{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T21:25:35Z","timestamp":1772054735943,"version":"3.50.1"},"reference-count":21,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,10,24]],"date-time":"2019-10-24T00:00:00Z","timestamp":1571875200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Paediatric Perinatal Epid"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>There are limited data available on the survival and early complications of preterm infants with less than 500\u00a0g birthweight. To estimate the outcomes for these infants, it is important for caregivers to be aware of perinatal factors that may affect survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>We assessed the mortality and certain early complications of preterm infants born with less than 500\u00a0g in Hungary between 2006 and 2015.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We reviewed data of 486 infants from the database of the Hungarian Central Statistical Office and in parallel of 407 infants from the \u201cNICU database.\u201d The study period was divided into two epochs: 2006\u20102010 and 2011\u20102015.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The survival was 27.1% in the first epoch and 39.1% in the second epoch, and the incidence of early complications was slightly higher in the second epoch. In the surviving group (first and second epoch combined), gestational age (25.1 vs 23.7\u00a0weeks), birthweight (458 vs 447\u00a0g) antenatal steroid treatment (66.3% vs 52.3%), surfactant therapy (95.1% vs 84.3%), median Apgar scores (6 vs 3 and 8 vs 5 at 1 and 5\u00a0minutes, respectively) and proportion of caesarean delivery (89.3% versus 68.5%) were higher than in the non\u2010surviving group (first and second epoch combined). The proportion of multiple births was lower in the surviving group (15.7% vs 33.4%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Survival of infants with less than 500\u00a0g improved between 2006\u20102010 and 2011\u20102015 in Hungary. The slightly higher occurrence of early complications might be associated with improving survival.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ppe.12598","type":"journal-article","created":{"date-parts":[[2019,10,25]],"date-time":"2019-10-25T03:44:01Z","timestamp":1571975041000},"page":"565-571","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Survival and early complications of preterm infants with birthweight less than 500 grams during a 10\u2010year period in Hungary"],"prefix":"10.1111","volume":"34","author":[{"given":"P\u00e9ter","family":"Varga","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Semmelweis University Budapest Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Botond","family":"Berecz","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Semmelweis University Budapest Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zs\u00f3fia","family":"Magyar","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Semmelweis University Budapest Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Pete","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Semmelweis University Budapest Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c9va","family":"Romicsn\u00e9 G\u00f6rbe","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Semmelweis University Budapest Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zs\u00f3fia Anna","family":"Dombi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Semmelweis University Budapest Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lilla","family":"Sassi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Semmelweis University Budapest Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eszter","family":"Fanczal","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Semmelweis University Budapest Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N\u00e1ndor","family":"\u00c1cs","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Semmelweis University Budapest Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L\u00e1szl\u00f3","family":"Kornya","sequence":"additional","affiliation":[{"name":"Central Hospital of South Pest\u2014National Institute of Hematology and Infectology Department of Obstetrics\u2010Gynecology and Gynecologic Oncology Budapest Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00f3zsef G\u00e1bor","family":"Jo\u00f3","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Semmelweis University Budapest Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Valek","sequence":"additional","affiliation":[{"name":"Heim P\u00e1l Children's Hospital Budapest Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c1gnes","family":"Harmath","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Semmelweis University Budapest Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3902-685X","authenticated-orcid":false,"given":"\u00c1kos","family":"Gasparics","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Semmelweis University Budapest Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,10,24]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/apa.12633"},{"key":"e_1_2_8_3_1","unstructured":"World Health Organization; 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