{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T18:26:57Z","timestamp":1787164017602,"version":"build-2736575974"},"reference-count":27,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,9,7]],"date-time":"2017-09-07T00:00:00Z","timestamp":1504742400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"National Health and Medical Research Council Centre for Research Excellence","award":["APP1001066"],"award-info":[{"award-number":["APP1001066"]}]},{"name":"National Health and Medical Research Council Centre for Research Excellence","award":["FT120100069"],"award-info":[{"award-number":["FT120100069"]}]},{"name":"New South Wales Population Health and Health Services Research Support Program","award":["APP1001066"],"award-info":[{"award-number":["APP1001066"]}]},{"name":"New South Wales Population Health and Health Services Research Support Program","award":["FT120100069"],"award-info":[{"award-number":["FT120100069"]}]},{"name":"Australian Research Council Future Fellowship","award":["APP1001066"],"award-info":[{"award-number":["APP1001066"]}]},{"name":"Australian Research Council Future Fellowship","award":["FT120100069"],"award-info":[{"award-number":["FT120100069"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Paediatric Perinatal Epid"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Gallstone disease is a leading indication for non\u2010obstetric abdominal surgery during pregnancy. There are limited whole population data on maternal and neonatal outcomes. This population\u2010based study aims to describe the outcomes of gallstone disease during pregnancy in an Australian setting.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Linked hospital, birth, and mortality data for all women with singleton pregnancies in New South Wales, Australia, 2001\u20132012 were analysed. Exposure of interest was gallstone disease (acute biliary pancreatitis, gallstones with\/without cholecystitis). Outcomes including preterm birth (spontaneous and planned), readmission, morbidity and mortality (maternal and neonatal) were compared between pregnancies with and without gallstone disease. Adjusted risk ratios (\n                      <jats:styled-content style=\"fixed-case\">aRR<\/jats:styled-content>\n                      s) and 99% confidence intervals were estimated using modified Poisson regression and adjusted for maternal and pregnancy factors.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 1 064 089 pregnancies, 1882 (0.18%) had gallstone disease. Of these, 239 (12.7%) had an antepartum cholecystectomy and 1643 (87.3%) were managed conservatively. Of those managed conservatively, 319 (19.0%) had a postpartum cholecystectomy. Gallstone disease was associated with increased risk of preterm birth (\n                      <jats:styled-content style=\"fixed-case\">aRR<\/jats:styled-content>\n                      1.3, 99%\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      1.1, 1.6), particularly planned preterm birth (\n                      <jats:styled-content style=\"fixed-case\">aRR<\/jats:styled-content>\n                      1.6, 99%\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      1.2, 2.1), maternal morbidity (\n                      <jats:styled-content style=\"fixed-case\">aRR<\/jats:styled-content>\n                      1.6, 99%\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      1.1, 2.3), maternal readmission (\n                      <jats:styled-content style=\"fixed-case\">aRR<\/jats:styled-content>\n                      4.7, 99%\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      4.2, 5.3), and neonatal morbidity (\n                      <jats:styled-content style=\"fixed-case\">aRR<\/jats:styled-content>\n                      1.4, 99%\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      1.1, 1.7). Surgery was associated with decreased risk of maternal readmission (\n                      <jats:styled-content style=\"fixed-case\">aRR<\/jats:styled-content>\n                      0.4, 99%\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      0.2, 0.7).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Gallstone disease during pregnancy was associated with adverse maternal and neonatal outcomes. Most women with gallstone disease during pregnancy are managed conservatively. Surgical management was associated with decreased risk of readmission.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ppe.12406","type":"journal-article","created":{"date-parts":[[2017,9,7]],"date-time":"2017-09-07T16:04:37Z","timestamp":1504800277000},"page":"522-530","source":"Crossref","is-referenced-by-count":46,"title":["Outcomes of Gallstone Disease during Pregnancy: a Population\u2010based Data Linkage Study"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6024-2958","authenticated-orcid":false,"given":"Ibinabo","family":"Ibiebele","sequence":"first","affiliation":[{"name":"Clinical and Population Perinatal Health Research Kolling Institute Northern Sydney Local Health District Sydney NSW Australia"},{"name":"Sydney Medical School Northern University of Sydney Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret","family":"Schnitzler","sequence":"additional","affiliation":[{"name":"Sydney Medical School Northern University of Sydney Sydney NSW Australia"},{"name":"Department of Gastrointestinal Surgery Royal North Shore Hospital Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanya","family":"Nippita","sequence":"additional","affiliation":[{"name":"Clinical and Population Perinatal Health Research Kolling Institute Northern Sydney Local Health District Sydney NSW Australia"},{"name":"Sydney Medical School Northern University of Sydney Sydney NSW Australia"},{"name":"Department of Obstetrics and Gynaecology Royal North Shore Hospital Northern Sydney Local Health District Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane B.","family":"Ford","sequence":"additional","affiliation":[{"name":"Clinical and Population Perinatal Health Research Kolling Institute Northern Sydney Local Health District Sydney NSW Australia"},{"name":"Sydney Medical School Northern University of Sydney Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,9,7]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-7125(16)31633-9"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2008.01.015"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/GRF.0b013e3181c11d10"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2015.05.005"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2016.01.070"},{"key":"e_1_2_6_7_1","first-page":"53","article-title":"Surgery for gallstone disease during pregnancy does not increase fetal or maternal mortality: a meta\u2010analysis","volume":"5","author":"Athwal R","year":"2016","journal-title":"Hepatobiliary Surgery and Nutrition"},{"key":"e_1_2_6_8_1","unstructured":"NSW Ministry of Health.Centre for Health Record Linkage: How Record Linkage Works. 2016 [cited 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