{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T15:18:15Z","timestamp":1779895095654,"version":"3.53.1"},"reference-count":16,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,6,2]],"date-time":"2020-06-02T00:00:00Z","timestamp":1591056000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"USAID\/CDC\/Vysnova Partners","award":["NU2GGH001732"],"award-info":[{"award-number":["NU2GGH001732"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Paediatric Perinatal Epid"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Zika virus (ZIKV) infection during pregnancy can cause infant brain and eye abnormalities and has been associated with adverse neurodevelopmental outcomes in exposed infants. Evidence is limited on ZIKV\u2019s effects on children infected postnatally within the first year of life.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine whether any adverse neurodevelopmental outcomes occurred in early childhood for children infected postnatally with ZIKV during infancy, given the neurotoxicity of ZIKV infection and the rapid brain development that occurs in infancy and early childhood.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The Colombia Instituto Nacional de Salud (INS) conducted health and developmental screenings between September and November 2017 to evaluate 60 children at ages 20\u201030\u00a0months who had laboratory\u2010confirmed symptomatic postnatal ZIKV infection at ages 1\u201012\u00a0months. We examined the frequency of adverse neurologic, hearing, eye, and developmental outcomes as well as the relationship between age at Zika symptom onset and developmental outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Nine of the 60 (15.0%) children had adverse outcomes on the neurologic, hearing, or eye examination. Six of the 47 (12.8%) children without these adverse findings, and who received a valid developmental screening, had an alert score in the hearing\u2010language domain which signals the need for additional developmental evaluation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Neurologic, hearing, eye, and developmental findings suggest reassuring results. Since the full spectrum of neurodevelopmental outcomes in children postnatally infected with ZIKV remains unknown, routine paediatric care is advised to monitor the development of these children to ensure early identification of any adverse neurodevelopmental outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ppe.12690","type":"journal-article","created":{"date-parts":[[2020,6,3]],"date-time":"2020-06-03T03:19:28Z","timestamp":1591154368000},"page":"92-97","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Neurodevelopmental findings in children 20\u201030\u00a0months of age with postnatal Zika infection at 1\u201012\u00a0months of age, Colombia, September\u2010November 2017"],"prefix":"10.1111","volume":"35","author":[{"given":"Oscar","family":"Pacheco","sequence":"first","affiliation":[{"name":"Instituto Nacional de Salud Bogot\u00e1 Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1156-3066","authenticated-orcid":false,"given":"Suzanne M.","family":"Newton","sequence":"additional","affiliation":[{"name":"Division of Birth Defects and Infant Disorders National Center on Birth Defects and Developmental Disabilities, CDC Atlanta GA USA"},{"name":"Eagle Global Scientific Atlanta GA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcela","family":"Daza","sequence":"additional","affiliation":[{"name":"Vysnova Partners, Inc Atlanta GA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordan E.","family":"Cates","sequence":"additional","affiliation":[{"name":"Division of Birth Defects and Infant Disorders National Center on Birth Defects and Developmental Disabilities, CDC Atlanta GA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier Alberto Madero","family":"Reales","sequence":"additional","affiliation":[{"name":"Field Epidemiology Training Program Instituto Nacional de Salud Bogot\u00e1 Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronica K.","family":"Burkel","sequence":"additional","affiliation":[{"name":"Division of Birth Defects and Infant Disorders National Center on Birth Defects and Developmental Disabilities, CDC Atlanta GA USA"},{"name":"Eagle Medical Services, LLC Atlanta GA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcela","family":"Mercado","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Salud Bogot\u00e1 Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shana","family":"Godfred\u2010Cato","sequence":"additional","affiliation":[{"name":"Division of Birth Defects and Infant Disorders National Center on Birth Defects and Developmental Disabilities, CDC Atlanta GA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maritza","family":"Gonzalez","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Salud Bogot\u00e1 Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7612-9500","authenticated-orcid":false,"given":"Kayla N.","family":"Anderson","sequence":"additional","affiliation":[{"name":"Division of Birth Defects and Infant Disorders National Center on Birth Defects and Developmental Disabilities, CDC Atlanta GA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kate R.","family":"Woodworth","sequence":"additional","affiliation":[{"name":"Division of Birth Defects and Infant Disorders National Center on Birth Defects and Developmental Disabilities, CDC Atlanta GA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Valencia","sequence":"additional","affiliation":[{"name":"Division of Birth Defects and Infant 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