{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T09:22:43Z","timestamp":1761988963349},"reference-count":33,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,5,16]],"date-time":"2016-05-16T00:00:00Z","timestamp":1463356800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001826","name":"ZonMw","doi-asserted-by":"publisher","award":["920\u2010035\u201089"],"award-info":[{"award-number":["920\u2010035\u201089"]}],"id":[{"id":"10.13039\/501100001826","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006483","name":"AbbVie","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006483","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Paediatric Perinatal Epid"],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Recurrent wheezing in young infants has a high prevalence, influences quality of life, and generates substantial health care costs. We previously showed that respiratory syncytial virus infection is an important mechanism of recurrent wheezing in moderate preterm infants. We aimed to provide population\u2010attributable risks (<jats:styled-content style=\"fixed-case\">PAR<\/jats:styled-content>) of risk factors for recurrent wheezing during the first year of life in otherwise healthy moderate preterm infants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">RISK<\/jats:styled-content> is a multicentre prospective birth cohort study of 4424 moderate preterm infants born at 32\u201335 weeks gestation. We estimated <jats:styled-content style=\"fixed-case\">PAR<\/jats:styled-content> of risk factors for recurrent wheezing, which was defined as three or more parent\u2010reported wheezing episodes during the first year of life.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We evaluated 3952 (89%) children at 1 year of age, of whom 705 infants (18%) developed recurrent wheezing. Fourteen variables were independently associated with recurrent wheezing. Hospitalisation for respiratory syncytial virus bronchiolitis had a strong relationship with recurrent wheezing (<jats:styled-content style=\"fixed-case\">RR<\/jats:styled-content> 2.6; 95% confidence interval, <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 2.2, 3.1), but a relative modest <jats:styled-content style=\"fixed-case\">PAR<\/jats:styled-content> (8%; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 6, 11%) which can be explained by a low prevalence (13%). Day\u2010care attendance showed a strong relationship with recurrent wheezing (<jats:styled-content style=\"fixed-case\">RR<\/jats:styled-content> 1.9; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.7, 2.2) and the highest <jats:styled-content style=\"fixed-case\">PAR<\/jats:styled-content> (32%; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 23, 37%) due to a high prevalence (67%). The combined adjusted <jats:styled-content style=\"fixed-case\">PAR<\/jats:styled-content> for the 14 risk factors associated with recurrent wheezing was 49% (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 46, 52%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In moderate preterm infants, day\u2010care attendance has the largest <jats:styled-content style=\"fixed-case\">PAR<\/jats:styled-content> for recurrent wheezing. Trial evidence is needed to determine the potential benefit of delayed day\u2010care attendance in this population.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ppe.12295","type":"journal-article","created":{"date-parts":[[2016,5,21]],"date-time":"2016-05-21T21:17:59Z","timestamp":1463865479000},"page":"376-385","source":"Crossref","is-referenced-by-count":13,"title":["Population\u2010Attributable Risk of Risk Factors for Recurrent Wheezing in Moderate Preterm Infants During the First Year of Life"],"prefix":"10.1111","volume":"30","author":[{"given":"Maarten O.","family":"Blanken","sequence":"first","affiliation":[{"name":"Division of Pediatric Immunology and Infectious Diseases University Medical Center Utrecht Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koos","family":"Korsten","sequence":"additional","affiliation":[{"name":"Division of Pediatric Immunology and Infectious Diseases University Medical Center Utrecht Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niek B.","family":"Achten","sequence":"additional","affiliation":[{"name":"Division of Pediatric Immunology and Infectious Diseases University Medical Center Utrecht Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saskia","family":"Tamminga","sequence":"additional","affiliation":[{"name":"Division of Pediatric Immunology and Infectious Diseases University Medical Center Utrecht Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabeth E.","family":"Nibbelke","sequence":"additional","affiliation":[{"name":"Division of Pediatric Immunology and Infectious Diseases University Medical Center Utrecht Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabeth A.M.","family":"Sanders","sequence":"additional","affiliation":[{"name":"Division of Pediatric Immunology and Infectious Diseases University Medical Center Utrecht Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henriette A.","family":"Smit","sequence":"additional","affiliation":[{"name":"Division Julius Center for Health Sciences and Primary Care University Medical Center Utrecht Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rolf H.H.","family":"Groenwold","sequence":"additional","affiliation":[{"name":"Division Julius Center for Health Sciences and Primary Care University Medical Center Utrecht Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louis","family":"Bont","sequence":"additional","affiliation":[{"name":"Division of Pediatric Immunology and Infectious Diseases University Medical Center Utrecht Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"the Dutch RSV Neonatal 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