{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:20:35Z","timestamp":1787016035477,"version":"build-2736575974"},"reference-count":39,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,2,21]],"date-time":"2017-02-21T00:00:00Z","timestamp":1487635200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Department of Public Health, University of Copenhagen, Copenhagen, Denmark"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Paediatric Perinatal Epid"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Cardiovascular (\n                      <jats:styled-content style=\"fixed-case\">CVD<\/jats:styled-content>\n                      ) complications stemming from vascular dysfunction have been widely explored in the setting of preeclampsia. However, the impact of abruption, a strong indicator of microvascular disturbance, on the risk of\n                      <jats:styled-content style=\"fixed-case\">CVD<\/jats:styled-content>\n                      mortality and morbidity remains poorly characterised.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We designed a cohort analysis of 828\u00a0289 women who delivered singletons in Denmark between 1978 and 2010. We linked the National Patient Registry and the Registry of Causes of Death to the Danish Birth Registry to ascertain\n                      <jats:styled-content style=\"fixed-case\">CVD<\/jats:styled-content>\n                      events. We estimated\n                      <jats:styled-content style=\"fixed-case\">CVD<\/jats:styled-content>\n                      risks in relation to abruption from Cox proportional hazards regression following adjustments for confounders.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      With 13\u00a0231\u00a0562 person\u2010years of follow\u2010up of women with at least one delivery, 11\u00a0829 pregnancies were complicated by abruption. The median (interquartile range) follow\u2010up in the non\u2010abruption and abruption groups was 16 (8, 24) and 18 (10, 25) years, respectively.\n                      <jats:styled-content style=\"fixed-case\">CVD<\/jats:styled-content>\n                      mortality rates in women with and without abruption were 0.9 and 0.3 per 10\u00a0000 person\u2010years, respectively (adjusted hazard ratio (\n                      <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\n                      ) 2.7, 95% confidence interval (\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      ) 1.5, 5.0). The corresponding\n                      <jats:styled-content style=\"fixed-case\">CVD<\/jats:styled-content>\n                      morbidity complication rates were 16.7 and 10.0 per 10\u00a0000 person\u2010years, respectively (\n                      <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\n                      1.5, 95%\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      1.4, 1.8). The increased risks were evident for ischaemic heart disease, acute myocardial infarction, hypertensive heart disease, non\u2010rheumatic valvular disease, and congestive heart failure.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      This study shows increased hazards of\n                      <jats:styled-content style=\"fixed-case\">CVD<\/jats:styled-content>\n                      morbidity and mortality in relation to abruption. A better understanding of the pathogenesis of distorted placental microvasculature is needed as this appears to be a harbinger of\n                      <jats:styled-content style=\"fixed-case\">CVD<\/jats:styled-content>\n                      later in life.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ppe.12347","type":"journal-article","created":{"date-parts":[[2017,2,21]],"date-time":"2017-02-21T12:26:51Z","timestamp":1487680011000},"page":"209-218","source":"Crossref","is-referenced-by-count":29,"title":["Cardiovascular Disease in Relation to Placental Abruption: A\u00a0Population\u2010Based Cohort Study from Denmark"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0410-2595","authenticated-orcid":false,"given":"Cande V.","family":"Ananth","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology College of Physicians and Surgeons Columbia University New York NY"},{"name":"Department of Epidemiology Joseph L. Mailman School of Public Health Columbia University New York NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne Vinkel","family":"Hansen","sequence":"additional","affiliation":[{"name":"Department of Public Health University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle A.","family":"Williams","sequence":"additional","affiliation":[{"name":"Department of Epidemiology TH Chan School of Public Health Harvard University Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne\u2010Marie","family":"Nybo Andersen","sequence":"additional","affiliation":[{"name":"Department of Public Health University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,2,21]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3016.2010.01120.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.110.150078"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)03406-1"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0412.2011.01355.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annepidem.2010.05.007"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyq270"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2015.06.001"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/ppe.12089"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-015-0067-9"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.111.00930"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2006.05.021"},{"key":"e_1_2_6_13_1","volume-title":"Placental Abruption: Clinical Features and Diagnosis","author":"Ananth CV","year":"2014"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0412.2000.079006496.x"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0412.2010.01030.x"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/153.4.332"},{"key":"e_1_2_6_17_1","first-page":"441","article-title":"The Danish Civil Registration System. 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