{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T15:49:02Z","timestamp":1772293742362,"version":"3.50.1"},"reference-count":14,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,2,14]],"date-time":"2015-02-14T00:00:00Z","timestamp":1423872000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Paediatric Perinatal Epid"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Recruitment into large, preconception randomised clinical trials (<jats:styled-content style=\"fixed-case\">RCT<\/jats:styled-content>) is challenging. We describe clinic and community\u2010based preconception recruitment strategies for the <jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>ffects of <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>spirin in <jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>estation and <jats:styled-content style=\"fixed-case\">R<\/jats:styled-content>eproduction (<jats:styled-content style=\"fixed-case\">EAGeR<\/jats:styled-content>) trial and highlight approaches that were and were not successful. This longitudinal <jats:styled-content style=\"fixed-case\">RCT<\/jats:styled-content> was conducted at four major sites in the <jats:styled-content style=\"fixed-case\">US<\/jats:styled-content>. Eligible women had one to two prior pregnancy losses and were actively trying to become pregnant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Provider\/clinic and community\u2010based outreach strategies were utilised, and the recruitment rate and costs of methods were assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A screening questionnaire was completed by 5485 women; 42.4% (<jats:italic>n<\/jats:italic>\u2009=\u20092323) screened were initially eligible, of whom 50.7% (<jats:italic>n<\/jats:italic>\u2009=\u20091228) were randomised. Provider\/clinic\u2010based recruitment yielded the highest number eligible of those screened (30.1%) and also the most randomised participants overall (40.3%). The next highest yield came from direct mail and brochures\/flyers at 13.1% and 12.5% of women randomised, respectively. However, direct mailings cost $720 per participant randomised. Other than word of mouth, provider\/clinic\u2010based recruitment was the most cost effective method, costing an average of $60 per randomised participant. Web\u2010based recruitment yielded 4.7% of participants at a cost of $278 per randomised participant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Provider and clinic\u2010based recruitment was the most effective and cost\u2010efficient method of recruitment in a preconception intervention study of reproduction among women.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ppe.12177","type":"journal-article","created":{"date-parts":[[2015,2,14]],"date-time":"2015-02-14T06:03:15Z","timestamp":1423893795000},"page":"162-167","source":"Crossref","is-referenced-by-count":8,"title":["Recruitment for Longitudinal, Randomised Pregnancy Trials Initiated Preconception: Lessons from the <scp>E<\/scp>ffects of <scp>A<\/scp>spirin in <scp>G<\/scp>estation and <scp>R<\/scp>eproduction <scp>T<\/scp>rial"],"prefix":"10.1111","volume":"29","author":[{"given":"Laurie L.","family":"Lesher","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology University of Utah  Salt Lake City UT"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebecca A.","family":"Matyas","sequence":"additional","affiliation":[{"name":"Epidemiology Branch Division of Intramural Population Health Research Eunice Kennedy Shriver National Institute of Child Health and Human Development  Bethesda MD"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lindsey A.","family":"Sjaarda","sequence":"additional","affiliation":[{"name":"Epidemiology Branch Division of Intramural Population Health Research Eunice Kennedy Shriver National Institute of Child Health and Human Development  Bethesda MD"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah L.","family":"Newman","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University of Utah  Salt Lake City UT"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert M.","family":"Silver","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University of Utah  Salt Lake City UT"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noya","family":"Galai","sequence":"additional","affiliation":[{"name":"Department of Statistics University of Haifa  Haifa Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathleen M.","family":"Hovey","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Environmental Health University at Buffalo, State University of New York  Buffalo NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean","family":"Wactawski\u2010Wende","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Environmental Health University at Buffalo, State University of New York  Buffalo NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leah","family":"Emerick","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University of Colorado  Denver CO"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne M.","family":"Lynch","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University of Colorado  Denver CO"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Betsy","family":"Mead","sequence":"additional","affiliation":[{"name":"Department of Family, Community and Rural Health Commonwealth Medical College  Scranton PA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janet M.","family":"Townsend","sequence":"additional","affiliation":[{"name":"Department of Family, Community and Rural Health Commonwealth Medical College  Scranton PA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neil J.","family":"Perkins","sequence":"additional","affiliation":[{"name":"Epidemiology Branch Division of Intramural Population Health Research Eunice Kennedy Shriver National Institute of Child Health and Human Development  Bethesda MD"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sunni L.","family":"Mumford","sequence":"additional","affiliation":[{"name":"Epidemiology Branch Division of Intramural Population Health Research Eunice Kennedy Shriver National Institute of Child Health and Human Development  Bethesda MD"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph","family":"Stanford","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University of Utah  Salt Lake City UT"},{"name":"Department of Family and Preventive Medicine University of Utah  Salt Lake City UT"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enrique F.","family":"Schisterman","sequence":"additional","affiliation":[{"name":"Epidemiology Branch Division of Intramural Population Health Research Eunice Kennedy Shriver National Institute of Child Health and Human Development  Bethesda MD"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,2,14]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0908056"},{"key":"e_1_2_7_3_1","first-page":"294","article-title":"Embryonic death in early pregnancy: a new look at the first trimester","volume":"84","author":"Goldstein SR","year":"1994","journal-title":"Obstetrics and Gynecology"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2458-7-233"},{"key":"e_1_2_7_5_1","article-title":"Intended and unintended births in the United States: 1982\u20132010","author":"Mosher WD","year":"2012","journal-title":"National Health Statistics Reports"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3016.2011.01205.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)60157-4"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/ppe.12088"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-010-9431-y"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3016.2006.00771.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)48862-X"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198807283190401"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cct.2010.08.001"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3016.2003.00546.x"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.2013.301706"}],"container-title":["Paediatric and Perinatal Epidemiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fppe.12177","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ppe.12177","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T17:20:49Z","timestamp":1696008049000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ppe.12177"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,2,14]]},"references-count":14,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015,3]]}},"alternative-id":["10.1111\/ppe.12177"],"URL":"https:\/\/doi.org\/10.1111\/ppe.12177","archive":["Portico"],"relation":{},"ISSN":["0269-5022","1365-3016"],"issn-type":[{"value":"0269-5022","type":"print"},{"value":"1365-3016","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,2,14]]}}}