{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T17:46:27Z","timestamp":1758476787581,"version":"3.37.3"},"reference-count":28,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,5,2]],"date-time":"2017-05-02T00:00:00Z","timestamp":1493683200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"the National Key Research and Development Program, Ministry of Science and Technology, P.R. China","award":["2016YFC1000501"],"award-info":[{"award-number":["2016YFC1000501"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Paediatric Perinatal Epid"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The objectives of this study were to explore the prevalence of neural tube defects (NTDs) in three districts of Beijing, and to evaluate the impact of prenatal diagnosis on the prevalence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data were collected between 2006 and 2012 from the Beijing Birth Defects Surveillance System. P<jats:sub>13<\/jats:sub> and P<jats:sub>28<\/jats:sub> represent the prevalence of <jats:styled-content style=\"fixed-case\">NTD<\/jats:styled-content>s diagnosed from 13\u00a0weeks and 28\u00a0weeks of gestation, respectively, to 7\u00a0days after delivery. Populations were classified as household (permanent) and non\u2010household (non\u2010permanent) because differences exist in access to health care, education, and income, among others.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The P<jats:sub>13<\/jats:sub> of <jats:styled-content style=\"fixed-case\">NTD<\/jats:styled-content>s was 11.7 per 10 000 births in the three districts, which declined from 2006\u201312. In addition, the prevalence of <jats:styled-content style=\"fixed-case\">NTD<\/jats:styled-content>s in the non\u2010household population was 1.7\u2010fold higher than that among the household population. The P<jats:sub>13<\/jats:sub> of anencephaly, spina bifida, and encephalocele were 5.3, 4.9, 1.6, respectively, per 10 000 births. The P<jats:sub>28<\/jats:sub> of <jats:styled-content style=\"fixed-case\">NTD<\/jats:styled-content>s only represented 29.1% of P<jats:sub>13<\/jats:sub>, and this proportion decreased over the 7\u2010year period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The prevalence of <jats:styled-content style=\"fixed-case\">NTD<\/jats:styled-content>s remains high in the three districts of Beijing, and the rate was higher in the non\u2010household than household population. The prevalence of birth defects would be under estimated by almost 70 per cent if the report time was set on 28\u00a0weeks\u2019 gestation or later compared with report time on 13\u00a0weeks of gestation. It is better to set the report time earlier in birth defect surveillance in contemporary China.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ppe.12354","type":"journal-article","created":{"date-parts":[[2017,5,2]],"date-time":"2017-05-02T17:41:58Z","timestamp":1493746918000},"page":"293-300","source":"Crossref","is-referenced-by-count":12,"title":["Prevalence of Neural Tube Defects and the Impact of Prenatal Diagnosis in Three Districts of Beijing, China"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5888-2454","authenticated-orcid":false,"given":"Lei","family":"Jin","sequence":"first","affiliation":[{"name":"Institute of Reproductive and Child Health Peking University\/Key Laboratory of Reproductive Health National Health and Family Planning Commission of the People's Republic of China Beijing China"},{"name":"Department of Epidemiology and Biostatistics School of Public Health Peking University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Jin","sequence":"additional","affiliation":[{"name":"Maternal and Child Health Hospital Tongzhou District of Beijing"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingru","family":"Yu","sequence":"additional","affiliation":[{"name":"Institute of Reproductive and Child Health Peking University\/Key Laboratory of Reproductive Health National Health and Family Planning Commission of the People's Republic of China Beijing China"},{"name":"Department of Epidemiology and Biostatistics School of Public Health Peking University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanjun","family":"Xu","sequence":"additional","affiliation":[{"name":"Maternal and Child Health Hospital Shunyi District of Beijing"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Liu","sequence":"additional","affiliation":[{"name":"Maternal and Child Health Hospital Fangshan District of Beijing"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aiguo","family":"Ren","sequence":"additional","affiliation":[{"name":"Institute of Reproductive and Child Health Peking University\/Key Laboratory of Reproductive Health National Health and Family Planning Commission of the People's Republic of China Beijing China"},{"name":"Department of Epidemiology and Biostatistics School of Public Health Peking University"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,5,2]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.23238"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-90-481-9485-8_20"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(91)90133-A"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199212243272602"},{"key":"e_1_2_8_6_1","first-page":"6","article-title":"Supplement use and other characteristics among pregnant women with a previous pregnancy affected by a neural tube defect \u2010 United States, 1997\u20102009","volume":"64","author":"Arth A","year":"2015","journal-title":"Morbidity and Mortality Weekly Report"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a009766"},{"volume-title":"Atlas of Birth Defects in the People's Republic Of China","year":"1992","author":"Collaborating groups of birth defects surveillance in China","key":"e_1_2_8_8_1"},{"key":"e_1_2_8_9_1","unstructured":"Ministry of Health of the People's Republic of China.Birth Defects Prevention and Control in China 2012.http:\/\/www.moh.gov.cn\/wsb\/pxwfb\/201209\/55840\/files\/0af7007b1a68469397531b154d9425f9.pdf; 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