{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T21:44:53Z","timestamp":1789940693127,"version":"4.0.1"},"reference-count":39,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,7,25]],"date-time":"2019-07-25T00:00:00Z","timestamp":1564012800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002738","name":"Assistance Publique - H\u00f4pitaux de Paris","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002738","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007543","name":"Agence Nationale de S\u00e9curit\u00e9 du M\u00e9dicament et des Produits de Sant\u00e9","doi-asserted-by":"publisher","award":["AAP-2014-030"],"award-info":[{"award-number":["AAP-2014-030"]}],"id":[{"id":"10.13039\/501100007543","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Paediatric Perinatal Epid"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>There is no consensus about the ideal cervical ripening method to use for induction of labour.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To compare in current practice the effectiveness and safety of four cervical ripening methods.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a matched comparative study using data from the MEDIP prospective population\u2010based cohort conducted during one month in 2015 in all maternity units of seven French perinatal networks (3042 consecutive women with a live fetus and induction of labour). We analysed 1671 women with singleton cephalic fetus, unscarred uterus, and bishop score &lt;7. Dinoprostone vaginal pessary (reference) was compared to dinoprostone vaginal gel, misoprostol vaginal tablet, and balloon catheter. Effectiveness outcomes were the need for more than one induction agent, oxytocin use, failure to achieve vaginal delivery within 24\u00a0hours (VD\u00a0&lt;\u00a024\u00a0hours), and caesarean delivery. Safety outcomes were meconium\u2010stained amniotic fluid, uterine hyperstimulation, NICU admission, and post\u2010partum haemorrhage. Coarsened exact matching was used to balance confounders among the groups. Outcomes were compared using multivariable logistic regression models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared to the dinoprostone pessary (N\u00a0=\u00a01142, 68.3%), dinoprostone gel (N\u00a0=\u00a0335, 20.1%) was associated with less failure to achieve VD\u00a0&lt;\u00a024\u00a0hours (adjusted OR 0.66, 95% CI 0.47, 0.91). Misoprostol (N\u00a0=\u00a0103, 6.2%) was associated with less need of more than one induction agent (aOR 0.56, 95% CI 0.34, 0.92) and less oxytocin use (aOR 0.60, 95% CI 0.37, 0.99). The balloon catheter (N\u00a0=\u00a091, 5.4%) was associated with more failure to achieve VD\u00a0&lt;\u00a024\u00a0hours (aOR 2.62, 95% CI 1.37, 5.01), more caesarean delivery (aOR 1.84, 95% CI 1.09, 3.08), and less meconium\u2010stained amniotic fluid (aOR 0.12, 95% CI 0.02, 0.70). Uterine hyperstimulation rates seemed lower with the balloon catheter (1.2% vs 4.2% for the pessary).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In current practice, no cervical ripening method appears clearly superior to the others considering all effectiveness and safety outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ppe.12569","type":"journal-article","created":{"date-parts":[[2019,7,25]],"date-time":"2019-07-25T08:52:16Z","timestamp":1564044736000},"page":"313-322","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Comparison of effectiveness and safety of cervical ripening methods for induction of labour: A population\u2010based study using coarsened exact matching"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1614-0174","authenticated-orcid":false,"given":"Pauline","family":"Blanc\u2010Petitjean","sequence":"first","affiliation":[{"name":"Inserm UMR 1153, Obstetrical, Perinatal and Pediatric Epidemiology Research Team (EPOP\u00e9), Centre for Epidemiology and Statistics (CRESS), DHU Risks in Pregnancy Paris Descartes University Paris France"},{"name":"Assistance Publique\u2010H\u00f4pitaux de Paris, Louis Mourier Hospital, Department of Obstetrics and Gynecology, DHU Risks in Pregnancy Paris Diderot University Colombes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Carbonne","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Princess Grace Hospital Monaco\u2010Ville Monaco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6561-3321","authenticated-orcid":false,"given":"Catherine","family":"Deneux\u2010Tharaux","sequence":"additional","affiliation":[{"name":"Inserm UMR 1153, Obstetrical, Perinatal and Pediatric Epidemiology Research Team (EPOP\u00e9), Centre for Epidemiology and Statistics (CRESS), DHU Risks in Pregnancy Paris Descartes University Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Salom\u00e9","sequence":"additional","affiliation":[{"name":"URC\u2010CIC Paris Descartes Necker\/Cochin Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9643-0299","authenticated-orcid":false,"given":"Fran\u00e7ois","family":"Goffinet","sequence":"additional","affiliation":[{"name":"Inserm UMR 1153, Obstetrical, Perinatal and Pediatric Epidemiology Research Team (EPOP\u00e9), Centre for Epidemiology and Statistics (CRESS), DHU Risks in Pregnancy Paris Descartes University Paris France"},{"name":"Assistance Publique\u2010H\u00f4pitaux de Paris, Cochin Hospital, Port Royal Maternity Unit, DHU Risks in Pregnancy Paris Descartes University Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0891-1063","authenticated-orcid":false,"given":"Camille","family":"Le Ray","sequence":"additional","affiliation":[{"name":"Inserm UMR 1153, Obstetrical, Perinatal and Pediatric Epidemiology Research Team (EPOP\u00e9), Centre for