{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T20:09:33Z","timestamp":1793563773369,"version":"4.5.0"},"reference-count":15,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,8,31]],"date-time":"2018-08-31T00:00:00Z","timestamp":1535673600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Regional funding for hospital research","award":["PHRC 2008 no. BRD 08-06-T"],"award-info":[{"award-number":["PHRC 2008 no. BRD 08-06-T"]}]},{"name":"Groupe de Pathologie Infectieuse P\u00e9diatrique (GPIP), Groupe Francophone de R\u00e9animation et Urgences P\u00e9diatriques (GFRUP), Soci\u00e9t\u00e9 Fran\u00e7aise de P\u00e9diatrie - Pampers."}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Paediatric Perinatal Epid"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>In a context of suboptimal vaccination coverage and increasing vaccine hesitancy, we aimed to study morbidity and mortality in children related to missing or incomplete meningococcal C and pneumococcal conjugate vaccines.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a prospective, observational, population\u2010based study from 2009 to 2014 in a French administrative area that included all children from age 1\u00a0month to 16\u00a0years who died before admission or were admitted to an intensive care unit for a community\u2010onset bacterial infection. Vaccine\u2010preventable infection was defined as an infection with an identified serotype included in the national vaccine schedule at the time of infection and occurring in a non\u2010 or incompletely vaccinated child. Death and severe sequelae were studied at hospital discharge. Frequencies of vaccine\u2010preventable morbidity and mortality caused by meningococcus and pneumococcus were calculated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among the 124 children with serotyped meningococcal (n\u00a0=\u00a075) or pneumococcal (n\u00a0=\u00a049) severe infections included (median age 26\u00a0months), 20 (16%) died and 12 (10%) had severe sequelae. Vaccine\u2010preventable infections accounted for 18\/124 infections (15%, 95% CI 9, 22), 5\/20 deaths (25%, 95% CI 9, 49), and 3\/12 severe sequelae cases (25%, 95% CI 0, 54). The vaccine schedule for meningococcal C and pneumococcal conjugate vaccinations was incomplete for 71\/116 (61%) children targeted by at least one of these two vaccination programs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Mortality and morbidity rates related to vaccine\u2010preventable meningococcal or pneumococcal infection could be reduced by one quarter with better implementation of immunisation programs. Such information could help enhance the perception of vaccine benefits and fight vaccine hesitancy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ppe.12500","type":"journal-article","created":{"date-parts":[[2018,8,31]],"date-time":"2018-08-31T23:33:01Z","timestamp":1535758381000},"page":"442-447","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Vaccine\u2010preventable severe morbidity and mortality caused by meningococcus and pneumococcus: A population\u2010based study in France"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0921-4622","authenticated-orcid":false,"given":"Fleur","family":"Lorton","sequence":"first","affiliation":[{"name":"Centre d'investigation clinique INSERM 1413 Femme Enfant Adolescent CHU de Nantes  Nantes France"},{"name":"Inserm UMR 1153 Obstetrical, Perinatal and Pediatric Epidemiology Research Team (Epop\u00e9) Center for Epidemiology and Statistics Sorbonne Paris Cit\u00e9 (CRESS) Paris Descartes University  Paris France"},{"name":"Services d'urgences p\u00e9diatriques et de p\u00e9diatrie g\u00e9n\u00e9rale H\u00f4pital Femme Enfant Adolescent  Nantes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Chalumeau","sequence":"additional","affiliation":[{"name":"Inserm UMR 1153 Obstetrical, Perinatal and Pediatric Epidemiology Research Team (Epop\u00e9) Center for Epidemiology and Statistics Sorbonne Paris Cit\u00e9 (CRESS) Paris Descartes University  Paris France"},{"name":"Department of General Pediatrics and Pediatric Infectious Diseases Necker hospital for Sick Children  Paris France"},{"name":"Assistance Publique\u2010H\u00f4pitaux de Paris Paris Descartes University  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R\u00e9my","family":"Assathiany","sequence":"additional","affiliation":[{"name":"Association pour le Recherche et l'Enseignement en P\u00e9diatrie G\u00e9n\u00e9rale (AREPEGE)  Versailles France"},{"name":"Cabinet de P\u00e9diatrie Association Fran\u00e7aise de P\u00e9diatrie Ambulatoire (AFPA)  Issy\u2010les\u2010Moulineaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain","family":"Martinot","sequence":"additional","affiliation":[{"name":"EA2694 Univ. Lille, CHU Lille  Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Bucchia","sequence":"additional","affiliation":[{"name":"Services d'urgences p\u00e9diatriques et de p\u00e9diatrie g\u00e9n\u00e9rale H\u00f4pital Femme Enfant Adolescent  Nantes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Michel","family":"Rou\u00e9","sequence":"additional","affiliation":[{"name":"Service de r\u00e9animation p\u00e9diatrique et n\u00e9onatale H\u00f4pital Morvan, CHU de Brest  Brest France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Bourgoin","sequence":"additional","affiliation":[{"name":"Service de r\u00e9animation p\u00e9diatrique et n\u00e9onatale H\u00f4pital Femme Enfant Adolescent, CHU de Nantes  Nantes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Chantreuil","sequence":"additional","affiliation":[{"name":"Service de 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