{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T02:39:35Z","timestamp":1775270375772,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,1,22]],"date-time":"2020-01-22T00:00:00Z","timestamp":1579651200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100004440","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["095582"],"award-info":[{"award-number":["095582"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Paediatric Perinatal Epid"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Over\u2010the\u2010counter analgesic use during pregnancy, particularly acetaminophen, may be associated with negative developmental outcomes in children.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>Estimate associations of prenatal and early\u2010life exposure to acetaminophen in early childhood with cognitive, motor, and language skills in two birth cohorts.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The American Project Viva cohort (1217 mother\u2010child pairs enrolled 1999\u20102002) assessed cognition at approximately 3\u00a0years using the Peabody Picture Vocabulary Test and the Wide Range Achievement of Visual Motor Abilities (WRAVMA). The Brazilian 2015 Pelotas Birth Cohort (3818 mother\u2010child pairs) assessed cognition at 2\u00a0years using the INTERGROWTH\u201021st Neurodevelopment Assessment. We used linear regression to estimate associations of acetaminophen use during pregnancy (Project Viva and Pelotas) and infancy (Project Viva) with children's cognitive scores adjusted for maternal age, pre\u2010pregnancy body mass index, education, parity, race\/ethnicity, smoking and alcohol use during pregnancy, depression during pregnancy, antibiotic and ibuprofen use during pregnancy, household income, and child's sex.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In Project Viva, exposure to acetaminophen in both the 1st and 2nd trimester of pregnancy was associated with lower WRAVMA drawing scores (\u03b2 \u22121.51, 95% CI \u22122.92, \u22120.10). However, in Pelotas, exposure to acetaminophen in both the 1st and 2nd trimester of pregnancy was not associated with INTER\u2010NDA motor scores (\u03b2 0.02; 95% CI \u22120.05, 0.09) and was associated with higher INTER\u2010NDA total scores (\u03b2 0.08, 95% CI 0.01, 0.16). Other comparisons did not show evidence for any associations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Inconsistencies and lack of specificity of the findings did not clarify the research question considering that we still have a large variability and uncertainty to define the risk or safety in the use of acetaminophen related to cognition in early childhood. More studies using better exposure assessment and better confounding variables are needed to clarify these associations.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ppe.12632","type":"journal-article","created":{"date-parts":[[2020,1,22]],"date-time":"2020-01-22T10:06:04Z","timestamp":1579687564000},"page":"267-277","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Associations of acetaminophen use during pregnancy and the first year of life with neurodevelopment in early childhood"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4680-3197","authenticated-orcid":false,"given":"Andr\u00e9a D.","family":"Bertoldi","sequence":"first","affiliation":[{"name":"Postgraduate Program in Epidemiology Federal University of Pelotas Pelotas Brazil"},{"name":"Division of Chronic Disease Research Across the Lifecourse Department of Population Medicine Harvard Medical School and Harvard Pilgrim Health Care Institute Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0033-920X","authenticated-orcid":false,"given":"Sheryl L.","family":"Rifas\u2010Shiman","sequence":"additional","affiliation":[{"name":"Division of Chronic Disease Research Across the Lifecourse Department of Population Medicine Harvard Medical School and Harvard Pilgrim Health Care Institute Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7792-4824","authenticated-orcid":false,"given":"Alexandra Crispim","family":"Boing","sequence":"additional","affiliation":[{"name":"Department of Public Health Postgraduate Program in Public Health Federal University of Santa Catarina Florian\u00f3polis Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7566-7745","authenticated-orcid":false,"given":"Tatiane","family":"da Silva Dal Pizzol","sequence":"additional","affiliation":[{"name":"Medicines Production and Control Department Pharmacy College and Post Graduate Program in Epidemiology Federal University of Rio Grande do Sul Porto Alegre Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9156-5036","authenticated-orcid":false,"given":"Vanessa Iribarrem Avena","family":"Miranda","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Epidemiology Federal University of Pelotas Pelotas Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6453-8534","authenticated-orcid":false,"given":"Marysabel Pinto Telis","family":"Silveira","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Epidemiology Federal University of Pelotas Pelotas Brazil"},{"name":"Department of Physiology and Pharmacology Federal University of Pelotas Pelotas 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