{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T10:24:10Z","timestamp":1779877450689,"version":"3.53.1"},"reference-count":54,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,8,16]],"date-time":"2021-08-16T00:00:00Z","timestamp":1629072000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["FDN\u2010148438"],"award-info":[{"award-number":["FDN\u2010148438"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Paediatric Perinatal Epid"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Studies suggest maternal weight and weight gain during pregnancy may influence foetal immunological development. However, their role in the aetiology of allergic disease is unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>We sought to examine the impact of maternal pre\u2010pregnancy body mass index (BMI) and gestational weight gain (GWG) on the incidence of four common paediatric allergic diseases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a retrospective, population\u2010based cohort study of all singleton live births in Ontario, Canada between 2012 and 2014, using maternal\u2010newborn records from the provincial birth registry linked with health administrative databases. Neonates were followed up to 7\u00a0years for anaphylaxis, asthma, dermatitis and rhinitis, identified through validated algorithms based on healthcare encounters. We multiply imputed missing data and employed Cox proportional\u2010hazards models to calculate adjusted hazard ratios (aHR) with 95% confidence intervals (CI). To test the robustness of our findings, we also conducted several sensitivity analyses, including probabilistic bias analyses for exposure and outcome misclassification. All methods were prespecified in a published protocol.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 248,017 infants followed, 52% were born to mothers with a pre\u2010pregnancy BMI in the normal range and only 19% were born to mothers with adequate weight gain during pregnancy. Incidence rates (per 100,000 person\u2010days) for anaphylaxis, asthma, dermatitis and rhinitis were 0.22, 6.80, 12.41 and 1.54, respectively. Compared with normal BMI, maternal obesity was associated with increased hazards of asthma in offspring (aHR 1.08, 95% CI 1.05, 1.11), but decreased hazards of anaphylaxis (aHR 0.83, 95% CI 0.69, 0.99) and dermatitis (aHR 0.97, 95% CI 0.94, 0.99). In contrast, maternal underweight was associated with increased hazards of dermatitis (aHR 1.06, 95% CI 1.02, 1.10). We found no associations between pre\u2010pregnancy BMI and rhinitis or GWG and any allergic outcome, and no evidence of effect measures modification by infant sex.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These findings provide support for the involvement of maternal pre\u2010pregnancy BMI in paediatric allergic disease development.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ppe.12806","type":"journal-article","created":{"date-parts":[[2021,8,16]],"date-time":"2021-08-16T08:06:00Z","timestamp":1629101160000},"page":"144-155","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Examining the role of pre\u2010pregnancy weight and gestational weight gain in allergic disease development among offspring: A population\u2010based cohort study in Ontario, Canada"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9117-103X","authenticated-orcid":false,"given":"Sebastian A.","family":"Srugo","sequence":"first","affiliation":[{"name":"School of Epidemiology and Public Health University of Ottawa  Ottawa ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deshayne B.","family":"Fell","sequence":"additional","affiliation":[{"name":"School of Epidemiology and Public Health University of Ottawa  Ottawa ON Canada"},{"name":"Children\u2019s Hospital of Eastern Ontario Research Institute  Ottawa ON Canada"},{"name":"ICES  Ottawa ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7063-3354","authenticated-orcid":false,"given":"Daniel J.","family":"Corsi","sequence":"additional","affiliation":[{"name":"School of Epidemiology and Public Health University of Ottawa  Ottawa ON Canada"},{"name":"Children\u2019s Hospital of Eastern Ontario 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Ontario  Ottawa ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7527-5354","authenticated-orcid":false,"given":"Laura M.","family":"Gaudet","sequence":"additional","affiliation":[{"name":"School of Epidemiology and Public Health University of Ottawa  Ottawa ON Canada"},{"name":"OMNI Research Group Ottawa Hospital Research Institute University of Ottawa  Ottawa ON Canada"},{"name":"Department of Obstetrics and Gynaecology Queen\u2019s University  Kingston ON Canada"},{"name":"Department of Obstetrics and Gynaecology Kingston Health Sciences Centre  Kingston ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,8,16]]},"reference":[{"key":"e_1_2_9_2_1","volume-title":"WAO White Book on Allergy 2013 Update","author":"Pawankar R","year":"2013"},{"key":"e_1_2_9_3_1","volume-title":"Health Fact Sheets: Chronic Conditions, 2017","author":"Statistics 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