{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T19:11:22Z","timestamp":1781550682076,"version":"3.54.5"},"reference-count":33,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,1,2]],"date-time":"2018-01-02T00:00:00Z","timestamp":1514851200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81673181"],"award-info":[{"award-number":["81673181"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Paediatric Perinatal Epid"],"published-print":{"date-parts":[[2018,3]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>In January 2016, a universal two\u2010child policy was introduced in China. The association of interpregnancy interval (IPI<\/jats:styled-content>) with perinatal outcomes has not previously been assessed among Chinese population. We investigated the effect of IPI<\/jats:styled-content> after live birth on the risks of preterm delivery, and small, and large for gestational age births in China.<\/jats:p><\/jats:sec>Methods<\/jats:title>We conducted a cohort study among 227 352 Chinese women with their first and second delivery during 2000 to 2015. IPI<\/jats:styled-content> was calculated as months from first live delivery to conception of the second pregnancy. Poisson regression models with robust variance were fit to evaluate associations of IPI<\/jats:styled-content> with risk of adverse perinatal outcomes, adjusted for potential confounders.<\/jats:p><\/jats:sec>Results<\/jats:title>Compared to IPI<\/jats:styled-content> of 24\u2010 <30 months, IPI<\/jats:styled-content> <18 months was associated with higher risks of preterm birth (PTB<\/jats:styled-content>) and small for gestational age (SGA<\/jats:styled-content>). For IPI<\/jats:styled-content> <6 months, the adjusted relative risks (RR<\/jats:styled-content>) for PTB<\/jats:styled-content> and SGA<\/jats:styled-content> were 2.04 (95% confidence interval [CI<\/jats:styled-content>] 1.83, 2.27) and 1.43 (95% CI<\/jats:styled-content> 1.31, 1.57), respectively. Women with IPI<\/jats:styled-content> \u226560 months had higher risks of PTB<\/jats:styled-content> and large for gestational age (LGA<\/jats:styled-content>). For IPI<\/jats:styled-content> \u2265120 months, the adjusted RR<\/jats:styled-content>s for PTB<\/jats:styled-content> and LGA<\/jats:styled-content> were 1.67 (95% CI<\/jats:styled-content> 1.43, 1.94) and 1.10 (95% CI<\/jats:styled-content> 0.97, 1.26).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Women with IPI<\/jats:styled-content> <18 months after live birth had higher risk of PTB<\/jats:styled-content> and SGA<\/jats:styled-content>, and IPI<\/jats:styled-content> \u226560 months was associated with higher risk of PTB<\/jats:styled-content> and LGA<\/jats:styled-content>. These findings may provide information to Chinese couples about the appropriate interpregnancy interval for a second pregnancy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ppe.12432","type":"journal-article","created":{"date-parts":[[2018,1,2]],"date-time":"2018-01-02T13:53:58Z","timestamp":1514901238000},"page":"131-140","source":"Crossref","is-referenced-by-count":36,"title":["Effect of Interpregnancy Interval on Adverse Perinatal Outcomes in Southern China: A Retrospective Cohort Study, 2000\u20132015"],"prefix":"10.1111","volume":"32","author":[{"given":"Lifang","family":"Zhang","sequence":"first","affiliation":[{"name":"Division of Birth Cohort Study Guangzhou Women and Children's Medical Center Guangzhou Medical University Guangzhou China"},{"name":"Department of Woman and Child Health Care Guangzhou Women and Children's Medical Center Guangzhou Medical University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Songying","family":"Shen","sequence":"additional","affiliation":[{"name":"Division of Birth Cohort Study Guangzhou Women and Children's Medical Center Guangzhou Medical University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianrong","family":"He","sequence":"additional","affiliation":[{"name":"Division of Birth Cohort Study Guangzhou Women and Children's Medical Center Guangzhou Medical University Guangzhou China"},{"name":"Department of Woman and Child Health Care Guangzhou Women and Children's Medical Center Guangzhou Medical University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fanfan","family":"Chan","sequence":"additional","affiliation":[{"name":"Division of Birth Cohort Study Guangzhou Women and Children's Medical Center Guangzhou Medical University Guangzhou China"},{"name":"Department of Woman and Child Health Care Guangzhou Women and Children's Medical Center Guangzhou Medical University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinhua","family":"Lu","sequence":"additional","affiliation":[{"name":"Division of Birth Cohort Study Guangzhou Women and Children's Medical Center Guangzhou Medical University Guangzhou China"},{"name":"Department of Woman and Child Health Care Guangzhou Women and Children's Medical Center Guangzhou Medical University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weidong","family":"Li","sequence":"additional","affiliation":[{"name":"Division of Birth Cohort Study Guangzhou Women and Children's Medical Center Guangzhou Medical University Guangzhou China"},{"name":"Department of Woman and Child Health Care Guangzhou Women and Children's Medical Center Guangzhou Medical University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Wang","sequence":"additional","affiliation":[{"name":"Division of Birth Cohort Study Guangzhou Women and Children's Medical Center Guangzhou Medical University Guangzhou China"},{"name":"Department of Woman and Child Health Care Guangzhou Women and Children's Medical Center Guangzhou Medical University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kin Bong H.","family":"Lam","sequence":"additional","affiliation":[{"name":"Nuffield Department of Population Health University of Oxford Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ben W. J.","family":"Mol","sequence":"additional","affiliation":[{"name":"The Robinson Research Institute School of Pediatrics and Reproductive Health University of Adelaide Adelaide SA Australia"},{"name":"Institute of Applied Health Research University of Birmingham Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiu Lun A.","family":"Yeung","sequence":"additional","affiliation":[{"name":"Li Ka Shing Faculty of Medicine School of Public Health The University of Hong Kong Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huimin","family":"Xia","sequence":"additional","affiliation":[{"name":"Division of Birth Cohort Study Guangzhou Women and Children's Medical Center Guangzhou Medical University Guangzhou China"},{"name":"Department of Neonatal Surgery Guangzhou Women and Children's Medical Center Guangzhou Medical University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. Mary","family":"Schooling","sequence":"additional","affiliation":[{"name":"Li Ka Shing Faculty of Medicine School of Public Health The University of Hong Kong Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1248-229X","authenticated-orcid":false,"given":"Xiu","family":"Qiu","sequence":"additional","affiliation":[{"name":"Division of Birth Cohort Study Guangzhou Women and Children's Medical Center Guangzhou Medical University Guangzhou China"},{"name":"Department of Woman and Child Health Care Guangzhou Women and Children's Medical Center Guangzhou Medical University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,1,2]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.14165"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.g4333"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.295.15.1809"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(01)07105-7"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000171118.79529.a3"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1728-4465.2012.00308.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.16279"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)31405-2"},{"key":"e_1_2_7_10_1","unstructured":"W X. 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