{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T11:31:09Z","timestamp":1781782269141,"version":"3.54.5"},"reference-count":34,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,5,27]],"date-time":"2019-05-27T00:00:00Z","timestamp":1558915200000},"content-version":"vor","delay-in-days":26,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Paediatric Perinatal Epid"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Placental abruption is a major determinant of maternal and perinatal morbidity and mortality, often related to asphyxia and preterm birth. However, the impact of abruption on the long\u2010term morbidity of the offspring is less investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We designed a hospital\u2010based cohort study, in which the incidence of long\u2010term neurology\u2010related hospitalisations of offspring to women with and without placental abruption was assessed. All singleton deliveries between 1991 and 2014 were included in the study. Congenital anomalies, perinatal mortality, and multifetal pregnancies were excluded from the analyses. We compared cumulative morbidity incidence using Kaplan\u2010Meier survival curves and estimated the risk for long\u2010term neurological hospitalisations from Cox proportional hazards models after adjustment for putative including maternal age, parity, hypertensive disorders, pre\u2010gestational and gestational diabetes, gender, ethnicity, and year of birth.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Over the 22\u2010year period, 2\u00a0202\u00a0269 person\u2010years of follow\u2010up, there were 217\u00a0910 deliveries of which 0.5% (n\u00a0=\u00a01003) were complicated with placental abruption. The median (interquartile range) follow\u2010up of children in the abruption and non\u2010abruption groups was 10.3 (4.6, 15.9) and 12.0 (6.3, 16.5) years, respectively. The cumulative incidence of total neurological hospitalisations was comparable between abruption (3.32 per 1000 person\u2010years) and non\u2010abruption (3.16 per 1000 person\u2010years). Abruption was associated with increased rates of cerebral palsy (hazard ratio [HR] 6.71, 95% CI 3.32, 13.58) and developmental disorders (HR 3.36, 95% CI 1.38, 8.13), but not for total neurology\u2010related hospitalisations (HR 1.08, 95% CI 0.78, 1.49).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Placental abruption is associated with increased rate of cerebral palsy and developmental disorders in the offspring later in life. This study may define risk factors for childhood neuropsychiatric disorders, enabling early diagnosis and intervention in children with such disorders, and perhaps improving their prognosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ppe.12553","type":"journal-article","created":{"date-parts":[[2019,5,27]],"date-time":"2019-05-27T11:01:35Z","timestamp":1558954895000},"page":"215-222","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Placental abruption and long\u2010term neurological hospitalisations in the offspring"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6484-3769","authenticated-orcid":false,"given":"Gali","family":"Pariente","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Soroka University Medical Center Ben\u2010Gurion University of the Negev Beer\u2010Sheva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9057-4961","authenticated-orcid":false,"given":"Tamar","family":"Wainstock","sequence":"additional","affiliation":[{"name":"Department of Public Health, Faculty of Health Sciences Ben\u2010Gurion University of the Negev Beer\u2010Sheva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0201-9691","authenticated-orcid":false,"given":"Asnat","family":"Walfisch","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Soroka University Medical Center Ben\u2010Gurion University of the Negev Beer\u2010Sheva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniella","family":"Landau","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Soroka University Medical Center, Faculty of Health Sciences Ben\u2010Gurion University of the Negev Beer\u2010Sheva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0454-6874","authenticated-orcid":false,"given":"Eyal","family":"Sheiner","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Soroka University Medical Center Ben\u2010Gurion University of the Negev Beer\u2010Sheva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,5,27]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2010.511346"},{"issue":"272","key":"e_1_2_7_3_1","first-page":"e1","article-title":"Severe placental abruption: clinical definition and associations with maternal complications","volume":"214","author":"Ananth CV","year":"2015","journal-title":"Am J Obstet Gynecol"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/jmf.11.1.34.39"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/jmf.13.1.45.49"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/153.4.332"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1599149"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0125246"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2014.05.026"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0030-1249761"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2015.1015984"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwr045"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1375\/twin.8.5.524"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2006.05.021"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.282.17.1646"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2431-8-49"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/08830738050200080401"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000247174.27979.6b"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2008.01896.x"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2014.929109"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2012.08.015"},{"key":"e_1_2_7_22_1","unstructured":"SegelS.Can universal healthcare work? 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