{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:32:19Z","timestamp":1790728339810,"version":"4.1.0"},"reference-count":28,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,3,11]],"date-time":"2015-03-11T00:00:00Z","timestamp":1426032000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32 HD052458"],"award-info":[{"award-number":["T32 HD052458"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Paediatric Perinatal Epid"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Pre\u2010eclampsia and placental abruption may share a common pathophysiologic mechanism, namely, uteroplacental ischaemia. The aim of this study was to investigate the association between placental abruption and risk of pre\u2010eclampsia in a subsequent pregnancy, and to determine whether the association differs by the gestational age at the time of abruption.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A nested case\u2013control study among multiparous women in the <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>edical <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>irth <jats:styled-content style=\"fixed-case\">R<\/jats:styled-content>egister of <jats:styled-content style=\"fixed-case\">F<\/jats:styled-content>inland from 1996\u20132010 was conducted. Cases of pre\u2010eclampsia (<jats:italic>n<\/jats:italic>\u2009=\u20096487) and frequency matched controls (<jats:italic>n<\/jats:italic>\u2009=\u200925\u2009948) were linked to the <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>ospital <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>ischarge <jats:styled-content style=\"fixed-case\">R<\/jats:styled-content>egistry to ascertain data on prior abruption. Abruption was categorised as preterm (&lt;37 weeks) or term (\u226537 weeks) based on the gestational age at delivery. We fit logistic regression models to evaluate the associations between abruption and the odds of pre\u2010eclampsia in the subsequent pregnancy before and after adjusting for potential confounders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Preterm abruption was associated with over a twofold increase in risk of pre\u2010eclampsia [odds ratio (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>) 2.2, 95% confidence interval (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>) 1.5, 3.3] in a subsequent pregnancy. In contrast, term abruption was not associated with pre\u2010eclampsia (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 1.1, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.7, 1.7). The association between preterm abruption and pre\u2010eclampsia was further elevated among women with a history of pre\u2010eclampsia. Associations with preterm abruption were also strengthened when the outcome was pre\u2010eclampsia with early delivery (&lt;34 weeks).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These findings suggest that placental abruption in a prior pregnancy is associated with a different risk profile of pre\u2010eclampsia based on the gestational age of the abruption\u2010affected pregnancy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ppe.12184","type":"journal-article","created":{"date-parts":[[2015,3,12]],"date-time":"2015-03-12T00:37:06Z","timestamp":1426120626000},"page":"211-219","source":"Crossref","is-referenced-by-count":30,"title":["Placental Abruption and Subsequent Risk of Pre\u2010eclampsia: A Population\u2010Based Case\u2013Control Study"],"prefix":"10.1111","volume":"29","author":[{"given":"Samantha E.","family":"Parker","sequence":"first","affiliation":[{"name":"Department of Epidemiology Boston University School of Public Health  Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martha M.","family":"Werler","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Boston University School of Public Health  Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mika","family":"Gissler","sequence":"additional","affiliation":[{"name":"National Institute of Health and Welfare (THL) Helsinki, Finland"},{"name":"NHV Nordic School of Public Health  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minna","family":"Tikkanen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Helsinki University Central Hospital University of Helsinki  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cande V.","family":"Ananth","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology College of Physicians and Surgeons, Columbia University, New York, NY"},{"name":"Department of Epidemiology Mailman School of Public Health Columbia University  New York 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