{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T09:42:10Z","timestamp":1790242930021,"version":"4.1.0"},"reference-count":35,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,6,25]],"date-time":"2015-06-25T00:00:00Z","timestamp":1435190400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000071","name":"National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["HHSN275201200005C, HHSN267200700019C"],"award-info":[{"award-number":["HHSN275201200005C, HHSN267200700019C"]}],"id":[{"id":"10.13039\/100000071","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Paediatric Perinatal Epid"],"published-print":{"date-parts":[[2015,7]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Adipokines can serve as a measure of adipose tissue activity. Although birthweight correlates with neonatal adiposity, findings for cord blood levels of adipokines and birth outcomes have been conflicted. Therefore, we determined the cross\u2010sectional associations between adipokines measured in newborn dried blood spots (DBS<\/jats:styled-content>) and birth outcomes.<\/jats:p><\/jats:sec>Methods<\/jats:title>The Upstate KIDS<\/jats:styled-content> study enrolled mothers and infants from 2008 to 2010. Among infants whose parents consented to the use of residual DBS<\/jats:styled-content> from newborn screening, 2397 singletons and 1240 twins had adipokine measurements from the H<\/jats:styled-content>uman O<\/jats:styled-content>besity P<\/jats:styled-content>anel (R<\/jats:styled-content>&D S<\/jats:styled-content>ystems) by L<\/jats:styled-content>uminex. Odds ratios were estimated by multivariable logistic regression for risk of birth outcomes of preterm delivery (<37 weeks for singletons, <32 for twins) and small\u2010for\u2010gestational age (SGA<\/jats:styled-content> <10th for singletons and <3rd for twins age\u2010 and sex\u2010specific percentiles) by adipokine quintiles. Generalised estimating equations were applied to account for correlations between twins.<\/jats:p><\/jats:sec>Results<\/jats:title>Singletons in the lowest compared with the highest quintile of adiponectin were more likely preterm (adjusted odds ratio 3.26; 95% confidence interval [CI] 1.99, 5.34) and SGA<\/jats:styled-content> (1.81; [95% CI 1.18, 2.77]). Similar associations were observed among twins. Resistin was associated with preterm birth (Q<\/jats:styled-content>1 vs. Q<\/jats:styled-content>5: 2.08; [95% CI 1.20, 3.62]) only among singletons. Adipsin had inconsistent associations after adjustment.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>This large population\u2010based study demonstrates that newborn DBS<\/jats:styled-content>\u2010measured adipokines are associated with birth outcomes, particularly preterm birth and SGA<\/jats:styled-content> among those with lower adiponectin levels regardless of plurality.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ppe.12203","type":"journal-article","created":{"date-parts":[[2015,6,27]],"date-time":"2015-06-27T02:17:12Z","timestamp":1435371432000},"page":"317-325","source":"Crossref","is-referenced-by-count":36,"title":["Newborn Adipokines and Birth Outcomes"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3851-2613","authenticated-orcid":false,"given":"Edwina H.","family":"Yeung","sequence":"first","affiliation":[{"name":"Epidemiology Branch Division of Intramural Population Health Research Eunice Kennedy Shriver National Institute of Child Health and Human Development Bethesda MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander C.","family":"McLain","sequence":"additional","affiliation":[{"name":"Epidemiology Branch Division of Intramural Population Health Research Eunice Kennedy Shriver National Institute of Child Health and Human Development Bethesda MD"},{"name":"Department of Epidemiology and Biostatistics Arnold School of Public Health Columbia SC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy","family":"Anderson","sequence":"additional","affiliation":[{"name":"Laboratory of Immunology Wadsworth Center Center for Medical Science Albany NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Lawrence","sequence":"additional","affiliation":[{"name":"Laboratory of Immunology Wadsworth Center Center for Medical Science Albany NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nansi S.","family":"Boghossian","sequence":"additional","affiliation":[{"name":"Epidemiology Branch Division of Intramural Population Health Research Eunice Kennedy Shriver National Institute of Child Health and Human Development Bethesda MD"},{"name":"Department of Epidemiology and Biostatistics Arnold School of Public Health Columbia SC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"Druschel","sequence":"additional","affiliation":[{"name":"Bureau of Environmental and Occupational Epidemiology Center for Environmental Health New York State Department of Health Albany NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin","family":"Bell","sequence":"additional","affiliation":[{"name":"Department of Environmental Health Sciences University at Albany School of Public Health Albany NY"},{"name":"Department of Epidemiology and Biostatistics University at Albany School of Public Health Albany 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