{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T02:38:33Z","timestamp":1790735913762,"version":"4.1.0"},"reference-count":48,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,3,13]],"date-time":"2014-03-13T00:00:00Z","timestamp":1394668800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["DK56350"],"award-info":[{"award-number":["DK56350"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Mathile Institute for the Advancement of Human Nutrition"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Paediatric Perinatal Epid"],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Lipid\u2010based nutrient supplements (<jats:styled-content style=\"fixed-case\">LNS<\/jats:styled-content>) have been effective in the treatment of acute malnutrition among children. We evaluated the use of <jats:styled-content style=\"fixed-case\">LNS<\/jats:styled-content> supplementation for improving the micronutrient status of young children.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A 12\u2010month randomised controlled trial was conducted among children aged 6\u201318 months living in <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>ntibuc\u00e1, <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>onduras. Communities (<jats:italic>n<\/jats:italic>\u2009=\u200918) were randomised into clusters matched by poverty indicators (9 intervention, <jats:italic>n<\/jats:italic>\u2009=\u2009160 and 9 controls, <jats:italic>n<\/jats:italic>\u2009=\u2009140). Intervention participants received <jats:styled-content style=\"fixed-case\">LNS<\/jats:styled-content>. All children received food vouchers and nutrition education. Primary outcomes included measures of micronutrient status: at baseline, 6 and 12 months' blood were collected for assessment of folate, iron, zinc, riboflavin, and vitamin <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content><jats:sub>12<\/jats:sub> status; haemoglobin was measured every 3 months; and dietary and anthropometry collected monthly. Longitudinal analyses were based on intent to treat and <jats:styled-content style=\"fixed-case\">LNS<\/jats:styled-content> adherence. Generalised estimating equations were used in the estimation of generalised linear regression models specified for the data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>t 6\u2010month follow\u2010up, children in the intervention group had a lower proportion classified as deficient for <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content><jats:sub>12<\/jats:sub> (43.6%) compared with the control (67.7%; <jats:italic>P<\/jats:italic>\u2009=\u20090.03). The intervention group had a higher mean concentration for folate at 6 months (<jats:italic>P<\/jats:italic>\u2009=\u20090.06), and improvements continued through 12 months for folate (<jats:italic>P<\/jats:italic>\u2009=\u20090.002) and vitamin <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content> deficiency (<jats:italic>P<\/jats:italic>\u2009=\u20090.03). This pattern of results, with improved significance, remained in subanalysis based on <jats:styled-content style=\"fixed-case\">LNS<\/jats:styled-content> adherence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These data demonstrate that <jats:styled-content style=\"fixed-case\">LNS<\/jats:styled-content> improved select micronutrient status in young non\u2010malnourished <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>onduran children.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ppe.12117","type":"journal-article","created":{"date-parts":[[2014,3,14]],"date-time":"2014-03-14T03:16:59Z","timestamp":1394767019000},"page":"245-254","source":"Crossref","is-referenced-by-count":25,"title":["Effect of Supplementation with a Lipid\u2010Based Nutrient Supplement on the Micronutrient Status of Children Aged 6\u201318 Months Living in the Rural Region of <scp>I<\/scp>ntibuc\u00e1, <scp>H<\/scp>onduras"],"prefix":"10.1111","volume":"28","author":[{"given":"Anna M.","family":"Siega\u2010Riz","sequence":"first","affiliation":[{"name":"Department of Epidemiology Gillings School of Global Public Health University of North Carolina  Chapel Hill NC"},{"name":"Department of Nutrition Gillings School of Global Public Health University of North Carolina  Chapel Hill NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanir\u00e9","family":"Estrada Del Campo","sequence":"additional","affiliation":[{"name":"Department of Nutrition Gillings School of Global Public Health University of North Carolina  Chapel Hill NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan","family":"Kinlaw","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Gillings School of Global Public Health University of North Carolina  Chapel Hill NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory A.","family":"Reinhart","sequence":"additional","affiliation":[{"name":"The Mathile Institute for the Advancement of Human Nutrition  Dayton OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindsay H.","family":"Allen","sequence":"additional","affiliation":[{"name":"ARS Western Human Nutrition Research Center USDA  Davis CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Setareh","family":"Shahab\u2010Ferdows","sequence":"additional","affiliation":[{"name":"ARS Western Human Nutrition Research Center USDA  Davis CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeff","family":"Heck","sequence":"additional","affiliation":[{"name":"Mountain Area Health Education Center University of North Carolina  Asheville NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chirayath M.","family":"Suchindran","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Gillings School of Global Public Health University of North Carolina  Chapel Hill NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret E.","family":"Bentley","sequence":"additional","affiliation":[{"name":"Department of Nutrition Gillings School of Global Public Health University of North Carolina  Chapel Hill NC"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,3,13]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1368980011001315"},{"key":"e_1_2_6_3_1","doi-asserted-by":"crossref","DOI":"10.18356\/00399789-en","volume-title":"Millenium Development Goals Report 2010","author":"United Nations","year":"2010"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1740-8709.2007.00124.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.3945\/jn.107.086199"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mpg.0000235981.26700.d3"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(99)01078-8"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1079\/BJN2000311"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2003.034306"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-200408000-00003"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/87.4.929"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.appet.2009.06.008"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/138.3.593"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.162.7.619"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2008.1018"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0005455"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/88.1.105"},{"key":"e_1_2_6_18_1","unstructured":"Centers for Disease Control and Prevention.Recommendations to prevent and control iron deficiency in the United States. 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