of Turku Turku"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans","family":"Helenius","sequence":"additional","affiliation":[{"name":"Department of Biostatistics University of Turku Turku"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Auli","family":"Suominen","sequence":"additional","affiliation":[{"name":"Department of Child Psychiatry University of Turku Turku"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mika","family":"Gissler","sequence":"additional","affiliation":[{"name":"National Institute of Health and Welfare (THL) Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan S.","family":"Brown","sequence":"additional","affiliation":[{"name":"Department of Psychiatry College of Physicians and Surgeons Columbia University New York NY"},{"name":"New York State Psychiatric Institute Joseph L. Mailman School of Public Health Columbia University New York NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andre","family":"Sourander","sequence":"additional","affiliation":[{"name":"Department of Biostatistics University of Turku Turku"},{"name":"Department of Child Psychiatry Turku University Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,4,10]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1681.2009.05214.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2005.05.004"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfq103"},{"key":"e_1_2_7_5_1","first-page":"359","article-title":"Maternal smoking during pregnancy as an environmental risk factor for attention deficit hyperactivity disorder behaviour. 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