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The existing literature has examined NVP from the perspective of the mother, and relatively less is known about offspring outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To study the relationships of\u00a0NVP with social\u2010emotional, behavioural, and cognitive outcomes of the offspring in a multi\u2010ethnic Asian cohort.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In the Growing Up in Singapore Towards Healthy Outcomes prospective mother\u2010offspring cohort study, mothers responded to a structured NVP questionnaire at 26\u201028\u00a0weeks\u2019 gestation (n\u00a0=\u00a01172) and participants with severe NVP were confirmed using medical records. Children underwent multiple neurodevelopmental assessments throughout childhood. We conducted multivariable regressions with post\u2010estimation predictive margins to understand the associations of NVP with offspring neurobehavioural outcomes, which included 1\u2010year Infant\u2010Toddler Social and Emotional Assessment, 1.5\u2010year Quantitative Checklist for Autism in Toddlers, 2\u2010year Bayley Scales of Infant and Toddler Development, 2\u2010 and 4\u2010year Child Behavior Checklist, and 4.5\u2010year Kaufman Brief Intelligence Test. Analyses were adjusted for household income, birth variables, maternal mental health, and other relevant medical variables. Cohen's <jats:italic>d<\/jats:italic> effect sizes were calculated using standardised mean differences (\u03bc<jats:sub>d<\/jats:sub>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mothers were categorised into no (n\u00a0=\u00a0296, 25.3%), mild\u2010moderate (n\u00a0=\u00a0686, 58.5%), and severe NVP (n\u00a0=\u00a0190, 16.2%), of whom 67 (5.7%) required admission. Compared to children of mothers who had no or mild\u2010moderate NVP, children with exposure to severe NVP exhibited more externalising behaviours (\u03bc<jats:sub>d<\/jats:sub> 2.0, 95% CI 0.3, 3.6; Cohen's <jats:italic>d<\/jats:italic>\u00a0=\u00a00.33) and social communication difficulties before 2\u00a0years (\u03bc<jats:sub>d<\/jats:sub> 4.1, 95% Cl 0.1, 8.0; Cohen's <jats:italic>d<\/jats:italic>\u00a0=\u00a00.38), both externalising (\u03bc<jats:sub>d<\/jats:sub> 1.5, 95% CI 0.4, 2.6; Cohen's <jats:italic>d<\/jats:italic>\u00a0=\u00a00.43) and internalising behaviours at 2\u00a0years (\u03bc<jats:sub>d<\/jats:sub> 1.2, 95% CI 0.1, 2.2; Cohen's <jats:italic>d<\/jats:italic>\u00a0=\u00a00.35), and only internalising behaviours after 2\u00a0years (\u03bc<jats:sub>d<\/jats:sub> 1.1, 95% CI 0.4, 2.0; Cohen's <jats:italic>d<\/jats:italic>\u00a0=\u00a00.37).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Severe NVP is highly prevalent in this Asian cohort and may be adversely associated with multiple offspring neurobehavioural outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ppe.12703","type":"journal-article","created":{"date-parts":[[2020,6,24]],"date-time":"2020-06-24T03:10:22Z","timestamp":1592968222000},"page":"98-108","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Severity of nausea and vomiting in pregnancy and early childhood neurobehavioural outcomes: The Growing Up in Singapore Towards Healthy Outcomes study"],"prefix":"10.1111","volume":"35","author":[{"given":"Nicholas L.","family":"Syn","sequence":"first","affiliation":[{"name":"Yong Loo Lin School of Medicine National University of Singapore Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiao\u2010Yng","family":"Chan","sequence":"additional","affiliation":[{"name":"Yong Loo Lin School of Medicine National University of Singapore Singapore Singapore"},{"name":"Department of Obstetrics and Gynaecology National University Health System Singapore Singapore"},{"name":"Agency for Science, Technology and Research (A*STAR) Singapore Institute for Clinical Sciences (SICS) Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisha Wan Ying","family":"Chia","sequence":"additional","affiliation":[{"name":"Yong Loo Lin School of Medicine National University of Singapore Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei Xin","family":"Ong","sequence":"additional","affiliation":[{"name":"Yong Loo Lin School of Medicine National University of Singapore Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Desiree","family":"Phua","sequence":"additional","affiliation":[{"name":"Agency for Science, Technology and Research (A*STAR) Singapore Institute for Clinical Sciences (SICS) Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shirong","family":"Cai","sequence":"additional","affiliation":[{"name":"Agency for Science, Technology and Research (A*STAR) Singapore Institute for Clinical Sciences (SICS) Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynette P. 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