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A small literature suggests maternal stress during pregnancy is associated with bronchiolitis. However, the association between maternal exposure to lifetime traumatic stress, including traumatic events occurring in childhood or throughout the life course, and bronchiolitis has not been studied previously.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To investigate the association between maternal exposure to total lifetime and childhood traumatic stress events and infant bronchiolitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We studied mother\u2010infant dyads enrolled in a prospective prenatal cohort, recruited 2006\u20102011, and Tennessee Medicaid. During pregnancy, we assessed maternal lifetime exposure to types of traumatic events by questionnaire. We captured bronchiolitis diagnoses in term, non\u2010low birthweight infants\u2019 first 12\u00a0months using linked Medicaid data. In separate models, we assessed the association of maternal lifetime traumatic events (0 to 20 types) and a subset of traumatic events that occurred during childhood (0 to 3: family violence, sexual, and physical abuse) and infant bronchiolitis using multivariable log\u2010binomial models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 629 women, 85% were African American. The median count (interquartile range) of lifetime traumatic events was 3 (2, 5); 42% reported \u22651 childhood traumatic event. Among infants, 22% had a bronchiolitis diagnosis (0 to 2 lifetime traumatic events: 24%; 3 events: 20%; 4 to 5 events: 18%; 6 or more events: 24%). Total maternal lifetime traumatic events were not associated with bronchiolitis in multivariable analyses. For maternal childhood traumatic events, the risk of infant bronchiolitis increased with number of event types reported: adjusted Risk ratios were 1.12 (95% confidence interval [CI] 0.80, 1.59), 1.31 (95% CI 0.83, 2.07), and 2.65 (95% CI 1.45, 4.85) for 1, 2, and 3 events, respectively, vs none.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Infants born to women reporting multiple types of childhood trauma were at higher risk for bronchiolitis. Further research is needed to explore intergenerational effects of traumatic experiences.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ppe.12559","type":"journal-article","created":{"date-parts":[[2019,6,17]],"date-time":"2019-06-17T16:29:40Z","timestamp":1560788980000},"page":"262-270","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Maternal childhood and lifetime traumatic life events and infant bronchiolitis"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5951-5514","authenticated-orcid":false,"given":"Margaret A.","family":"Adgent","sequence":"first","affiliation":[{"name":"Division of General Pediatrics, Department of Pediatrics Vanderbilt University Medical Center Nashville Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omar","family":"Elsayed\u2010Ali","sequence":"additional","affiliation":[{"name":"Division of General Pediatrics, Department of Pediatrics Vanderbilt University Medical Center Nashville Tennessee"},{"name":"Emory University School of Medicine Atlanta Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tebeb","family":"Gebretsadik","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Vanderbilt University Medical Center Nashville Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frances A.","family":"Tylavsky","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine University of Tennessee Health Science Center Memphis Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet","family":"Kocak","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine University of Tennessee Health Science Center Memphis Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephania A.","family":"Cormier","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences Louisiana State University Baton Rouge Louisiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosalind J.","family":"Wright","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Kravis Children\u2019s Hospital Icahn School of Medicine at Mount Sinai New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kecia N.","family":"Carroll","sequence":"additional","affiliation":[{"name":"Division of General Pediatrics, Department of Pediatrics Vanderbilt University Medical Center Nashville Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,6,17]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2006-2223"},{"issue":"18","key":"e_1_2_7_3_1","first-page":"1793","article-title":"Viral bronchiolitis in children","volume":"374","author":"Meissner HC","year":"2016","journal-title":"N Engl J Med"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2007-2087"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a115243"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e31822e68e6"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2009.02.021"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsycho.2010.01.007"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3016.2007.00879.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00250.2013"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2002.124776"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.1003253"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10995-015-1777-z"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2009-3226"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2466-14-154"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00299-2015"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/PSY.0000000000000354"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.3109\/10253890.2015.1117447"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1089\/jwh.2011.2788"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0749-3797(98)00017-8"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1037\/a0039077"},{"key":"e_1_2_7_22_1","doi-asserted-by":"crossref","unstructured":"Sontag\u2010PadillaL BurnsRM ShihRA et al.The Urban Child Institute CANDLE Study: Methodological Overview and Baseline Sample Description 2015.https:\/\/www.rand.org\/pubs\/research_reports\/RR1336.html. 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