{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T01:48:01Z","timestamp":1784684881941,"version":"3.55.0"},"reference-count":42,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,2,20]],"date-time":"2017-02-20T00:00:00Z","timestamp":1487548800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["2014\u20103561"],"award-info":[{"award-number":["2014\u20103561"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004047","name":"Karolinska Institutet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004047","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Paediatric Perinatal Epid"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>There is an established association between adverse events during perinatal life and chronic hypertension in adult life. However, disadvantageous conditions often co\u2010exist in the same pregnancy. We investigated single and joint perinatal exposure to preeclampsia, being born small for gestational age (<jats:styled-content style=\"fixed-case\">SGA<\/jats:styled-content>) or preterm and subsequent risk of chronic hypertension.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study population consisted of 731 008 primiparous women from Norway and Sweden registered in the Medical Birth Registers, both as infants and as first time mothers between 1967\u20132009 (Norway) and 1973\u20132010 (Sweden). Risk of chronic hypertension in early pregnancy was calculated in women with perinatal exposures to preeclampsia, born <jats:styled-content style=\"fixed-case\">SGA<\/jats:styled-content> or preterm by log\u2010binominal regression analysis, and adjusted for maternal age and level of education in the first generation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The rate of chronic hypertension was 0.4%. Risk of chronic hypertension was associated with single perinatal exposure to preeclampsia, being born <jats:styled-content style=\"fixed-case\">SGA<\/jats:styled-content> or preterm with adjusted relative risk (95% confidence interval, <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>) of 2.2 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.8, 2.7), 1.1 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.0, 1.3), and 1.3 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.0, 1.5) respectively. The risks increased after joint exposures, with an almost fourfold risk increase after perinatal exposure to preeclampsia and preterm birth. Additional adjustment for <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content> and smoking in the second generation in a subset of the cohort only had a minor impact on the results.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Perinatal exposure to preeclampsia, being born <jats:styled-content style=\"fixed-case\">SGA<\/jats:styled-content> or preterm is independently associated with increased risk of chronic hypertension. The highest risk was seen after exposure to preeclampsia, especially if combined with <jats:styled-content style=\"fixed-case\">SGA<\/jats:styled-content> or preterm birth.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ppe.12346","type":"journal-article","created":{"date-parts":[[2017,2,20]],"date-time":"2017-02-20T10:48:48Z","timestamp":1487587728000},"page":"89-98","source":"Crossref","is-referenced-by-count":11,"title":["Chronic Hypertension in Women after Perinatal Exposure to Preeclampsia, Being Born Small for Gestational Age or Preterm"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4427-1075","authenticated-orcid":false,"given":"Linda","family":"Lindstr\u00f6m","sequence":"first","affiliation":[{"name":"Department of Women's and Children's Health Uppsala University Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rolv","family":"Skj\u00e6rven","sequence":"additional","affiliation":[{"name":"Department of Global Public Health and Primary Care Medical Birth Registry of Norway Norwegian Institute of Public Health University of Bergen Bergen Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Bergman","sequence":"additional","affiliation":[{"name":"Department of Women's and Children's Health Uppsala University Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Lundgren","sequence":"additional","affiliation":[{"name":"Department of Women's and Children's Health Uppsala University Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kari","family":"Klungs\u00f8yr","sequence":"additional","affiliation":[{"name":"Department of Global Public Health and Primary Care Medical Birth Registry of Norway Norwegian Institute of Public Health University of Bergen Bergen Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0805-8093","authenticated-orcid":false,"given":"Sven","family":"Cnattingius","sequence":"additional","affiliation":[{"name":"Clinical Epidemiology Unit Department of Medicine Solna Karolinska Institutet Karolinska University Hospital Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna\u2010Karin","family":"Wikstr\u00f6m","sequence":"additional","affiliation":[{"name":"Department of Women's and Children's Health Uppsala University Uppsala Sweden"},{"name":"Clinical Epidemiology Unit Department of Medicine Solna Karolinska Institutet Karolinska University Hospital Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,2,20]]},"reference":[{"key":"e_1_2_6_2_1","volume-title":"A Global Brief on Hypertension: Silent Killer, Global Public Health Crisis","author":"World Health Organization","year":"2013"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.107.090480"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.111.034884"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.39335.385301.BE"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)05112-6"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0b013e328331b8c6"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.111.181784"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/GRF.0b013e31829cb9ca"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1472-6483(10)60649-9"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.311.7008.773"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.acvd.2011.10.006"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.36.5.790"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ede.0000172134.45742.49"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0000000000000612"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)60484-9"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1996.tb14164.x"},{"key":"e_1_2_6_18_1","volume-title":"Hypertension in Pregnancy: the Management of Hypertensive Disorders During Pregnancy. 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