{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T16:07:09Z","timestamp":1777997229175,"version":"3.51.4"},"reference-count":46,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,10,23]],"date-time":"2019-10-23T00:00:00Z","timestamp":1571788800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 HD059827"],"award-info":[{"award-number":["R01 HD059827"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T37 MD001449"],"award-info":[{"award-number":["T37 MD001449"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Paediatric Perinatal Epid"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Roughly, a fourth of all placental abruption cases have an acute aetiologic underpinning, but the causes of acute abruption are poorly understood. Studies indicate that symptoms of stress, depression, and anxiety during pregnancy may be associated with a higher risk of abruption.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>We examined the rate of abruption in the 2\u00a0hours immediately following outbursts of anger.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In a multicentre case\u2010crossover study, we interviewed 663 women diagnosed with placental abruption admitted to one of the seven Peruvian hospitals between January 2013 and August 2015. We asked women about outbursts of anger before symptom onset and compared this with their usual frequency of anger during the week before abruption.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The rate of abruption was 2.83\u2010fold (95% confidence interval [CI] 1.85, 4.33) higher in the 2\u00a0hours following an outburst of anger compared with other times. The rate ratio (RR) was lower for women who completed technical school or university (RR 1.38, 95% CI 0.52, 3.69) compared to women with secondary school education or less (RR 3.73, 95% CI 2.32, 5.99, <jats:italic>P<\/jats:italic>\u2010homogeneity\u00a0=\u00a0.07). There was no evidence that the association between anger episodes and abruption varied by hypertensive disorders of pregnancy (ie preeclampsia\/ eclampsia) or antepartum depressive symptoms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>There was a higher rate of abruption in the 2\u00a0hours following outbursts of anger compared with other times, providing potential clues to the aetiologic mechanisms of abruption of acute onset.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ppe.12591","type":"journal-article","created":{"date-parts":[[2019,10,23]],"date-time":"2019-10-23T09:21:54Z","timestamp":1571822514000},"page":"405-411","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Relation of outbursts of anger and the acute risk of placental abruption: A case\u2010crossover study"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4102-942X","authenticated-orcid":false,"given":"Harpreet S.","family":"Chahal","sequence":"first","affiliation":[{"name":"Department of Epidemiology Harvard T.H. Chan School of Public Health Boston MA USA"},{"name":"Mississauga Academy of Medicine University of Toronto Mississauga Mississauga ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7934-548X","authenticated-orcid":false,"given":"Bizu","family":"Gelaye","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Harvard T.H. Chan School of Public Health Boston MA USA"},{"name":"Department of Psychiatry Harvard Medical School Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth","family":"Mostofsky","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Harvard T.H. Chan School of Public Health Boston MA USA"},{"name":"Cardiovascular Epidemiology Research Unit Beth Israel Deaconess Medical Center Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuel S.","family":"Salazar","sequence":"additional","affiliation":[{"name":"Departamento de Gineco Obstetricia Universidad Nacional Mayor de San Marcos Lima Peru"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sixto E.","family":"Sanchez","sequence":"additional","affiliation":[{"name":"Facultad de Medicina Universidad de San Martin de Porres Lima Peru"},{"name":"Asociaci\u00f3n Civil Proyectos en Salud Lima Peru"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0410-2595","authenticated-orcid":false,"given":"Cande V.","family":"Ananth","sequence":"additional","affiliation":[{"name":"Division of Epidemiology and Biostatistics Department of Obstetrics, Gynecology, and Reproductive Sciences Rutgers Robert Wood Johnson Medical School New Brunswick NJ USA"},{"name":"Environmental and Occupational Health Sciences Institute (EOHSI) Rutgers Robert Wood Johnson Medical School Piscataway NJ USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelle A.","family":"Williams","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Harvard T.H. Chan School of Public Health Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,10,23]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000239439.04364.9a"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/153.4.332"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-0528.2003.02088.x"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-3782(93)90138-K"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/ppe.12347"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-015-0067-9"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.118.036748"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/ppe.12089"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)67726-4"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ede.0000073270.39780.e9"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/PSY.0b013e31820a62ce"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291713002353"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2010.07.024"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.1996.07030182.x"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpobgyn.2011.02.006"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2007.05.047"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2011.07.025"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehu033"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/EDE.0000000000000859"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/EDE.0000000000000605"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwy138"},{"key":"e_1_2_10_23_1","first-page":"266","article-title":"Panic attack\u2010associated placental abruption: a case report","volume":"50","author":"Cohen LS","year":"1989","journal-title":"J Clin Psychiatry"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2009.10.005"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a115853"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a117550"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyu081"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/EDE.0000000000000904"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525-1497.2001.016009606.x"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.92.7.1720"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1997.00440280091008"},{"key":"e_1_2_10_32_1","volume-title":"Modern Epidemiology","author":"Rothman KJ","year":"2008"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.genhosppsych.2014.09.009"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)02676-3"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.111.00550"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001648-199907000-00007"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2011.336"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2012.126"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.968776"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2013.03.035"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.116.023142"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semperi.2014.03.001"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000266983.77458.71"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1521-6926(02)00099-3"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(03)00823-3"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.71.6.1129"},{"key":"e_1_2_10_47_1","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1055\/s-0038-1646899","article-title":"Changes of plasma coagulation and fibrinolysis in response to mental stress","volume":"62","author":"Jern C","year":"1989","journal-title":"Thromb Haemost"}],"container-title":["Paediatric and Perinatal Epidemiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ppe.12591","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ppe.12591","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ppe.12591","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,9]],"date-time":"2023-09-09T00:14:47Z","timestamp":1694218487000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ppe.12591"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10,23]]},"references-count":46,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,11]]}},"alternative-id":["10.1111\/ppe.12591"],"URL":"https:\/\/doi.org\/10.1111\/ppe.12591","archive":["Portico"],"relation":{},"ISSN":["0269-5022","1365-3016"],"issn-type":[{"value":"0269-5022","type":"print"},{"value":"1365-3016","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,10,23]]},"assertion":[{"value":"2019-01-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-08-26","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-10-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}