Epidemiology and Statistics (CRESS), DHU Risks in Pregnancy Paris Descartes University Paris France"},{"name":"Assistance Publique\u2010H\u00f4pitaux de Paris, Cochin Hospital, Port Royal Maternity Unit, DHU Risks in Pregnancy Paris Descartes University Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the MEDIP study group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,7,25]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jogoh.2017.09.002"},{"key":"e_1_2_9_3_1","volume-title":"European perinatal health report, Health and Care of Pregnant Women and Babies in Europe in 2010","author":"Euro\u2010Peristat Project with SCPE and EUROCAT","year":"2013"},{"issue":"12","key":"e_1_2_9_4_1","first-page":"1","article-title":"Births: Final Data for 2014","volume":"64","author":"Hamilton BE","year":"2015","journal-title":"Natl Vital Stat Rep"},{"key":"e_1_2_9_5_1","first-page":"CD003246","article-title":"Intravenous oxytocin alone for cervical ripening and induction of labour","volume":"4","author":"Alfirevic Z","year":"2009","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_9_6_1","volume-title":"Induction of labour (Clinical Guideline No. 70), London, National Institute for Health and Clinical Excellence 2008","author":"NICE"},{"issue":"2","key":"e_1_2_9_7_1","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1097\/AOG.0b013e3181b48ef5","article-title":"ACOG Practice Bulletin No. 107: Induction of labor","volume":"114","author":"The American College of Obstetricians and Gynecologists","year":"2009","journal-title":"Obstet Gynecol"},{"key":"e_1_2_9_8_1","volume-title":"Recommandations professionnelles : D\u00e9clenchement artificiel du travail \u00e0 partir de 37 semaines d'am\u00e9norrh\u00e9e 2008","author":"Haute Autorit\u00e9 de Sant\u00e9 (HAS)"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jogoh.2017.11.006"},{"key":"e_1_2_9_10_1","first-page":"CD001233","article-title":"Mechanical methods for induction of labour","volume":"3","author":"Jozwiak M","year":"2012","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.14256"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.h217"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.13456"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)61930-3"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)17670-8"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1080\/0144361000074646"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/745159"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gyobfe.2013.11.002"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2016.1142965"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.15397"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1198\/jasa.2011.tm09599"},{"key":"e_1_2_9_22_1","volume-title":"Comparative Effectiveness of Matching Methods for Causal Inference (Unpublished Manuscript)","author":"King G","year":"2011"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/pan\/mpr013"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwk052"},{"key":"e_1_2_9_25_1","volume-title":"Statistical analysis with Missing data. 3rd Edition. Wiley Series in Probability and Statistics (Vol 793)","author":"Little RJA","year":"2019"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1017\/pan.2019.11"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016340903575998"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1080\/01443610802462522"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2014.883375"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1479-828X.2008.00901.x"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0368-2315(05)82672-9"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2015.1046828"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(97)00673-X"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(97)70154-6"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1080\/14767058.2017.1410791"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gyobfe.2015.03.008"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2012.05.020"},{"issue":"14","key":"e_1_2_9_38_1","doi-asserted-by":"crossref","first-page":"2382","DOI":"10.3109\/14767058.2015.1086331","article-title":"Controlled\u2010release dinoprostone insert versus Foley catheter for labor induction: a meta\u2010analysis","volume":"29","author":"Wang H","year":"2016","journal-title":"J Matern Fetal Neonatal Med"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2013.06.017"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1186\/1745-6215-16-S1-P4"}],"container-title":["Paediatric and Perinatal Epidemiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fppe.12569","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ppe.12569","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ppe.12569","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ppe.12569","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,9]],"date-time":"2023-09-09T18:36:46Z","timestamp":1694284606000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ppe.12569"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,25]]},"references-count":39,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2019,9]]}},"alternative-id":["10.1111\/ppe.12569"],"URL":"https:\/\/doi.org\/10.1111\/ppe.12569","archive":["Portico"],"relation":{},"ISSN":["0269-5022","1365-3016"],"issn-type":[{"value":"0269-5022","type":"print"},{"value":"1365-3016","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7,25]]},"assertion":[{"value":"2018-12-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-06-23","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-07-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}