{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T02:52:48Z","timestamp":1785207168572,"version":"3.55.0"},"reference-count":40,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,4,5]],"date-time":"2015-04-05T00:00:00Z","timestamp":1428192000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["MAH-115445"],"award-info":[{"award-number":["MAH-115445"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Paediatric Perinatal Epid"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Rates of postpartum haemorrhage and atonic postpartum haemorrhage have increased in several high\u2010income countries. We carried out a study to examine if drug use in pregnancy, or drug and other interactions, explained this increase in postpartum haemorrhage.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The linked administrative and hospital databases of the<jats:styled-content style=\"fixed-case\">Q<\/jats:styled-content>u\u00e9bec<jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>regnancy<jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>ohort were used to define a cohort of pregnant women in<jats:styled-content style=\"fixed-case\">Q<\/jats:styled-content>u\u00e9bec,<jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>anada, from 1998 to 2009 (<jats:italic>n<\/jats:italic>\u2009=\u2009138\u2009704). Case\u2013control studies on any postpartum haemorrhage and atonic postpartum haemorrhage were carried out within this population, with up to five controls randomly selected for each case after matching on index date and hospital of delivery (incidence density sampling). Conditional logistic regression was used to estimate the effects of drug use on postpartum haemorrhage and atonic postpartum haemorrhage.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was an unexpected non\u2010linear, declining temporal pattern in postpartum haemorrhage and atonic postpartum haemorrhage between 1998 and 2009. Use of antidepressants (mainly selective serotonin reuptake inhibitors) was associated with higher rates of postpartum haemorrhage [adjusted rate ratio (<jats:styled-content style=\"fixed-case\">aRR<\/jats:styled-content>) 1.48, 95% confidence interval (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>) 1.23, 1.77] and atonic postpartum haemorrhage [<jats:styled-content style=\"fixed-case\">aRR<\/jats:styled-content>1.40, 95%<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>1.13, 1.74]. Thrombocytopenia was also associated with higher rates of postpartum haemorrhage [<jats:styled-content style=\"fixed-case\">aRR<\/jats:styled-content>1.52, 95%<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>1.16, 2.00]. There were no statistically significant drug interactions. Adjustment for maternal factors and drug use had little effect on temporal trends in postpartum haemorrhage and atonic postpartum haemorrhage.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Although antidepressant use and thrombocytopenia were associated with higher rates of atonic postpartum haemorrhage, antidepressant and other drug use did not explain temporal trends in postpartum haemorrhage.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ppe.12190","type":"journal-article","created":{"date-parts":[[2015,4,6]],"date-time":"2015-04-06T03:10:50Z","timestamp":1428289850000},"page":"220-231","source":"Crossref","is-referenced-by-count":16,"title":["Can Drug Effects Explain the Recent Temporal Increase in Atonic Postpartum Haemorrhage?"],"prefix":"10.1111","volume":"29","author":[{"given":"K. S.","family":"Joseph","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynaecology School of Population and Public Health Children's and Women's Hospital and Health Centre of British Columbia University of British Columbia Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Odile","family":"Sheehy","sequence":"additional","affiliation":[{"name":"Research Unit on Medications and Pregnancy Centre hospitalier universitaire Saint Justine Research Centre Faculty of Pharmacy University of Montreal Qu\u00e9bec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azar","family":"Mehrabadi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology School of Population and Public Health Children's and Women's Hospital and Health Centre of British Columbia University of British Columbia Vancouver British Columbia 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