{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T13:10:21Z","timestamp":1772802621044,"version":"3.50.1"},"reference-count":35,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,10,19]],"date-time":"2015-10-19T00:00:00Z","timestamp":1445212800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Western Norway Regional Health Authority","award":["911764"],"award-info":[{"award-number":["911764"]}]},{"name":"Research Council Norway","award":["190858\/V50"],"award-info":[{"award-number":["190858\/V50"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Paediatric Perinatal Epid"],"published-print":{"date-parts":[[2016,1]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>The aetiology of congenital heart defects (CHD<\/jats:styled-content>) is mostly unknown, but maternal factors may modify the infant risk of CHD<\/jats:styled-content>. We investigated the association between maternal preeclampsia and offspring risk of severe CHD<\/jats:styled-content> in a nation\u2010wide cohort study.<\/jats:p><\/jats:sec>Methods<\/jats:title>Information on all births registered in the M<\/jats:styled-content>edical B<\/jats:styled-content>irth R<\/jats:styled-content>egistry of N<\/jats:styled-content>orway, 1994\u20132009, was completed with information on CHD<\/jats:styled-content> diagnoses from national health registries and the C<\/jats:styled-content>ardiovascular D<\/jats:styled-content>iseases in N<\/jats:styled-content>orway P<\/jats:styled-content>roject (CVDNOR<\/jats:styled-content>).<\/jats:p><\/jats:sec>Results<\/jats:title>Among 914\u2009703 singleton births without chromosomal abnormalities, 32\u2009864 (3.6%) were born after a pregnancy with preeclampsia. The preeclampsia was diagnosed before the 34th week of pregnancy (early\u2010onset preeclampsia) in 2618 (8.0% of preeclamptic pregnancies). CHD<\/jats:styled-content>s were diagnosed in 10\u2009691 infants; of these, 2473 had severe CHD<\/jats:styled-content>. The risk of severe CHD<\/jats:styled-content> was compared between births with and without maternal preeclampsia and estimated with binomial log\u2010linear regression. When adjusting for year of birth, maternal age, parity, and pregestational diabetes, the risk ratio (RR<\/jats:styled-content>) for severe CHD<\/jats:styled-content> in offspring of mothers with any preeclampsia was 1.3 [95% confidence interval (CI<\/jats:styled-content>) 1.1, 1.5], and in pregnancies with early\u2010onset preeclampsia, the RR<\/jats:styled-content> was 2.8 (95% CI<\/jats:styled-content> 1.8, 4.4). The association between early\u2010onset preeclampsia and specific types of severe CHD<\/jats:styled-content> was stronger for atrioventricular septal defects (AVSD<\/jats:styled-content>), with adjusted RR<\/jats:styled-content> 13.5 (95% CI<\/jats:styled-content> 6.8, 26.8).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Early\u2010onset preeclampsia was strongly associated with infant risk of severe CHD<\/jats:styled-content>, specifically; the risk of AVSD<\/jats:styled-content> was 15\u2010fold higher if the mother was diagnosed with early\u2010onset preeclampsia, suggesting common aetiological factors for early\u2010onset preeclampsia and erroneous fetal heart development.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ppe.12252","type":"journal-article","created":{"date-parts":[[2015,10,20]],"date-time":"2015-10-20T11:21:57Z","timestamp":1445340117000},"page":"76-85","source":"Crossref","is-referenced-by-count":66,"title":["Possible Common Aetiology behind Maternal Preeclampsia and Congenital Heart Defects in the Child: a Cardiovascular Diseases in N<\/scp>orway Project Study"],"prefix":"10.1111","volume":"30","author":[{"given":"Kristoffer","family":"Brodwall","sequence":"first","affiliation":[{"name":"Department of Global Public Health and Primary Care University of Bergen Bergen Norway"},{"name":"Department of Paediatrics Haukeland University Hospital Bergen Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4988-1203","authenticated-orcid":false,"given":"Elisabeth","family":"Leirgul","sequence":"additional","affiliation":[{"name":"Department of Global Public Health and Primary Care University of Bergen Bergen Norway"},{"name":"Department of Heart Disease Haukeland University Hospital Bergen Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gottfried","family":"Greve","sequence":"additional","affiliation":[{"name":"Department of Medical Science University of Bergen Bergen Norway"},{"name":"Department of Paediatrics Haukeland University Hospital Bergen Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stein Emil","family":"Vollset","sequence":"additional","affiliation":[{"name":"Department of Global Public Health and Primary Care University of Bergen Bergen Norway"},{"name":"Norwegian Institute of Public Health"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henrik","family":"Holmstr\u00f8m","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Oslo University Hospital Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grethe S.","family":"Tell","sequence":"additional","affiliation":[{"name":"Department of Global Public Health and Primary Care University of Bergen Bergen Norway"},{"name":"Department of Health Registries Norwegian Institute of Public Health Bergen Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nina","family":"\u00d8yen","sequence":"additional","affiliation":[{"name":"Department of Global Public Health and Primary Care University of Bergen Bergen Norway"},{"name":"Center for Medical Genetics and Molecular Medicine Haukeland University Hospital Bergen Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,10,19]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.183216"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.112.001054"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000291497"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2000.tb11582.x"},{"key":"e_1_2_7_6_1","first-page":"1","article-title":"Is preeclampsia associated with fetal malformation? 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