{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T14:12:34Z","timestamp":1756995154969},"reference-count":15,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,2,16]],"date-time":"2015-02-16T00:00:00Z","timestamp":1424044800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Paediatric Perinatal Epid"],"published-print":{"date-parts":[[2015,3]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Decades of research has yielded few clues about causes of sudden infant death syndrome (SIDS<\/jats:styled-content>). While some studies have shown a link to inborn errors of metabolism (IEMs<\/jats:styled-content>), few have examined the link in a large population\u2010based sample. This population\u2010based case\u2013control study assessed the association between undiagnosed IEMs<\/jats:styled-content> and SIDS<\/jats:styled-content>.<\/jats:p><\/jats:sec>Methods<\/jats:title>Children born in C<\/jats:styled-content>alifornia during 2005\u201308 who died from SIDS<\/jats:styled-content> were obtained from death records and linked to the newborn screening, birth certificate, and hospital discharge databases. Individuals with known chromosomal and neural tube defects, genetic disorders, and non\u2010singleton births were excluded. Five controls were matched to each case on tandem mass spectrometry testing date and lab code. Rates of undiagnosed IEMs<\/jats:styled-content> were compared between cases and controls using conditional logistic regression adjusting for known confounding factors.<\/jats:p><\/jats:sec>Results<\/jats:title>After adjusting for known confounding factors, SIDS<\/jats:styled-content> cases had similar risk of having IEMs<\/jats:styled-content> as controls (adjusted hazard ratio [HR<\/jats:styled-content>] 1.3, 95% confidence interval [CI<\/jats:styled-content>] 0.3, 5.5). Infants who were male, B<\/jats:styled-content>lack, and born preterm had higher risk of SIDS<\/jats:styled-content> with the highest risk observed for those born preterm [adjusted HR<\/jats:styled-content>\u2009=\u20091.7, 95% CI<\/jats:styled-content> 1.3, 2.2]. Younger maternal age at delivery, mother being born in the US<\/jats:styled-content>, parity after current birth >3, and delayed prenatal care were also significantly associated with higher risk of SIDS<\/jats:styled-content>.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>While many maternal and infant factors are associated with an increased risk of SIDS<\/jats:styled-content>, there is no evidence that undiagnosed IEMs<\/jats:styled-content> are associated with increased risk.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ppe.12175","type":"journal-article","created":{"date-parts":[[2015,2,16]],"date-time":"2015-02-16T10:15:10Z","timestamp":1424081710000},"page":"151-155","source":"Crossref","is-referenced-by-count":8,"title":["Undiagnosed Metabolic Dysfunction and Sudden Infant Death Syndrome \u2013 A Case\u2010Control Study"],"prefix":"10.1111","volume":"29","author":[{"given":"Ning An","family":"Rosenthal","sequence":"first","affiliation":[{"name":"Genetic Disease Screening Program California Department of Public Health Richmond"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert J.","family":"Currier","sequence":"additional","affiliation":[{"name":"Genetic Disease Screening Program California Department of Public Health Richmond"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebecca J.","family":"Baer","sequence":"additional","affiliation":[{"name":"Genetic Disease Screening Program California Department of Public Health Richmond"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa","family":"Feuchtbaum","sequence":"additional","affiliation":[{"name":"Genetic Disease Screening Program California Department of Public Health Richmond"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura L.","family":"Jelliffe\u2010Pawlowski","sequence":"additional","affiliation":[{"name":"Genetic Disease Screening Program California Department of Public Health Richmond"},{"name":"Department of Epidemiology and Biostatistics Division of Preventive Medicine and Public Health University of California San Francisco School of Medicine San Francisco CA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,2,16]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"Centers for Disease Control and Prevention.Sudden Unexpected Infant Death (SUID).http:\/\/www.cdc.gov\/sids\/[last accessed December 2013]."},{"key":"e_1_2_6_3_1","first-page":"1","article-title":"Deaths: leading causes for 2008","volume":"60","author":"Heron M","year":"2012","journal-title":"National Vital Statistics Reports: From the Centers for Disease Control and Prevention, National Center for Health Statistics, National Vital Statistics System"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1542\/pir.33-7-314"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2004-2828"},{"key":"e_1_2_6_6_1","first-page":"677","article-title":"Contribution of selected metabolic diseases to early childhood deaths \u2013 Virginia, 1996\u20132001","volume":"52","author":"Centers for Disease Control and Prevention","year":"2003","journal-title":"MMWR. 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