{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T18:43:27Z","timestamp":1781635407254,"version":"3.54.5"},"reference-count":35,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,3,25]],"date-time":"2016-03-25T00:00:00Z","timestamp":1458864000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Department of Anesthesiology, Mayo Clinic, Rochester, Minnesota"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Paediatric Perinatal Epid"],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Outcomes of neonates with congenital diaphragmatic hernia (<jats:styled-content style=\"fixed-case\">CDH<\/jats:styled-content>) are variable; reports are frequently limited to the experience of single tertiary care centres\u2014a possible source of bias. Population\u2010based studies decrease survivor bias and provide additional insight into this high\u2010mortality condition. The objective of this study was to examine the incidence and outcomes of <jats:styled-content style=\"fixed-case\">CDH<\/jats:styled-content> in Croatia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>All cases of <jats:styled-content style=\"fixed-case\">CDH<\/jats:styled-content> in Croatia from 2001 through 2013 were ascertained from public health records. Overall and sex\u2010 and region\u2010specific incidence rates were calculated, and characteristics associated with 1\u2010year survival were assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We identified 145 cases of <jats:styled-content style=\"fixed-case\">CDH<\/jats:styled-content> during the study period, for an incidence of 2.67 per 10\u00a0000 total births. The incidence did not differ by calendar year (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a00<\/jats:italic>.38) or geographic region (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a00<\/jats:italic>.67). There was a slightly higher incidence among males (rate ratio, 1.37, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.99, 1.91). The 1\u2010year survival rate was 33.1% for the entire cohort and 47.9% for liveborns who received any treatment at an intensive care unit. From multivariable analysis, survival was decreased in neonates with left <jats:styled-content style=\"fixed-case\">CDH<\/jats:styled-content>, liver up (odds ratio 0.1, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 0.03, 0.4) and increased when treated in a centre with higher case volume (odds ratio 12.8, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 2.2, 72.1).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The incidence of <jats:styled-content style=\"fixed-case\">CDH<\/jats:styled-content> in Croatia is within the range of previous reports. Survival was substantially higher in neonates treated in a centre with higher case volume, which suggests that centralisation of medical care for <jats:styled-content style=\"fixed-case\">CDH<\/jats:styled-content> may be warranted in Croatia.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ppe.12289","type":"journal-article","created":{"date-parts":[[2016,3,26]],"date-time":"2016-03-26T00:06:39Z","timestamp":1458950799000},"page":"336-345","source":"Crossref","is-referenced-by-count":17,"title":["Epidemiology and Outcomes of Congenital Diaphragmatic Hernia in Croatia: A Population\u2010Based Study"],"prefix":"10.1111","volume":"30","author":[{"given":"Ru\u017ea","family":"Grizelj","sequence":"first","affiliation":[{"name":"Department of Pediatrics School of Medicine University of Zagreb University Hospital Centre Zagreb Zagreb Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarina","family":"Bojani\u0107","sequence":"additional","affiliation":[{"name":"Division of Neonatology Department of Obstetrics and Gynecology University Hospital Merkur Zagreb Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jurica","family":"Vukovi\u0107","sequence":"additional","affiliation":[{"name":"Department of Pediatrics School of Medicine University of Zagreb University Hospital Centre Zagreb Zagreb Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milivoj","family":"Novak","sequence":"additional","affiliation":[{"name":"Department of Pediatrics School of Medicine University of Zagreb University Hospital Centre Zagreb Zagreb Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Urelija","family":"Rodin","sequence":"additional","affiliation":[{"name":"School of Public Health \u201cA. \u0160tampar\u201d and Croatian Institute of Public Health School of Medicine University of Zagreb Zagreb Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanja","family":"\u0106ori\u0107","sequence":"additional","affiliation":[{"name":"School of Public Health \u201cA. \u0160tampar\u201d and Croatian Institute of Public Health School of Medicine University of Zagreb Zagreb Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milan","family":"Stanojevi\u0107","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University Hospital Sveti Duh School of Medicine University of Zagreb Zagreb Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darrell R.","family":"Schroeder","sequence":"additional","affiliation":[{"name":"Division of Biomedical Statistics and Informatics Mayo Clinic Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toby N.","family":"Weingarten","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Mayo Clinic Rochester 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