{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T11:20:33Z","timestamp":1791890433439,"version":"4.3.4"},"reference-count":61,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,12,10]],"date-time":"2021-12-10T00:00:00Z","timestamp":1639094400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","award":["R01\u2010ES028923"],"award-info":[{"award-number":["R01\u2010ES028923"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Paediatric Perinatal Epid"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Animal and epidemiologic studies indicate that air pollution may adversely affect fertility. Epidemiologic studies have been restricted largely to couples undergoing fertility treatment or have retrospectively ascertained time\u2010to\u2010pregnancy among pregnant women.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>We examined the association between residential ambient air pollution and fecundability, the per\u2010cycle probability of conception, in a large preconception cohort of Danish pregnancy planners.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>During 2007\u20132018, we used the Internet to recruit and follow women who were trying to conceive without the use of fertility treatment. Participants completed an online baseline questionnaire eliciting socio\u2010demographic characteristics, lifestyle factors, and medical and reproductive histories and follow\u2010up questionnaires every 8\u00a0weeks to ascertain pregnancy status. We determined concentrations of ambient nitrogen oxides (NO<jats:sub>x<\/jats:sub>), nitrogen dioxide (NO<jats:sub>2<\/jats:sub>), carbon monoxide (CO), ozone (O<jats:sub>3<\/jats:sub>), particulate matter &lt;2.5\u00a0\u00b5m (PM<jats:sub>2.5<\/jats:sub>) and &lt;10\u00a0\u00b5m (PM<jats:sub>10<\/jats:sub>), and sulphur dioxide (SO<jats:sub>2<\/jats:sub>) at each participant's residential address. We calculated average exposure during the year before baseline, during each menstrual cycle over follow\u2010up and during the entire pregnancy attempt time. We used proportional probabilities regression models to estimate fecundability ratios (FRs) and 95% confidence intervals (CIs), adjusting for potential confounders and co\u2010pollutants. The analysis was restricted to the 10,183 participants who were trying to conceive for &lt;12 cycles at study entry whose addresses could be geocoded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>During 12\u00a0months of follow\u2010up, 73% of participants conceived. Higher concentrations of PM<jats:sub>2.5<\/jats:sub> and PM<jats:sub>10<\/jats:sub> were associated with small reductions in fecundability. For example, the FRs for a one interquartile range (IQR) increase in PM<jats:sub>2.5<\/jats:sub> (IQR\u00a0=\u00a03.2\u00a0\u00b5g\/m<jats:sup>3<\/jats:sup>) and PM<jats:sub>10<\/jats:sub> (IQR\u00a0=\u00a05.3\u00a0\u00b5g\/m<jats:sup>3<\/jats:sup>) during each menstrual cycle were 0.93 (95% CI: 0.87, 0.99) and 0.91 (95% CI: 0.84, 0.99), respectively. Other air pollutants were not appreciably associated with fecundability.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In this preconception cohort study of Danish women, residential exposures to PM<jats:sub>2.5<\/jats:sub> and PM<jats:sub>10<\/jats:sub> were associated with reduced fecundability.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ppe.12832","type":"journal-article","created":{"date-parts":[[2021,12,10]],"date-time":"2021-12-10T14:20:52Z","timestamp":1639146052000},"page":"57-67","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Air pollution and fecundability: Results from a Danish preconception cohort study"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3929-4451","authenticated-orcid":false,"given":"Amelia K.","family":"Wesselink","sequence":"first","affiliation":[{"name":"Department of Epidemiology Boston University School of Public Health 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