{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T15:54:41Z","timestamp":1757778881595,"version":"3.40.4"},"reference-count":27,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,10,18]],"date-time":"2014-10-18T00:00:00Z","timestamp":1413590400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","award":["R01 DE 11939"],"award-info":[{"award-number":["R01 DE 11939"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32 HD052458"],"award-info":[{"award-number":["T32 HD052458"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Paediatric Perinatal Epid"],"published-print":{"date-parts":[[2014,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Nausea and vomiting during pregnancy (<jats:styled-content style=\"fixed-case\">NVP<\/jats:styled-content>) is the most common complication of pregnancy.<jats:styled-content style=\"fixed-case\">NVP<\/jats:styled-content>has been associated with improved fetal outcomes, but its association with childhood neurodevelopmental outcomes has rarely been studied.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Subjects were children aged 5\u201312 years (<jats:italic>n<\/jats:italic>\u2009=\u2009560) who were controls in a previously conducted case\u2013control study of prenatal risk factors for craniofacial malformations. Information on<jats:styled-content style=\"fixed-case\">NVP<\/jats:styled-content>, including trimester, duration, and treatment, was collected through a maternal interview conducted within 3 years of delivery. Neurocognition was assessed using the<jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>eabody<jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>icture<jats:styled-content style=\"fixed-case\">V<\/jats:styled-content>ocabulary<jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>est (<jats:styled-content style=\"fixed-case\">PPVT\u2010III<\/jats:styled-content>) and the<jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>eery\u2010<jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>uktenica<jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>est of<jats:styled-content style=\"fixed-case\">V<\/jats:styled-content>isual<jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>otor<jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>ntegration\u2010Fifth Edition (<jats:styled-content style=\"fixed-case\">VMI<\/jats:styled-content>\u20105). Psychosocial outcomes, including internalising and externalising behaviour problems, were measured by maternal report, using the<jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>hild<jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>ehavior<jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>hecklist (<jats:styled-content style=\"fixed-case\">CBCL<\/jats:styled-content>), and teacher report, using the<jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>eacher<jats:styled-content style=\"fixed-case\">R<\/jats:styled-content>eport<jats:styled-content style=\"fixed-case\">F<\/jats:styled-content>orm. Linear regression models were used to calculate adjusted mean (adjMD \u22123.04, 95% confidence interval (CI) \u22125.02, \u22121.06) differences (<jats:styled-content style=\"fixed-case\">adjMD<\/jats:styled-content>) and 95% confidence intervals [<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>] on test scores for children exposed and unexposed to<jats:styled-content style=\"fixed-case\">NVP<\/jats:styled-content>\u2005<jats:italic>in utero<\/jats:italic>. Differences based on trimester, duration, and treatment were assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">NVP<\/jats:styled-content>was reported among 63% of women and was most common in early pregnancy. Children exposed to<jats:styled-content style=\"fixed-case\">NVP<\/jats:styled-content>performed worse on the<jats:styled-content style=\"fixed-case\">VMI<\/jats:styled-content>\u20105 [\u22123.04, 95% CI: \u22125.02, \u22121.06] but exhibited few other differences from unexposed children. Durations of<jats:styled-content style=\"fixed-case\">NVP<\/jats:styled-content>\u22654 months were associated with poorer scores on<jats:styled-content style=\"fixed-case\">PPVT\u2010III<\/jats:styled-content>(<jats:styled-content style=\"fixed-case\">adjMD<\/jats:styled-content>\u22122.52),<jats:styled-content style=\"fixed-case\">VMI<\/jats:styled-content>\u20105 (<jats:styled-content style=\"fixed-case\">adjMD<\/jats:styled-content>\u22125.41), and<jats:styled-content style=\"fixed-case\">CBCL<\/jats:styled-content>[<jats:styled-content style=\"fixed-case\">adjMD<\/jats:styled-content>3.38 (internalising) and<jats:styled-content style=\"fixed-case\">adjMD<\/jats:styled-content>4.19 (externalising)].<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Overall, there were few differences between children exposed and unexposed to<jats:styled-content style=\"fixed-case\">NVP<\/jats:styled-content>.<jats:styled-content style=\"fixed-case\">NVP<\/jats:styled-content>was associated with slightly worse visual motor performance, and prolonged<jats:styled-content style=\"fixed-case\">NVP<\/jats:styled-content>and<jats:styled-content style=\"fixed-case\">NVP<\/jats:styled-content>extending late into pregnancy were associated with poorer scores on several neurodevelopmental measures.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ppe.12151","type":"journal-article","created":{"date-parts":[[2014,10,18]],"date-time":"2014-10-18T12:28:10Z","timestamp":1413635290000},"page":"527-535","source":"Crossref","is-referenced-by-count":7,"title":["Nausea and Vomiting during Pregnancy and Neurodevelopmental Outcomes in Offspring"],"prefix":"10.1111","volume":"28","author":[{"given":"Samantha E.","family":"Parker","sequence":"first","affiliation":[{"name":"Slone Epidemiology Center Boston University Boston MA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacqueline 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