{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T07:38:22Z","timestamp":1773041902806,"version":"3.50.1"},"reference-count":43,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,7,14]],"date-time":"2015-07-14T00:00:00Z","timestamp":1436832000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Paediatric Perinatal Epid"],"published-print":{"date-parts":[[2015,9]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Despite the putative intrauterine origins of childhood (0\u201314 years) leukaemia, it is complex to assess the impact of perinatal factors on disease onset. Results on the association of maternal history of fetal loss (miscarriage\/stillbirth) with specific disease subtypes in the subsequent offspring are in conflict. We sought to investigate whether miscarriage and stillbirth may have different impacts on the risk of acute lymphoblastic leukaemia (ALL<\/jats:styled-content>) and of its main immunophenotypes (B<\/jats:styled-content>\u2010cell and T<\/jats:styled-content>\u2010cell ALL<\/jats:styled-content>), as contrasted to acute myeloid leukaemia (AML<\/jats:styled-content>).<\/jats:p><\/jats:sec>Methods<\/jats:title>One thousand ninety\u2010nine ALL<\/jats:styled-content> incidents (957 B<\/jats:styled-content>\u2010ALL<\/jats:styled-content>) and 131 AML<\/jats:styled-content> cases along with 1:1 age and gender\u2010matched controls derived from the N<\/jats:styled-content>ationwide R<\/jats:styled-content>egistry for C<\/jats:styled-content>hildhood H<\/jats:styled-content>ematological M<\/jats:styled-content>alignancies and B<\/jats:styled-content>rain T<\/jats:styled-content>umors (1996\u20132013) were studied. Multivariable regression models were used to assess the roles of previous miscarriage(s) and stillbirth(s) on ALL<\/jats:styled-content> (overall, B<\/jats:styled-content>\u2010, T<\/jats:styled-content>\u2010ALL<\/jats:styled-content>) and AML<\/jats:styled-content>, controlling for potential confounders.<\/jats:p><\/jats:sec>Results<\/jats:title>Statistically significant exposure and disease subtype\u2010specific associations of previous miscarriage(s) exclusively with AML<\/jats:styled-content> [odds ratio (OR<\/jats:styled-content>) 1.67, 95% confidence interval (CI<\/jats:styled-content>) 1.00, 2.81] and stillbirth(s) with ALL<\/jats:styled-content> [OR<\/jats:styled-content> 4.82, 95% CI<\/jats:styled-content> 1.63, 14.24] and B<\/jats:styled-content>\u2010ALL<\/jats:styled-content> particularly, emerged.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Differential pathophysiological pathways pertaining to genetic polymorphisms or cytogenetic aberrations are likely to create hostile environments leading either to fetal loss or the development of specific leukaemia subtypes in subsequent offspring, notably distinct associations of maternal miscarriage history confined to AML<\/jats:styled-content> and stillbirth history confined to ALL<\/jats:styled-content> (specifically B<\/jats:styled-content>\u2010ALL<\/jats:styled-content>). If confirmed and further supported by studies revealing underlying mechanisms, these results may shed light on the divergent leukemogenesis processes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ppe.12207","type":"journal-article","created":{"date-parts":[[2015,7,14]],"date-time":"2015-07-14T21:44:48Z","timestamp":1436910288000},"page":"453-461","source":"Crossref","is-referenced-by-count":6,"title":["History of Maternal Fetal Loss and Childhood Leukaemia Risk in Subsequent Offspring: Differentials by Miscarriage or Stillbirth History and Disease Subtype"],"prefix":"10.1111","volume":"29","author":[{"given":"M. A.","family":"Karalexi","sequence":"first","affiliation":[{"name":"Department of Hygiene, Epidemiology and Medical Statistics School of Medicine University of Athens Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Skalkidou","sequence":"additional","affiliation":[{"name":"Department of Women's and Children's Health Uppsala University Uppsala Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T. P.","family":"Thomopoulos","sequence":"additional","affiliation":[{"name":"Department of Hygiene, Epidemiology and Medical Statistics School of Medicine University of Athens Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Belechri","sequence":"additional","affiliation":[{"name":"Department of Hygiene, Epidemiology and Medical Statistics School of Medicine University of Athens Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.\u2010I.","family":"Biniaris\u2010Georgallis","sequence":"additional","affiliation":[{"name":"Department of Hygiene, Epidemiology and Medical Statistics School of Medicine University of Athens Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Bouka","sequence":"additional","affiliation":[{"name":"Department of Hygiene, Epidemiology and Medical Statistics School of Medicine University of Athens Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Baka","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology\u2010Oncology \u2018Pan. & Agl. Kyriakou\u2019 Children's Hospital Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Hatzipantelis","sequence":"additional","affiliation":[{"name":"2nd Department of Pediatrics Aristotelion University of Thessaloniki AHEPA General Hospital Thessaloniki Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Kourti","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology and Oncology Hippokration Hospital Thessaloniki Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Polychronopoulou","sequence":"additional","affiliation":[{"name":"Department of Pediatric Haematology\u2010Oncology \u2018Aghia Sophia\u2019 Children's Hospital Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Sidi","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology and Oncology Hippokration Hospital Thessaloniki Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Stiakaki","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology\u2010Oncology University Hospital of Heraklion Heraklion Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Moschovi","sequence":"additional","affiliation":[{"name":"Haematology\u2010Oncology Unit First Department of Pediatrics Athens University Medical School \u2018Aghia Sophia\u2019 Children's Hospital Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Dessypris","sequence":"additional","affiliation":[{"name":"Department of Hygiene, Epidemiology and Medical Statistics School of Medicine University of Athens Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. 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