{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T00:09:32Z","timestamp":1788307772777,"version":"build-2803163510"},"reference-count":29,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,3,12]],"date-time":"2020-03-12T00:00:00Z","timestamp":1583971200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100010289","name":"Princess Margaret Hospital Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010289","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Paediatric Perinatal Epid"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Post\u2010licensure surveillance studies have shown a small but increased risk of intussusception among infants in the days following rotavirus vaccination (RV).<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>We assessed the temporal trends of intussusception\u2010coded hospitalisations before and after the commencement of a universal rotavirus vaccination programme in Western Australia (WA) in 2007. We also assessed the perinatal factors and pathogens associated with these hospitalisations. <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Intussusception\u2010coded hospitalisations occurring in a cohort of 367\u00a0476 WA\u2010born children (2000\u20102012) aged &lt;5\u00a0years were probabilistically linked to perinatal and pathology records. Age\u2010specific incidence rates for overall and pathogen\u2010specific intussusception\u2010coded hospitalisations were calculated before (2000\u20102006) and after (2008\u20102012) RV introduction. Adjusted Cox proportional hazards models were used to assess perinatal risk factors for intussusception.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The overall rate of intussusception\u2010coded hospitalisation was 26.4 per 100\u00a0000 child\u2010years (95% confidence interval [CI] 24.0, 29.0) among children aged &lt;5\u00a0years, with rates being 70% higher (95% CI 39, 107) in the RV period than in the pre\u2010RV period. Compared with the pre\u2010RV period, rates were higher among those aged 12\u201023\u00a0months (by 55%, 95% CI 5, 127) and 2\u20104\u00a0years (by 84%, 95% CI 20, 182) in the RV period. However, the risk of intussusception\u2010coded hospitalisations associated with intussusception management\u2010related procedure code(s) was similar among all age groups in both birth periods. Among infants aged &lt;12\u00a0months, male sex, non\u2010Aboriginal status, birth to multiparous mothers, and birth in RV era were independent risk factors associated with intussusception\u2010coded hospitalisations. Adenovirus was strongly associated with intussusception (6.7 per 100\u00a0000 child\u2010years, 95% CI 5.3, 9.3).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The risk of intussusception\u2010coded hospitalisations was higher post\u2010RV introduction, but not for intussusception\u2010coded hospitalisations associated with procedure code(s). The increase was no higher in the vaccine\u2010eligible age group than in older age groups, suggesting that the apparent increase is likely to be attributable to causes other than vaccination.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ppe.12669","type":"journal-article","created":{"date-parts":[[2020,3,12]],"date-time":"2020-03-12T12:40:00Z","timestamp":1584016800000},"page":"583-589","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Association between rotavirus vaccination and intussusception in Australian children: A record linkage study"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4516-4127","authenticated-orcid":false,"given":"Parveen","family":"Fathima","sequence":"first","affiliation":[{"name":"Wesfarmers Centre of Vaccines and Infectious Diseases Telethon Kids Institute The University of Western Australia Perth WA Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6434-8290","authenticated-orcid":false,"given":"Hannah C.","family":"Moore","sequence":"additional","affiliation":[{"name":"Wesfarmers Centre of Vaccines and Infectious Diseases Telethon Kids Institute The University of Western Australia Perth WA Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2017-0683","authenticated-orcid":false,"given":"Christopher C.","family":"Blyth","sequence":"additional","affiliation":[{"name":"Wesfarmers Centre of Vaccines and Infectious Diseases Telethon Kids Institute The University of Western Australia Perth WA Australia"},{"name":"School of Medicine The University of Western Australia Perth WA Australia"},{"name":"Department of Infectious Diseases Perth Children's Hospital Perth WA Australia"},{"name":"PathWest Laboratory Medicine WA QEII Medical Centre Perth WA Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4670-0638","authenticated-orcid":false,"given":"Thomas L.","family":"Snelling","sequence":"additional","affiliation":[{"name":"Wesfarmers Centre of Vaccines and Infectious Diseases Telethon Kids Institute The University of Western Australia Perth WA Australia"},{"name":"Department of Infectious Diseases Perth Children's Hospital Perth WA Australia"},{"name":"Menzies School of Health Research and Charles Darwin University Darwin NT Australia"},{"name":"Curtin University Perth WA Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,3,12]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/PEC.0b013e31818c2a3e"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0068482"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0036-1593429"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2006.04.010"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2011.05.008"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2014.10.018"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)60222-6"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.107.6.e97"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa052434"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa052664"},{"issue":"3","key":"e_1_2_9_12_1","first-page":"E208","article-title":"Immunisation 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Steering Committee on Diarrhoeal Disease Vaccines Vaccine Development Vaccines and Biologicals World Health Organization Geneva Switzerland. 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