{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T06:39:48Z","timestamp":1767854388604,"version":"3.49.0"},"reference-count":40,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,5,19]],"date-time":"2015-05-19T00:00:00Z","timestamp":1431993600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004737","name":"National Health Research Institutes","doi-asserted-by":"crossref","award":["NP-103-SP02"],"award-info":[{"award-number":["NP-103-SP02"]}],"id":[{"id":"10.13039\/501100004737","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Paediatric Perinatal Epid"],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Infection in pregnancy has long been linked with negative postnatal development and health. This study aims to assess the association between prenatal infections and autism spectrum disorders (<jats:styled-content style=\"fixed-case\">ASDs<\/jats:styled-content>) across three trimesters and to probe possible sex heterogeneity in such link.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>A total of 4184 children with incident <jats:styled-content style=\"fixed-case\">ASDs<\/jats:styled-content> and 16\u2009734 matched children were identified from the 2000\u20132007 <jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>ational <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>ealth <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>nsurance <jats:styled-content style=\"fixed-case\">R<\/jats:styled-content>esearch <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>atabase. For each child, information pertaining to the mother's infection during pregnancy, sociodemographics, and medical history was retrieved from healthcare records. Conditional logistic analyses were carried out to estimate the strength of associations with adjustment for multiple comparisons.<\/jats:p><\/jats:sec><jats:sec><jats:title>Result<\/jats:title><jats:p>Pooled analyses demonstrated that having two or more outpatient visits for genital infection [adjusted odds ratio (<jats:styled-content style=\"fixed-case\">aOR<\/jats:styled-content>): 1.34; 95% confidence interval (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>) 1.12, 1.60; false discovery rate (<jats:styled-content style=\"fixed-case\">FDR<\/jats:styled-content>)\u2009&lt;\u20090.01] and bacterial infection (<jats:styled-content style=\"fixed-case\">aOR<\/jats:styled-content>: 1.24; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.06, 1.43; <jats:styled-content style=\"fixed-case\">FDR<\/jats:styled-content>\u2009&lt;\u20090.05) in the third trimester were slightly associated with increased risk of <jats:styled-content style=\"fixed-case\">ASDs<\/jats:styled-content>. No statistically significant sex differences were found.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The present study contributes updated population\u2010based evidence about the connection between prenatal infection and <jats:styled-content style=\"fixed-case\">ASDs<\/jats:styled-content>. Potential effect of bacterial and genital tract infections during the third trimester on risk of <jats:styled-content style=\"fixed-case\">ASDs<\/jats:styled-content> warrants further exploration.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ppe.12194","type":"journal-article","created":{"date-parts":[[2015,5,19]],"date-time":"2015-05-19T17:24:49Z","timestamp":1432056289000},"page":"307-316","source":"Crossref","is-referenced-by-count":59,"title":["Prenatal Infection and Autism Spectrum Disorders in Childhood: A Population\u2010Based Case\u2013Control Study in <scp>T<\/scp>aiwan"],"prefix":"10.1111","volume":"29","author":[{"given":"Shao\u2010You","family":"Fang","sequence":"first","affiliation":[{"name":"Institute of Public Health National Yang\u2010Ming University  Taipei Taiwan"},{"name":"Center of Neuropsychiatric Research National Health Research Institutes  Miaoli County 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