{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T21:25:39Z","timestamp":1776461139197,"version":"3.51.2"},"reference-count":35,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,3,23]],"date-time":"2018-03-23T00:00:00Z","timestamp":1521763200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","award":["639377"],"award-info":[{"award-number":["639377"]}],"id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Paediatric Perinatal Epid"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Triptans are commonly used to treat migraine headaches, but data on the long\u2010term safety of these medications during pregnancy are sparse. Triptans have a biologically plausible mechanism for effects on the fetal brain through binding to 5\u2010HT<jats:sub>1<\/jats:sub>\u2010receptors, and previous studies show increased risks of externalising behaviour problems in toddlers exposed to triptans during pregnancy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We included 3784 children in the Norwegian Mother and Child Cohort Study, whose mothers returned the 5\u2010year\u2010questionnaire and reported a history of migraine or triptan use; 353 (9.3%) mothers reported use of triptans during pregnancy, 1509 (39.9%) reported migraine during pregnancy but no triptan use, and 1922 (50.8%) had migraine prior to pregnancy only. We used linear and log\u2010binomial models with inverse probability weights to examine the association between prenatal triptan exposure and internalising and externalising behaviour, communication, and temperament in 5\u2010year\u2010old children.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Triptan\u2010exposed children scored higher on the sociability trait than unexposed children of mothers with migraine (\u03b2 1.66, 95% confidence interval [0.30, 3.02]). We found no other differences in temperament, or increased risk of behaviour or communication problems.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Contrary to results from previous studies in younger children, we found no increased risk of externalising behaviour problems in 5\u2010year\u2010old children exposed to triptans in fetal life. Triptan\u2010exposed children did have slightly more sociable temperaments, but the clinical meaning of this finding is uncertain.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ppe.12461","type":"journal-article","created":{"date-parts":[[2018,3,23]],"date-time":"2018-03-23T07:46:52Z","timestamp":1521791212000},"page":"247-255","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Prenatal triptan exposure and neurodevelopmental outcomes in 5\u2010year\u2010old children: Follow\u2010up from the Norwegian Mother and Child Cohort Study"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3675-371X","authenticated-orcid":false,"given":"Gerd\u2010Marie Eskerud","family":"Harris","sequence":"first","affiliation":[{"name":"Pharmacoepidemiology &amp; Drug Safety Research Group School of Pharmacy Faculty of Mathematics and Natural Sciences University of Oslo  Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9302-2641","authenticated-orcid":false,"given":"Mollie","family":"Wood","sequence":"additional","affiliation":[{"name":"Pharmacoepidemiology &amp; Drug Safety Research Group School of Pharmacy Faculty of Mathematics and Natural Sciences University of Oslo  Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eivind","family":"Ystrom","sequence":"additional","affiliation":[{"name":"Pharmacoepidemiology &amp; Drug Safety Research Group School of Pharmacy Faculty of Mathematics and Natural Sciences University of Oslo  Oslo Norway"},{"name":"Department of Mental Disorders Norwegian Institute of Public Health  Oslo Norway"},{"name":"Department of Psychology University of Oslo  Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6361-2918","authenticated-orcid":false,"given":"Hedvig","family":"Nordeng","sequence":"additional","affiliation":[{"name":"Pharmacoepidemiology &amp; Drug Safety Research Group School of Pharmacy Faculty of Mathematics and Natural Sciences University of Oslo  Oslo Norway"},{"name":"Department of Child Health and Development Norwegian Institute of Public Health  Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,3,23]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7610.2010.02309.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0051564"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn1896"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2006.01184.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2009.01869.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-016-2127-9"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/head.12500"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.2011.01961.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyt183"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2013.4914"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2016-3840"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/ppe.12253"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2016-011971"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.3902"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyw029"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3016.2009.01062.x"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1080\/03009742.1998.11720780"},{"key":"e_1_2_7_19_1","unstructured":"ATC\/DDD index2017 [Internet].World Health Organization Collaborating Centre for Drugs Statistics Methodology.http:\/\/www.whocc.no\/atc_ddd_index\/. 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