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We examined the associations of subcutaneous fat in infancy with total and abdominal fat at school\u2010age.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In a population\u2010based prospective cohort study among 821 children, we calculated total subcutaneous fat (sum of biceps, triceps, suprailiacal, and subscapular skinfold thicknesses) and central\u2010to\u2010total subcutaneous fat ratio (sum of suprailiacal and subscapular skinfold thicknesses\/total subcutaneous fat) at 1.5 and 24 months. At 6 years, we measured fat mass index (total fat\/height<jats:sup>3<\/jats:sup>), central\u2010to\u2010total fat ratio (trunk fat\/total fat), and android\u2010to\u2010gynoid fat ratio (android fat\/gynoid fat) by dual\u2010energy X\u2010ray absorptiometry and preperitoneal fat mass area by abdominal ultrasound.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Central\u2010to\u2010total subcutaneous fat ratio at 1.5 months was positively associated with fat mass index and central\u2010to\u2010total fat ratio at 6 years, whereas both total and central\u2010to\u2010total subcutaneous fat ratio at 24 months were positively associated with all childhood adiposity measures. A 1\u2010standard\u2010deviation scores higher total subcutaneous fat at 24 months was associated with an increased risk of childhood overweight (odds ratio 1.70, 95% confidence interval 1.36, 2.12). These associations were weaker than those for body mass index and stronger among girls than boys.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Subcutaneous fat in infancy is positively associated with total and abdominal fat at school\u2010age. Our results also suggest that skinfold thicknesses add little value to estimate later body fat, as compared with body mass index.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ppe.12307","type":"journal-article","created":{"date-parts":[[2016,5,26]],"date-time":"2016-05-26T13:13:46Z","timestamp":1464268426000},"page":"511-520","source":"Crossref","is-referenced-by-count":24,"title":["Associations of Infant Subcutaneous Fat Mass with Total and Abdominal Fat Mass at School\u2010Age: The Generation R Study"],"prefix":"10.1111","volume":"30","author":[{"given":"Susana","family":"Santos","sequence":"first","affiliation":[{"name":"EPI\u2010Unit Institute of Public Health University of Porto Porto Portugal"},{"name":"The Generation R Study Group Erasmus MC University Medical Center Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romy","family":"Gaillard","sequence":"additional","affiliation":[{"name":"The Generation R Study Group Erasmus MC University Medical Center Rotterdam The Netherlands"},{"name":"Department of Pediatrics Erasmus MC University Medical Center Rotterdam The Netherlands"},{"name":"Department of Epidemiology Erasmus MC University Medical Center Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreia","family":"Oliveira","sequence":"additional","affiliation":[{"name":"EPI\u2010Unit Institute of Public Health University of Porto Porto Portugal"},{"name":"Department of Clinical Epidemiology, Predictive Medicine and Public Health University of Porto Medical School Porto Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrique","family":"Barros","sequence":"additional","affiliation":[{"name":"EPI\u2010Unit Institute of Public Health University of Porto Porto Portugal"},{"name":"Department of Clinical Epidemiology, Predictive Medicine and Public Health University of Porto Medical School Porto Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marieke","family":"Abrahamse\u2010Berkeveld","sequence":"additional","affiliation":[{"name":"Nutricia Research Danone Nutricia Early Life Nutrition Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eline M.","family":"van der Beek","sequence":"additional","affiliation":[{"name":"Nutricia Research Danone Nutricia Early Life Nutrition Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert","family":"Hofman","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Erasmus MC University Medical Center Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent W. 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