{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T12:06:15Z","timestamp":1792065975749,"version":"4.4.0"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,12,20]],"date-time":"2013-12-20T00:00:00Z","timestamp":1387497600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Paediatric Perinatal Epid"],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Placental weight is an independent predictor of adverse perinatal outcome. However, risk factors for high and low placental weight are poorly understood. The objective of this study was to identify maternal, placental, and umbilical cord determinants of placental weight, before and after accounting for birthweight.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This cohort study of 87\u2009600 singleton births at the <jats:styled-content style=\"fixed-case\">R<\/jats:styled-content>oyal <jats:styled-content style=\"fixed-case\">V<\/jats:styled-content>ictoria <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>ospital in <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>ontreal, <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>anada assessed the relationship between maternal, placental, and umbilical cord characteristics and placental weight (standardised for sex and gestational age). We separately examined risk factors for high (<jats:italic>z<\/jats:italic>\u2010score &gt;+1) and low (<jats:italic>z<\/jats:italic>\u2010score &lt;\u22121) placental weight. Multivariable logistic regression was used to study associations after adjusting for confounders and further adjusting for birthweight.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Chronic hypertension was associated with low placental weight {relative risk (<jats:styled-content style=\"fixed-case\">RR<\/jats:styled-content>) 2.1 [95% confidence interval (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>) 1.8, 2.4] and 1.8 [95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.5, 2.1] before and after accounting for birthweight}, while pre\u2010eclampsia was associated with low placenta weight before, but not after adjustment for birthweight. Anaemia and gestational diabetes were linked with high placental weight (<jats:styled-content style=\"fixed-case\">RRs<\/jats:styled-content> 1.2\u20131.4, respectively) before and after adjustment for birthweight, while smoking was linked with high placental weight only after adjustment for birthweight (<jats:styled-content style=\"fixed-case\">RR<\/jats:styled-content> 1.4 [95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.3, 1.5]). Placental and cord determinants of high placental weight included chorioamnionitis, chorangioma\/chorangiosis, circumvallate placenta, marginal cord insertion, and other cord abnormalities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The broad range of risk factors for high placental weight suggests multiple aetiologic pathways. Future work should seek to understand the pathways by which the placenta adapts to unfavourable intrauterine conditions, which may provide insights into potential therapies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ppe.12104","type":"journal-article","created":{"date-parts":[[2013,12,20]],"date-time":"2013-12-20T09:47:59Z","timestamp":1387532879000},"page":"97-105","source":"Crossref","is-referenced-by-count":74,"title":["Risk Factors for High and Low Placental Weight"],"prefix":"10.1111","volume":"28","author":[{"given":"Helen","family":"McNamara","sequence":"first","affiliation":[{"name":"Department of Epidemiology Biostatistics, and Occupational Health University of British Columbia  Vancouver"},{"name":"Department of Obstetrics &amp; Gynecology University of British Columbia  Vancouver"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer A.","family":"Hutcheon","sequence":"additional","affiliation":[{"name":"Department of Obstetrics &amp; Gynaecology University of British Columbia  Vancouver"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert W.","family":"Platt","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Biostatistics, and Occupational Health University of British Columbia  Vancouver"},{"name":"Department of Pediatrics McGill University  Montreal Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice","family":"Benjamin","sequence":"additional","affiliation":[{"name":"Department of Obstetrics &amp; Gynecology University of British Columbia  Vancouver"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael S.","family":"Kramer","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Biostatistics, and Occupational Health University of British Columbia  Vancouver"},{"name":"Department of Pediatrics McGill University  Montreal Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,12,20]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1879-3479.1970.tb00313.x"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(87)80170-3"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1969.tb15722.x"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e318253d3df"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0143-4004(84)80051-X"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.71.4.588"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.310.6977.436"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.314.7098.1864"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/der428"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/det299"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2393-8-44"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2011.03053.x"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1447-0756.2011.01600.x"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/aogs.12105"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/aogs.12194"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016348209156166"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2007.01.048"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b2393"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2010.02701.x"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)60279-6"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2006.00882.x"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/155.3.203"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/aogs.12104"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.2003.014217"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1970.tb03541.x"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0143-4004(05)80643-5"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(70)90045-1"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2009.10.001"},{"key":"e_1_2_5_30_1","first-page":"644","article-title":"Statistical considerations regarding the use of ratios to adjust data","volume":"19","author":"Allison DB","year":"1995","journal-title":"International Journal of Obesity and Related Metabolic Disorders"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.c2289"}],"container-title":["Paediatric and Perinatal Epidemiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fppe.12104","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ppe.12104","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T14:52:04Z","timestamp":1695999124000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ppe.12104"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,12,20]]},"references-count":30,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,3]]}},"alternative-id":["10.1111\/ppe.12104"],"URL":"https:\/\/doi.org\/10.1111\/ppe.12104","archive":["Portico"],"relation":{},"ISSN":["0269-5022","1365-3016"],"issn-type":[{"value":"0269-5022","type":"print"},{"value":"1365-3016","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,12,20]]}}}