{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T20:23:00Z","timestamp":1784319780697,"version":"3.55.0"},"reference-count":17,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,10,11]],"date-time":"2013-10-11T00:00:00Z","timestamp":1381449600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Paediatric Perinatal Epid"],"published-print":{"date-parts":[[2013,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Low\u2010dose aspirin (<jats:styled-content style=\"fixed-case\">LDA<\/jats:styled-content>) has been proposed to improve pregnancy outcomes in couples experiencing recurrent pregnancy loss. However, results from studies of <jats:styled-content style=\"fixed-case\">LDA<\/jats:styled-content> on pregnancy outcomes have been inconsistent, perhaps because most studies evaluated <jats:styled-content style=\"fixed-case\">LDA<\/jats:styled-content>\u2010initiated post\u2010conception. The purpose of the Effects of Aspirin in Gestation and Reproduction (<jats:styled-content style=\"fixed-case\">EAGeR<\/jats:styled-content>) trial was to determine whether preconception\u2010initiated <jats:styled-content style=\"fixed-case\">LDA<\/jats:styled-content> improves livebirth rates in women with one to two prior losses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a multicentre, block randomised, double\u2010blind, placebo\u2010controlled trial. Study participants were recruited using community\u2010based advertisements and physician referral to four university medical centres in the <jats:styled-content style=\"fixed-case\">US<\/jats:styled-content> (2006\u201312). Eligible women were aged 18\u201340 years actively trying to conceive, with one to two prior losses. Participants were randomised to receive daily <jats:styled-content style=\"fixed-case\">LDA<\/jats:styled-content> (81\u2009mg\/day) or a matching placebo, and all were provided with daily 400\u2010mcg folic acid. Follow\u2010up continued for \u22646 menstrual cycles while attempting to conceive. For those who conceived, treatment was continued until 36 weeks gestation. The primary outcome was the cumulative livebirth rate over the trial period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were 1228 women randomised (615 <jats:styled-content style=\"fixed-case\">LDA<\/jats:styled-content>, 613 placebo). Participants had a mean age of 28.7, were mostly white (95%), well educated (86%\u2009more than\u2009high school education), and employed (75%) with a household income &gt;$100\u2009000 annually (40%). The characteristics of those in the treatment and placebo arms were well balanced.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We describe the study design, recruitment, data collection, and baseline characteristics of participants enrolled in <jats:styled-content style=\"fixed-case\">EAGeR<\/jats:styled-content>, which aimed to determine the effect of <jats:styled-content style=\"fixed-case\">LDA<\/jats:styled-content> on livebirth and other pregnancy outcomes in these women.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ppe.12088","type":"journal-article","created":{"date-parts":[[2013,10,14]],"date-time":"2013-10-14T11:21:12Z","timestamp":1381749672000},"page":"598-609","source":"Crossref","is-referenced-by-count":99,"title":["A Randomised Trial to Evaluate the Effects of Low\u2010dose Aspirin in Gestation and Reproduction: Design and Baseline Characteristics"],"prefix":"10.1111","volume":"27","author":[{"given":"Enrique F.","family":"Schisterman","sequence":"first","affiliation":[{"name":"Epidemiology Branch Division of Intramural Population Health Research Eunice Kennedy Shriver National Institute of Child Health and Human Development  Rockville MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert M.","family":"Silver","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University of Utah  Salt Lake City UT"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil J.","family":"Perkins","sequence":"additional","affiliation":[{"name":"Epidemiology Branch Division of Intramural Population Health Research Eunice Kennedy Shriver National Institute of Child Health and Human Development  Rockville MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunni L.","family":"Mumford","sequence":"additional","affiliation":[{"name":"Epidemiology Branch Division of Intramural Population Health Research Eunice Kennedy Shriver National Institute of Child Health and Human Development  Rockville MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian W.","family":"Whitcomb","sequence":"additional","affiliation":[{"name":"Division of Biostatistics and Epidemiology School of Public Health and Health Sciences University of Massachusetts at Amherst  Amherst MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph B.","family":"Stanford","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University of Utah  Salt Lake City UT"},{"name":"Department of Family and Preventive Medicine University of Utah  Salt Lake City UT"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurie L.","family":"Lesher","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University of Utah  Salt Lake City UT"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Faraggi","sequence":"additional","affiliation":[{"name":"Department of Statistics University of Haifa  Haifa Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"Wactawski\u2010Wende","sequence":"additional","affiliation":[{"name":"Department of Social and Preventive Medicine University at Buffalo  Buffalo NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard W.","family":"Browne","sequence":"additional","affiliation":[{"name":"Department of Biotechnical and Clinical Laboratory Sciences University at Buffalo  Buffalo NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janet M.","family":"Townsend","sequence":"additional","affiliation":[{"name":"Department of Family, Community and Rural Health Commonwealth Medical College  Scranton PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"White","sequence":"additional","affiliation":[{"name":"Department of Family, Community and Rural Health Commonwealth Medical College  Scranton PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne M.","family":"Lynch","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University of Colorado  Denver CO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noya","family":"Galai","sequence":"additional","affiliation":[{"name":"Department of Statistics University of Haifa  Haifa Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,10,11]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"195","volume-title":"Medicine of the Fetus and Mother","author":"Silver 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